Human Angiopoietin 4,ANG-4 ELISA Kit

Code CSB-E11182h
Size 96T,5×96T,10×96T
Price Request a Quote or Start an on-line Chat
Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details

Target Name
angiopoietin 4
Alternative Names
AGP4 ELISA Kit; ANG-3 ELISA Kit; ANG-4 ELISA Kit; ANG3 ELISA Kit; ANG4 ELISA Kit; Angiopoietin 3 ELISA Kit; Angiopoietin 4 ELISA Kit; Angiopoietin-3 ELISA Kit; Angiopoietin-4 ELISA Kit; ANGP4_HUMAN ELISA Kit; ANGPT4 ELISA Kit; dJ824F16.2 (angiopoietin 4) ELISA Kit; MGC138181 ELISA Kit; MGC138183 ELISA Kit; OTTHUMP00000029947 ELISA Kit
Abbreviation
ANGPT4
Uniprot No.
Species
Homo sapiens (Human)
Detection Range
Request Information
Sensitivity
Request Information
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Cardiovascular
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

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Target Background

Function
(From Uniprot)
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
Gene References into Functions
  1. Ang-4 also promoted survival of LECs. Thus, blocking Ang-4 may prune the draining lymphatic vasculature and decrease interstitial fluid pressure (IFP) by reducing vascular permeability. PMID: 25977256
  2. acute-phase protein A1AT is a physiological regulator of angptl4, another acute-phase protein. PMID: 24760148
  3. Angptl4 is a glucocorticoid-responsive mediator of fasting-induced intracellular lipolysis and stimulates cAMP signaling in adipocytes PMID: 22267746
  4. In tumor cells, only Ang-4 expression has prognostic impact in NSCLC. In NSCLC tumor stroma, Ang-4 and Ang-2 are independently associated with survival. PMID: 21603628
  5. Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer disease and vascular dementia is reported. PMID: 20596041
  6. Results establish the novel effects of Ang-4 on tumor angiogenesis and GBM progression and suggest that this pro-GBM effect of Ang-4 is mediated by promoting tumor angiogenesis and activating Erk1/2 kinase in GBM cells. PMID: 20823154
  7. the angiopoietin/Tie-2 system may participate in the angiogenic response to hypoxia in renal tissues and in tumor angiogenesis in renal carcinoma. PMID: 15198927
  8. Recombinant Ang4 formed disulfide-linked dimers. Ang4 produces corneal angiogenesis extending from the limbus across the mouse cornea in vivo. Ang4 is an agonist of Tie2. PMID: 15284220
  9. angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure PMID: 16790085
  10. Results describe the expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumors, leiomyomas and schwannomas. PMID: 17724803

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Subcellular Location
Secreted.
Tissue Specificity
Highly expressed in the lung with much lower levels found in other tissues.
Database Links

HGNC: 487

OMIM: 603705

KEGG: hsa:51378

STRING: 9606.ENSP00000371347

UniGene: Hs.278973

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