Gene References into Functions |
- Compared to WT leukocytes, CtsB(-/-) leukocytes accumulated in a higher number in angiogenic vessels, but extravasated less toward the implanted cytokine. The accumulated CtsB(-/-) leukocytes in angiogenic vessels expressed more CD18. PMID: 28904019
- CatB aggravates Coxsackievirus B3-induced viral myocarditis(VMC) probably through activating the inflammasome and promoting pyroptosis. This finding might provide a novel strategy for VMC treatment. PMID: 29360865
- Activation of the proteases in macrophage occurs during endocytosis of zymogen-containing vesicles, and depends on pH and CTSB in acute necrotizing pancreatitis. PMID: 29079517
- Acid ceramidase inhibitor LCL521 targets lysosomes to activate cathepsin B and cathepsin D, resulting in interrupted autophagy and ER stress that culminates in myeloid-suppressor cell death. PMID: 27880732
- Using quenched activity-based probes, we identified mouse cathepsin B (CtsB), which is expressed in the lower regions of the hair follicle, as an additional target of mouse Cst6 PMID: 28596234
- After phagocytosis, particles can disrupt lysosomes, and inhibitor studies have suggested that the resulting release of a lysosomal protease-cathepsin B-into the cytosol somehow activates NLRP3. PMID: 28087651
- ctsB enhanced neutrophil migration though a putative effect on pseudopod retraction rates. PMID: 28389621
- the roles of CTSB/S and SIRT1 in the regulation of hepatic inflammation using primary parenchymal and non-parenchymal hepatic cell types and cell lines. PMID: 27831566
- Mice and macrophages lacking cathepsin B activity had increased resistance to the cytosolic bacterial pathogen Francisella novicida Genetic deletion. PMID: 27551156
- in CTSB knockout (KO) mice, running did not enhance adult hippocampal neurogenesis and spatial memory function. Interestingly, in Rhesus monkeys and humans, treadmill exercise elevated CTSB in plasma. PMID: 27345423
- Exposure of J774A.1 cells to HOCl or HOSCN resulted in a significant decrease in the activity of the Cys-dependent cathepsins B and L, but not the Asp-dependent cathepsin D. PMID: 27997605
- cathepsin B (CTSB) inhibition or expression of a CTSB-resistant Dab2 mutant maintains Dab2 expression and shifts long-term TGF-beta-treated cells from autophagy to apoptosis PMID: 27398911
- study brings forth a yet unappreciated role for Cathepsin B in regulating T cell responses during Leishmania major infection PMID: 27182703
- Our results suggest that the Mucopolysaccharidosis type I mice have progressive heart failure and valve disease, which may be caused by cathepsin B overexpression. PMID: 28104572
- CTSB in pancreatitis undergoes activation in a secretory, vesicular, and acidic compartment where it activates trypsinogen. Its deletion or inhibition regulates acinar cell apoptosis but not necrosis in two models of pancreatitis PMID: 27226576
- IGF-1 promotes the growth and metastasis of hepatocellular carcinoma by inhibition of proteasome-mediated cathepsin B degradation. PMID: 26401078
- We therefore conclude that CD in pancreatic acinar cells is implicated in CB and CL degradation but not in autophagic activity. PMID: 26682926
- Aggregatibacter actinomycetemcomitans invasion of macrophages induces interleukin-1beta production through reactive oxygen species and cathepsin B. PMID: 25789553
- Findings indicate that Ctsb-/- BMDC display more pro-Th1 properties than their WT and Ctsl-/- counterparts, and therefore suggest that Ctsb down-regulates the Th1 response to L. major. PMID: 25255101
- Cathepsin B showed the highest protein levels in the anterior segments of the gastrointestinal tract, whereas the highest activity was observed in the jejunum PMID: 25205730
- CtsB and CtsL are essential in alpha-syn lysosomal degradation PMID: 26170293
- Reactive oxygen species and cathepsin B activities are necessary for maximal iNOS induction in C. muridarum-infected macrophages. PMID: 26015483
- CTSB protein functions as a necessary modulator of hypertrophic response by regulating TNF-alpha/ASK1/JNK signaling pathway involved in cardiac remodeling. PMID: 25713304
