Mouse C-X-C motif chemokine 13 (Cxcl13/Blc/Scyb13) ELISA kit

Instructions
Code CSB-E16832m
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name C-X-C motif chemokine 13 (Cxcl13/Blc/Scyb13)
Alternative Names Cxcl13 ELISA kit; Blc ELISA kit; Scyb13C-X-C motif chemokine 13 ELISA kit; B lymphocyte chemoattractant ELISA kit; CXC chemokine BLC ELISA kit; Small-inducible cytokine B13 ELISA kit
Abbreviation CXCL13
Uniprot No. O55038
Species Mus musculus (Mouse)
Sample Types serum, plasma, tissue homogenates, cell culture supernates
Detection Range 0.156 ng/mL-10 ng/mL
Sensitivity 0.096 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Assay Principle quantitative
Measurement Sandwich
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Background

Function
(From Uniprot)
Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.
Gene References into Functions
  1. CXCL13, upregulated by peripheral inflammation, acts on CXCR5 on dorsal root ganglia neurons and activates p38, which increases Nav1.8 current density and further contributes to the maintenance of inflammatory pain. PMID: 27708397
  2. This study indicated that CXCL13 may be pathogenically involved in Clostridium difficile infection (CDI) and served as a potential new biomarker for diagnosis and prognosis in CDI. PMID: 27685937
  3. CXCL13 has a role in directing B-lymphocyte migration PMID: 27477203
  4. CXCL13 and CXCR5 contribute to orofacial pain via ERK-mediated proinflammatory cytokines production. PMID: 27401148
  5. High glucose could inhibit osteogenic differentiation of mesenchymal stem cells by lncRNA AK028326 mediated down-regulation of CXCL13 expression. PMID: 27693963
  6. Data demonstrate that CXCL13 is not essential in mounting effective peripheral humoral responses, but specifically promotes CNS accumulation of differentiated B cells. PMID: 26795429
  7. overexpression of CXCL13 is associated with myasthenia gravis. PMID: 26771137
  8. Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated benzo(a)pyrene-induced lung cancer in mice, demonstrating CXCL13's critical role in polycyclic aromatic hydrocarbon-induced lung carcinogenesis. PMID: 26565418
  9. Blockade of CXCL13 significantly reduced urine protein, serum creatinine, and dramatically attenuated renal pathology injury in lupus nephritis in mice. PMID: 26456520
  10. Results from this study suggest blockade of CXCL13 and BAFFR together may be an effective therapeutic strategy in preventing salivary hypofunction and reducing autoantibody titers and sialadenitis in patients with Sjogren's syndrome PMID: 26826598
  11. findings reveal a neuronal/astrocytic interaction in the spinal cord by which neuronally produced CXCL13 activates astrocytes via CXCR5 to facilitate neuropathic pain. PMID: 26752644
  12. Study reports a novel role of AK141205/CXCL13 as a regulator of osteogenic growth peptide-induced osteogenic differentiation of smooth muscle cells. PMID: 26321662
  13. Data indicate that CXC chemokine CXCL13-responsive late transitional B cells are the initiating subset for the positive feedback loop. PMID: 25662995
  14. Study demonstrates that microglia are an important source of CXCL13 production in the acutely inflamed brain, and in vitro experiments confirm that type-I IFN selectively inhibits microglial production of CXCL13 in a dose-dependent manner PMID: 24829092
  15. Data suggest that Src homology 3 (SH3) protein interacting with NcK, 90 kDa (SPIN90)plays an important role in B cell immune responses through the regulation of chemokine CXCL13-mediated B cell migration. PMID: 24965518
  16. mediates vaccine-induced immunity against tuberculosis PMID: 23299616
  17. CXCL13 may be pathogenically involved in SS and may serve as a new marker and a potential therapeutic target. PMID: 23904442
  18. CXCL13 is produced within lymphoid follicles of patients with COPD and is crucial for the formation of TLOs. PMID: 23742729
  19. Late stage cathepsin C, CXCL13 and Ki-67 overexpression correlate with regional neuropathology in a bovine spongiform encephalopathy transgenic murine model. PMID: 22789860
  20. Interruption of CXCL13-CXCR5 axis increases upper genital tract pathology and activation of NKT cells following chlamydial genital infection. PMID: 23189125
  21. Data show that CXCL13/CXCR5 facilitated antigen encounter and BCR signaling by promoting membrane ruffling and LFA-1-supported adhesion require a functional actin cytoskeleton and the activity of the motor protein non-muscle myosin II (NM-II). PMID: 21659539
