ANGPT4 Antibody

Code CSB-PA584378
Size US$166
Order now
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA584378(ANGPT4 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA584378(ANGPT4 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human right lung tissue, Human left lung cancer tissue, Primary antibody: CSB-PA584378(ANGPT4 Antibody) at dilution 1/480, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Target Names
Alternative Names
AGP4 antibody; ANG-3 antibody; ANG-4 antibody; ANG3 antibody; ANG4 antibody; Angiopoietin 3 antibody; Angiopoietin 4 antibody; Angiopoietin-3 antibody; Angiopoietin-4 antibody; ANGP4_HUMAN antibody; ANGPT4 antibody; dJ824F16.2 (angiopoietin 4) antibody; MGC138181 antibody; MGC138183 antibody; OTTHUMP00000029947 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of Human ANGPT4
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:10000
WB 1:200-1:1000
IHC 1:100-1:300
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
Gene References into Functions
  1. Ang-4 also promoted survival of LECs. Thus, blocking Ang-4 may prune the draining lymphatic vasculature and decrease interstitial fluid pressure (IFP) by reducing vascular permeability. PMID: 25977256
  2. acute-phase protein A1AT is a physiological regulator of angptl4, another acute-phase protein. PMID: 24760148
  3. Angptl4 is a glucocorticoid-responsive mediator of fasting-induced intracellular lipolysis and stimulates cAMP signaling in adipocytes PMID: 22267746
  4. In tumor cells, only Ang-4 expression has prognostic impact in NSCLC. In NSCLC tumor stroma, Ang-4 and Ang-2 are independently associated with survival. PMID: 21603628
  5. Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer disease and vascular dementia is reported. PMID: 20596041
  6. Results establish the novel effects of Ang-4 on tumor angiogenesis and GBM progression and suggest that this pro-GBM effect of Ang-4 is mediated by promoting tumor angiogenesis and activating Erk1/2 kinase in GBM cells. PMID: 20823154
  7. the angiopoietin/Tie-2 system may participate in the angiogenic response to hypoxia in renal tissues and in tumor angiogenesis in renal carcinoma. PMID: 15198927
  8. Recombinant Ang4 formed disulfide-linked dimers. Ang4 produces corneal angiogenesis extending from the limbus across the mouse cornea in vivo. Ang4 is an agonist of Tie2. PMID: 15284220
  9. angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure PMID: 16790085
  10. Results describe the expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumors, leiomyomas and schwannomas. PMID: 17724803

Show More

Hide All

Subcellular Location
Secreted.
Tissue Specificity
Highly expressed in the lung with much lower levels found in other tissues.
Database Links

HGNC: 487

OMIM: 603705

KEGG: hsa:51378

STRING: 9606.ENSP00000371347

UniGene: Hs.278973

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*