- Abeta oligomers, but not fibrils, induce IL-1beta production in primary microglia in a cathepsin B- and reactive oxygen species -dependent manner. PMID: 25680460
- data illustrate the role of CatB in producing pGlu-Abeta and flAbeta that participate as key factors in the development of Alzheimer's disease PMID: 24595198
- cysteine cathepsins B and S can directly cleave Rip1 PMID: 24799565
- The increase in cathepsins B and L activities in lymphosarcoma tissues is caused by cyclophosphamide induction of apoptosis. PMID: 24319737
- Cathepsin B produces full-length amyloid-beta (Ab(1-40/42)) and pyroglutamate amyloid-beta (pyroGluAb(3-40/42) and is a key drug target for treating Alzheimer's disease by reducing these amyloid-beta species PMID: 24595198
- High cathepsin expression is associated with dysplasia and colitis-associated cancer. PMID: 23591598
- High cathepsin B expression is associated with glioma. PMID: 22495828
- Cathepsin B is a novel gender-dependent determinant of cholesterol absorption from the intestine. PMID: 23248330
- Results indicate influence of both Ctsb and Ctsl on the skin proteome and degradome, with the phenotypic consequences of the absence of either protease differing considerably. PMID: 23233448
- Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants PMID: 23297415
- These results show that CatB and CatL activity is not required for ebola virus replication. PMID: 23236527
- Relative position of thyroglobulin (Tg)peptide epitopes are identified based on homology to known Ctsb cleavage sites in rabbit Tg. PMID: 23315080
- Enhancing neuronal CatB activity in hAPP(WT) mice significantly lowered Abeta42 levels. PMID: 23024364
- We demonstrate that ATP, acting through the P2X7 receptor, induces release of cathepsin B into the extracellular space where it degrades TIMP-1, permitting the MMP-9-dependent migration of glial cells. PMID: 23017058
- This study provided that initiation animal disease model peripheral inflammation-induced chronic pain contribute by Microglial cathepsin B. PMID: 22895716
- Data suggest that during development of obesity, lipotoxic lipids trigger Ctsb-dependent lysosomal permeabilization in adipocytes; Ctsb induces mitochondrial dysfunction, ROS production, cell death, and recruitment of macrophages into adipose tissue. PMID: 22739104
- up-regulation of endothelial CTSB due to Fli1 deficiency may contribute to the development of SSc vasculopathy PMID: 22384200
- Knockout of the CatB gene in the AbetaPPWT/Lon mice improved memory deficits and altered the pattern of Abeta-related biomarkers in a manner consistent with CatB having WT beta-secretase activity. PMID: 22337825
- plays an important cell autonomous role in the progression of pancreatic ductal adenocarcinoma PMID: 22157328
- between mRNA expression and activity of beta-secretase, cathepsin D, and cathepsin B in the brain of SAMR1 and SAMP8 with age. PMID: 22008266
- A rise in lysosomal pH has been proposed as the trigger of ATP-dependent lysosomal secretion of cathepsin B in this murine pneumococcal meningitis model. PMID: 22003197
- Ctsb has significant effects on emotionality PMID: 21897848
- Findings point to a role for cathepsin D and B in cell debris degradation after apoptotic processes rather than promoting cell death, as proposed for other developmental models. PMID: 21648018
- The expression of cathepsins D and B in the murine ectoplacental cone was correlated with the ultrastructural progress of decidual invasion by trophoblast cells. PMID: 21116106
- data suggest that subcellular redistribution of cathepsin B, in itself, induces neither spontaneous trypsinogen activation nor pancreatitis PMID: 21081800
- Results suggest P2X(7)R activation may play a novel and direct role in tissue damage through release of cathepsins. PMID: 20639492
- These observations strongly suggest that CB plays a critical role in axotomy-induced mortor neuron death in adult mice. PMID: 20673755
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