  22. LTBR-pathway in Sjogren's syndrome: CXCL13 levels and B-cell-enriched ectopic lymphoid aggregates in NOD mouse lacrimal glands are dependent on LTBR. PMID: 21153342
  23. found enhanced plasma levels of CXCL13 in lupus-prone MRL/lpr and NZB/W-F1 mice PMID: 21084753
  24. Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues PMID: 20304952
  25. Disease-associated B lymphocyte selection into islets occurs despite CXCL13 blockade- induced disruption of their structural organization; loss of B cell organization in islets do not provide disease protection. PMID: 20574003
  26. elevated expression and different distribution in the aged spleen PMID: 19845796
  27. New putative control elements in the promoter OF CXCL13 chemokine gene, a target of alternative NF-kappaB pathway PMID: 19807029
  28. CXCL13 is essential for the spatial arrangement of lymphocytes within granulomas, optimal activation of phagocytes, and subsequent control of mycobacterial growth. PMID: 19933855
  29. A subset of dendritic cells expressing CXCR5 migrate rapidly into the primary lymphoid follicles from the marginal zone in response to CXC ligand 13 (B lymphocyte chemoattractant, CXCL13) via a B cell-derived, membrane lymphotoxin-dependent mechanism. PMID: 11994465
  30. CXCR5/CXCL13 signaling activates alpha4beta1 integrin on CD4+CD3- cells. PMID: 12354388
  31. its aberrant high expression is a cause of SLE--review PMID: 12518463
  32. CXCL13 expressed in the high endothelial venule lumen plays a crucial role in B cell trafficking into secondary lymphoid tissues such as Peyer's patches. PMID: 12902460
  33. The tissue architecture of the lymphoid clusters induced in the chronic lesion of autoimmune gastritis is supported by a typical lymphoid reticular network and follicular dendritic cells expressing the B cell homing chemokine, CXC chemokine ligand 13. PMID: 14530361
  34. This experiment find that gene expression of CXCL13, a chemokine involved in B-cell recruitment into lymphoid follicles.the presence of lymphoid follicle-like structures containing B cells. PMID: 14975582
  35. data identify CXCL13 as an arrest chemokine for B cells in high endothelial venules and that CXCL13 plays an important role in B-cell entry into not only Peyer patches but also mesenteric lymph nodes PMID: 15972452
  36. B-cell defects in the nasal-associated lymphoid tissue of lymphotoxin(-/-) mice can be attributed to the impaired expression of CXCL13. PMID: 16210592
  37. double-negative (DN) Treg cells preferentially express Burkitt lymphoma receptor 1, and interaction of this chemokine receptor with its ligand CXCL13 plays an important role in DN Treg cell migration both in vitro and in vivo PMID: 16621993
  38. CXCL13 plays a pathogenic role in experimental autoimmune encephalomyelitis, particularly during the effector phase. PMID: 16751415
  39. ability of CXCL13 and sphingosine1-phosphate to direct the trafficking and localization of B cells in vivo may be dependent on Rap activation PMID: 16821235
  40. Pulmonary expression of Cxcl13 is essential for local immunity to influenza. PMID: 17563386
  41. study shows CCL21 & CXCL13 are transiently down-regulated in lymphoid tissues during immune responses by a mechanism controlled by interferon-gamma; the modulation altered localization of lymphocytes & dendritic cells within responding lymphoid tissues PMID: 17673664
  42. Survival after UVA irradiation was greater in human keratinocytes compared to mouse skin with no S100A2 expression, showing a protective role for S100A2. A S100A2-dependent difference was observed in the induction of Cxcl13 transcripts in transgenic mice. PMID: 18773213
  43. The activation of both canonical and non-canonical nuclear factor-kappaB (NF-kappaB) pathways was essential for CXCL13 induction. PMID: 19251935
  44. Unlike conventional lymphoid organs, milky spots in the omentum developed in the absence of lymphoid tissue-inducer cells, but required the chemokine CXCL13 PMID: 19427241
  45. RA induces CXCL13 expression and is essential for lymph node formation. PMID: 19783990

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Subcellular Location Secreted
Protein Families Intercrine alpha (chemokine CxC) family
Tissue Specificity Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).
Database Links

KEGG: mmu:55985

STRING: 10090.ENSMUSP00000023840

UniGene: Mm.10116

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