Human Pregnancy Specific β1 Glycoprotein (SP1/PSβ1-G) ELISA kit

Code CSB-E09133h
Size 96T,5×96T,10×96T
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Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
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Product Details

Target Name
Pregnancy Specific β1 Glycoprotein (SP1/PSβ1-G)
Alternative Names
B1G1 ELISA Kit; Carcinoembryonic antigen SG8 ELISA Kit; CD66 antigen-like family member F ELISA Kit; CD66f ELISA Kit; CD66f antigen ELISA Kit; CEA ELISA Kit; DHFRP2 ELISA Kit; Fetal liver non-specific cross-reactive antigen 1/2 ELISA Kit; FL-NCA-1/2 ELISA Kit; PBG 1 ELISA Kit; PBG1 ELISA Kit; Pregnancy specific B 1 glycoprotein ELISA Kit; Pregnancy specific beta 1 glycoprotein 1 ELISA Kit; Pregnancy specific beta 1 glycoprotein 2 ELISA Kit; Pregnancy specific beta 1 glycoprotein 7 ELISA Kit; Pregnancy specific beta 1 glycoprotein 8 ELISA Kit; Pregnancy specific beta 1 glycoprotein ELISA Kit; Pregnancy specific beta 1 glycoprotein C/D ELISA Kit; Pregnancy-specific beta-1 glycoprotein C/D ELISA Kit; Pregnancy-specific beta-1-glycoprotein 1 ELISA Kit; Pregnancy-specific glycoprotein 1 ELISA Kit; PS beta C/D ELISA Kit; PS-beta-C/D ELISA Kit; PS-beta-G-1 ELISA Kit; PSBG 1 ELISA Kit; PSBG 2 ELISA Kit; PSBG-1 ELISA Kit; PSBG1 ELISA Kit; PSBG2 ELISA Kit; PSG 1 ELISA Kit; PSG 2 ELISA Kit; PSG 8 ELISA Kit; PSG 95 ELISA Kit; PSG IIA d ELISA Kit; PSG1 ELISA Kit; PSG1_HUMAN ELISA Kit; PSG2 ELISA Kit; PSG8 ELISA Kit; PSG95 ELISA Kit; PSGGA ELISA Kit; PSGGB ELISA Kit; PSGIIA a ELISA Kit; PSGIIA ELISA Kit; PSGIIA b ELISA Kit; PSGIIA c ELISA Kit; SP 1 ELISA Kit; SP1 ELISA Kit
Abbreviation
SP1/PSβ1-G
Uniprot No.
Species
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
1.0 μg/mL-400 μg/mL
Sensitivity
1.0 μg/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Tags & Cell Markers
Assay Principle
quantitative
Measurement
Competitive
Precision
Intra-assay Precision (Precision within an assay): CV%<15%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<15%
Three samples of known concentration were tested in twenty assays to assess.
Linearity
To assess the linearity of the assay, samples were spiked with high concentrations of human SP1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
SampleSerum(n=4)
1:1Average %96
Range %89-106
1:2Average %90
Range %89-104
1:4Average %95
Range %88-100
1:8Average %87
Range %82-99
Recovery
The recovery of human SP1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample TypeAverage % RecoveryRange
Serum (n=5) 9586-107
EDTA plasma (n=4)9791-100
Typical Data
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
μg/mlOD1OD2Average
4000.139 0.144 0.142
750.269 0.278 0.274
12.50.534 0.556 0.545
3.50.853 0.873 0.863
11.452 1.464 1.458
02.137 2.161 2.149
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx
Description

This Human SP1/PSβ1-G ELISA Kit was designed for the quantitative measurement of Human SP1/PSβ1-G protein in serum, plasma, tissue homogenates. It is a Competitive ELISA kit, its detection range is 1.0 μg/mL-400 μg/mL and the sensitivity is 1.0 μg/mL.

Citations

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Target Background

Gene References into Functions
  1. Inhibiting PSG1 can effectively reduce chemoresistance via a transforming growth factor-beta (TGF-beta)-related pathway in ER-negative breast cancer cells. PMID: 27653744
  2. PSG stimulated IDO activity under the conditions of induction of the monocytes by interferon-gamma. PMID: 27595833
  3. Under conditions of directed induction of phenotypic changes in CD4(+) lymphocytes to regulatory T cells (Treg), pregnancy-specific at high concentrations (10 and 100 mug/mL) increased FOXP3 expression. The evaluation of the spontaneous expression level of FOXP3 mRNA showed that pregnancy-specific beta1-glycoprotein (1 and 100 mug/mL) stimulated the expression of this factor in mononuclear cells and isolated CD4(+) lym... PMID: 27817017
  4. results identify a non-placental site of PSG expression in the gut and associated tumors, with implications for determining whether PSGs have a role in tumor progression, and utility as tumor biomarkers. PMID: 26926266
  5. the presence of GAGs on the surface of endothelial cells was required for the ability of PSG1 to induce tube formation PMID: 21193412
  6. The aspartic acid at position 95 is not required for PSG1 activity but the amino acids implicated in the formation of a salt bridge within the N-domain are essential. PMID: 20335639
  7. first trimester maternal serum marker of small-for-gestational age and preterm delivery PMID: 19911417
  8. Human PSG1a induces alternative activation in human & mouse monocytes & suppresses the accessory-cell-dependent T-cell proliferation. PSG1a contributes to immunomodulation during pregnancy, with opposite effects on maternal innate & adaptative systems. PMID: 12223519
  9. The differential expression of HLA-E and PSG1 in the sperm of fertile and infertile men is discussed. PMID: 18987160

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Subcellular Location
Secreted.
Protein Families
Immunoglobulin superfamily, CEA family
Database Links

HGNC: 9514

OMIM: 176390

KEGG: hsa:5669

STRING: 9606.ENSP00000244296

UniGene: Hs.709192

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