Human myelin-associated glycoprotein(MAG) ELISA Kit

Code CSB-E17901h
Size 96T,5×96T,10×96T
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Product Details

Target Name
myelin associated glycoprotein
Alternative Names
GMA ELISA Kit; MAG ELISA Kit; MAG_HUMAN ELISA Kit; Myelin associated glycoprotein ELISA Kit; Myelin-associated glycoprotein ELISA Kit; S MAG ELISA Kit; S-MAG ELISA Kit; Sialic acid binding Ig like lectin 4A ELISA Kit; Sialic acid binding immunoglobulin like lectin 4A ELISA Kit; Siglec 4a ELISA Kit; Siglec-4a ELISA Kit; SIGLEC4A ELISA Kit; SPG75 ELISA Kit
Uniprot No.
Homo sapiens (Human)
Sample Types
serum, plasma, cerebrospinal fluid (CSF)
Detection Range
0.625 ng/mL-40 ng/mL
0.156 ng/mL
Assay Time
Sample Volume
Detection Wavelength
450 nm
Research Area
Assay Principle
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
To assess the linearity of the assay, samples were spiked with high concentrations of human MAG in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
1:1Average %98
Range %89-101
1:2Average %92
Range %84-96
1:4Average %90
Range %85-95
1:8Average %98
Range %90-102
The recovery of human MAG spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample TypeAverage % RecoveryRange
Serum (n=5) 9789-101
EDTA plasma (n=4)9890-102
Typical Data
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
401.754 1.721 1.738 1.615
201.395 1.422 1.409 1.286
100.872 0.911 0.892 0.769
50.551 0.555 0.553 0.430
2.50.365 0.348 0.357 0.234
1.250.231 0.242 0.237 0.114
0.6250.187 0.184 0.186 0.063
00.124 0.122 0.123
and FAQs
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

This Human MAG ELISA Kit was designed for the quantitative measurement of Human MAG protein in serum, plasma, cerebrospinal fluid (CSF). It is a Sandwich ELISA kit, its detection range is 0.625 ng/mL-40 ng/mL and the sensitivity is 0.156 ng/mL.

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Target Background

(From Uniprot)
Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth. Inhibits axon outgrowth by binding to RTN4R. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b.
Gene References into Functions
  1. we observed two-way correlations between the MOG and MAG levels and the fractional anisotropy and mean diffusivity values in the white matter of the left middle frontal lobe, right inferior parietal lobe, and right supplementary motor area in major depressive disorder patients PMID: 29477585
  2. polyneuropathy associated with anti-MAG antibodies is less homogeneous. PMID: 26065001
  3. This study identify involvement of myelin-associated glycoprotein in this family with a disorder affecting the central and peripheral nervous system, and suggest that loss of the protein function is responsible for the unique clinical phenotype PMID: 26179919
  4. Results show that MAG is important for axon-glia contact in a model for Charcot-Marie-Tooth disease type 1A, and suggest that its increased expression in patients has a compensatory role in the disease pathology PMID: 22940629
  5. Increased serum levels of MAG (and MBP) were found in autistic patients with allergic manifestations compared to those without these manifestations. PMID: 23726766
  6. Primary mitochondrial respiratory chain defects affecting the white matter, and unrelated to inflammation, are associated with MAG loss and central nervous system demyelination. PMID: 22491194
  7. Distal acquired demyelinating symmetric neuropathy without anti-MAG antibodies is more likely to be considered a variant of chronic inflammatory demyelinating polyradiculoneuropathy, including a hematological or immunological condition. PMID: 21199182
  8. polysialylated NCAM persistence, up-regulated polysialyltransferase-1 mRNA and previously uncovered defective myelin-associated glycoprotein may be early pathogenetic events in adult-onset autosomal-dominant leukodystrophy PMID: 19725832
  9. Myelin destruction with preferential loss of MAG is found in autopsy brains with acute white matter ischemia as well as in HSV- and CMV-encephalitis. PMID: 12528815
  10. Possible association of MAG and schizophrenia in a Chinese Han cohort of family trios PMID: 15820319
  11. Our findings of a significant associations between schizophrenia and the MAG gene suggest that this gene may be involved in susceptibility to schizophrenia in the Chinese Han population. PMID: 16039057
  12. Expression of MAG, CNP and OLIG2 did not differ between patients with schizophrenia and controls in the grey or white matter PMID: 17964117
  13. These results support the hypothesis that the adhesive interactions between MUC1 and MAG are of biological significance in pancreatic cancer perineural invasion. PMID: 17974963
  14. Twenty of 46 patients with IgM amyloidosis (7 with and 13 without polyneuropathy) had elevation of anti-MAG or SGPG by enzyme-linked immunosorbent assay PMID: 18236455
  15. This finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population. PMID: 18496213
  16. In our patient, propriospinal myoclonus was associated with anti-MAG polyneuropathy, but the causal relationship remains unclear. PMID: 18816614
  17. RNF10 is a trans-acting protein regulating MAG expression and is required for myelin formation. PMID: 18941509
  18. Taken together, these findings suggest that in anti-MAG neuropathy patients, IgM deposits are entrapped within cutaneous perineurium-ensheathed nerve bundles where they accumulate in the endoneurial space. PMID: 19151627
  19. ELISA is more sensitive than Western blot to diagnose anti-myelin-associated glycoprotein related polyneuropathy, although a positive serology may be found in other forms of polyneuropathy as well. PMID: 19720975

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Involvement in disease
Spastic paraplegia 75, autosomal recessive (SPG75)
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Membrane raft.
Protein Families
Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
Tissue Specificity
Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures. Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths. Detecte
Database Links

HGNC: 6783

OMIM: 159460

KEGG: hsa:4099

STRING: 9606.ENSP00000376048

UniGene: Hs.643440

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