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| Product Type | Recombinant Protein |
| Uniprot No. | P20916 |
| Species | Homo sapiens (Human) |
| Research Area | Cell Adhesion |
| Gene Names | MAG |
| Protein Names | Recommended name: Myelin-associated glycoproteinAlternative name(s): Siglec-4a |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. |
| Target Details | This protein is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. |
| HGNC | 28157 |
| RGD | 1565703 |
| MGI | 3603816 |
| Function | Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity). |
| Involvement in disease | Spastic paraplegia 75, autosomal recessive (SPG75) |
| Subcellular Location | Cell membrane, Single-pass type I membrane protein, Membrane raft |
| Protein Families | Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family |
| Tissue Specificity | Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures (PubMed:9495552, PubMed:6200494). Detected in optic nerve, in oligodendroglia and in p |
| Database Links |
HGNC: 6783 OMIM: 159460 KEGG: hsa:4099 STRING: 9606.ENSP00000376048 UniGene: Hs.643440 |
| Pathway | Inhibitors of axonal regeneration |
| Product Name | Recombinant Human Myelin-associated glycoprotein(MAG),Baculovirus |
| Code | CSB-BP013322HU |
| Size | Pls inquiry other sizes |
| Source | Baculovirus |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
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| Sequence | GHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGP |
| Expression Region | 20-516aa |
| Protein Description | Extracellular domain |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Human Myelin-associated glycoprotein(MAG),Mammalian cell |
| Code | CSB-MP013322HU |
| Size | Pls inquiry other sizes |
| Source | Mammalian cell |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | GHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGP |
| Expression Region | 20-516aa |
| Protein Description | Extracellular domain |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
MAG Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA013322LD01HU | MAG Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA013322LC01HU | MAG Antibody, FITC conjugated | Human | ELISA |
| CSB-PA013322LB01HU | MAG Antibody, HRP conjugated | Human | ELISA |
| CSB-PA013322LA01HU | MAG Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF |
MAG Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA006022 | MAG Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA951068 | MAG Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA643161 | MAG Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
MAG Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP013322HU | Recombinant Human Myelin-associated glycoprotein(MAG),partial | Yeast |
| CSB-EP013322HU | Recombinant Human Myelin-associated glycoprotein(MAG),partial | E.coli |
MAG ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E17901h | Human myelin-associated glycoprotein(MAG) ELISA Kit | serum, plasma, cerebrospinal fluid (CSF) | 0.156 ng/mL |
Recombinant Human X-ray repair cross-complementing protein 5(XRCC5),partial
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Bifunctional Epoxide hydrolase 2(EPHX2)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Bisphosphoglycerate mutase(BPGM)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Glial fibrillary acidic protein(GFAP)
Express system: Yeast
Species: Mus musculus (Mouse)
Recombinant Human Sperm-egg fusion protein Juno(IZUMO1R)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4,mitochondrial(Pdk4),partial
Express system: E.coli
Species: Mus musculus (Mouse)
