WNT4

WNT4 (Wnt family member 4), also called Wingless-type MMTV integration site family member 4, is a secreted glycoprotein. It regulates canonical (β-catenin-dependent) and non-canonical Wnt signaling pathways, supporting embryonic development (e.g., female reproductive tract and kidney formation) and adult tissue homeostasis like stem cell maintenance.
Mutations in WNT4 cause Mayer-Rokitansky-Küster-Hauser syndrome and polycystic kidney disease, and its dysregulation links to ovarian and breast cancers. Direct WNT4-targeted drugs are early-stage, but Wnt pathway inhibitors (e.g., Porcupine inhibitors) are in clinical trials for disorders with aberrant WNT4 signaling.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

WNT4 Antibody (CSB-PA026137LA01HU)

Validated Data

Western blot
All lanes: WNT4 antibody at 8μg/ml + MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 40, 33 kDa
Observed band size: 40 kDa

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA026137LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA026137LA01HU at dilution of 1:100

IHC image of CSB-PA026137LA01HU diluted at 1:300 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Protein Wnt-4(WNT4) ELISA kit (CSB-EL026137HU)

Validated Data

Code: CSB-EL026137HU

Size: 96T,5×96T,10×96T

Sensitivity: 5.8 pg/mL

Detection Range: 23.5 pg/mL-1500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following WNT4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

WNT4 Antibodies

WNT4 Proteins

WNT4 ELISA Kits

WNT4 Antibodies

WNT4 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA026137GA01HU	WNT4 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA026137LA01HU	WNT4 Antibody	Human	ELISA, WB, IHC
CSB-PA026137LC01HU	WNT4 Antibody, FITC conjugated	Human
CSB-PA026137LD01HU	WNT4 Antibody, Biotin conjugated	Human	ELISA
CSB-PA026137LB01HU	WNT4 Antibody, HRP conjugated	Human	ELISA

WNT4 Antibodies for Drosophila melanogaster (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA026137XA01DLU	Wnt4 Antibody	Drosophila melanogaster (Fruit fly)	ELISA, WB (ensure identification of antigen)

WNT4 Proteins

WNT4 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP026137MO CSB-EP026137MO CSB-EP026137MO-B	Recombinant Mouse Protein Wnt-4 (Wnt4)	Yeast E.coli In Vivo Biotinylation in E.coli
CSB-BP026137MO	Recombinant Mouse Protein Wnt-4 (Wnt4)	Baculovirus
CSB-MP026137MO	Recombinant Mouse Protein Wnt-4 (Wnt4)	Mammalian cell
CSB-EP026137MOa0	Recombinant Mouse Protein Wnt-4 (Wnt4)	E.coli

WNT4 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP026137CH CSB-EP026137CH CSB-BP026137CH CSB-MP026137CH CSB-EP026137CH-B	Recombinant Chicken Protein Wnt-4 (WNT4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

WNT4 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP026137HU CSB-BP026137HU CSB-EP026137HU-B	Recombinant Human Protein Wnt-4 (WNT4)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP026137HU	Recombinant Human Protein Wnt-4 (WNT4)	E.coli
CSB-MP026137HU	Recombinant Human Protein Wnt-4 (WNT4)	Mammalian cell
CSB-EP026137HUc7	Recombinant Human Protein Wnt-4 (WNT4)	E.coli

WNT4 Proteins for Anser caerulescens (Snow goose) (Chen caerulescens)

Code	Product Name	Source
CSB-YP026137AKY CSB-EP026137AKY CSB-BP026137AKY CSB-MP026137AKY CSB-EP026137AKY-B	Recombinant Anser caerulescens Protein Wnt-4 (WNT4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

WNT4 Proteins for Drosophila melanogaster (Fruit fly)

Code	Product Name	Source
CSB-YP026137DLU CSB-EP026137DLU CSB-BP026137DLU CSB-MP026137DLU CSB-EP026137DLU-B	Recombinant Drosophila melanogaster Protein Wnt-4 (Wnt4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

WNT4 Proteins for Meleagris gallopavo (Wild turkey)

Code	Product Name	Source
CSB-YP026137MQV CSB-EP026137MQV CSB-BP026137MQV CSB-MP026137MQV CSB-EP026137MQV-B	Recombinant Meleagris gallopavo Protein Wnt-4 (WNT4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

WNT4 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP026137XBE CSB-EP026137XBE CSB-BP026137XBE CSB-MP026137XBE CSB-EP026137XBE-B	Recombinant Xenopus laevis Protein Wnt-4 (wnt4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

WNT4 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP889557RA CSB-EP889557RA CSB-BP889557RA CSB-MP889557RA CSB-EP889557RA-B	Recombinant Rat Protein Wnt-4 (Wnt4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

WNT4 ELISA Kit

WNT4 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL026137HU	Human Protein Wnt-4(WNT4) ELISA kit	serum, plasma, tissue homogenates	5.8 pg/mL

WNT4 ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-EL026137MO	Mouse Protein Wnt-4(WNT4) ELISA kit	serum, plasma, tissue homogenates	1.95 pg/mL

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