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Cathepsin B (CTSB) is a lysosomal endo- and exopeptidase in humans that is encoded by the CTSB gene. CTSB belongs to papain superfamily. It is originally synthesized as an inactive pre-procathepsin B, which matures via multiple procedures, including the co-translational removal of the pre-peptide, translocation to Golgi-apparatus for the cleavage of the pro-part, and the glycosylation of the mature form. The mature CTSB is transported to the lysosome through the M6P (mannose-6-phosphate). It is widely expressed in various tissues and cells, including in the brain.
CTSB is bilobal in shape, with a catalytic site located at the interface between the two lobes. The catalytic region is a triad composed of the amino acids cysteine, histidine, and aspartic acid, and the interaction between cysteine on the left lobe and histidine on the right lobe catalyzes peptide bond cleavage. Different from other cathepsins, CTSB contains an 18 amino acid occluding loop lying between Pro107 and Asp124. Two salt bridges between the occluding and the mature enzyme partially block the substrate-binding cleft, thus promoting its peptidyldipeptidase activity.
In terms of coronavirus entry into the host cell, CTSB facilitates the activation of spike glycoprotein in the endosomal pathway.
As a lysosomal protease, CTSB is involved in several cellular degradation processes such as the degradation of protein & extracellular matrix, regulatory mechanisms, apoptosis, autophagy, and antigen representation. CTSB is also implicated in the pathology of chronic inflammatory diseases of airways and joints, cancer, and pancreatitis. CTSB has been proposed as a potentially effective biomarker for various cancers. Overexpression of CTSB is correlated with invasive and metastatic cancers. Recent studies show that CTSB executes other cellular programs such as controlling tumor growth, migration, invasion, angiogenesis, and metastases development. Moreover, the level of CTSB transcription and expression is positively correlated with the prognosis of the tumor.
Hot products of CTSB:
Recombinant Human Cathepsin B (CTSB), partial (Active) (C-terminal 6xHis-tagged) (CSB-AP005381HU)
Recombinant Human Cathepsin B (CTSB), partial (N-terminal GST-tagged) (CSB-EP006185HU1)
CTSB Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA06974A0Rb | CTSB Antibody |
Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA06974B0Rb | CTSB Antibody, HRP conjugated |
Human | ELISA |
CSB-PA06974C0Rb | CTSB Antibody, FITC conjugated |
Human | ELISA |
CSB-PA06974D0Rb | CTSB Antibody, Biotin conjugated |
Human | ELISA |
CSB-PA006185GA01HU | CTSB Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA001296 | CTSB Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA047604 | CTSB Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-PA825136 | CTSB Antibody |
Human,Mouse,Rat | ELISA,IHC |
CTSB Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-YP006185SH CSB-EP006185SH CSB-BP006185SH CSB-MP006185SH CSB-EP006185SH-B |
Recombinant Sheep Cathepsin B(CTSB) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP006185MO CSB-EP006185MO CSB-BP006185MO CSB-MP006185MO CSB-EP006185MO-B |
Recombinant Mouse Cathepsin B(Ctsb) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP006185CH CSB-EP006185CH CSB-BP006185CH CSB-MP006185CH CSB-EP006185CH-B |
Recombinant Chicken Cathepsin B(CTSB) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP006185RA CSB-EP006185RA CSB-BP006185RA CSB-MP006185RA CSB-EP006185RA-B |
Recombinant Rat Cathepsin B(Ctsb) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP006185HU CSB-EP006185HU CSB-BP006185HU CSB-MP006185HU CSB-EP006185HU-B |
Recombinant Human Cathepsin B(CTSB) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP006185HU1 | Recombinant Human Cathepsin B(CTSB),partial |
E.coli |
CSB-AP005381HU | Recombinant Human Cathepsin B(CTSB),partial (Active) |
Mammalian cell |
CTSB Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP006185BO CSB-EP006185BO CSB-BP006185BO CSB-MP006185BO CSB-EP006185BO-B |
Recombinant Bovine Cathepsin B(CTSB) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP006185PI CSB-EP006185PI CSB-BP006185PI CSB-MP006185PI CSB-EP006185PI-B |
Recombinant Pig Cathepsin B(CTSB) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
Code | Product Name | Source |
---|---|---|
CSB-YP006185DXJ CSB-EP006185DXJ CSB-BP006185DXJ CSB-MP006185DXJ CSB-EP006185DXJ-B |
Recombinant Coturnix coturnix japonica Cathepsin B(CTSB) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Dictyostelium discoideum (Slime mold)
Code | Product Name | Source |
---|---|---|
CSB-YP006185DKK CSB-EP006185DKK CSB-BP006185DKK CSB-MP006185DKK CSB-EP006185DKK-B |
Recombinant Dictyostelium discoideum Cathepsin B(ctsB) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP006185PYX CSB-EP006185PYX CSB-BP006185PYX CSB-MP006185PYX CSB-EP006185PYX-B |
Recombinant Pongo abelii Cathepsin B(CTSB) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Code | Product Name | Source |
---|---|---|
CSB-YP006185MOV CSB-EP006185MOV CSB-BP006185MOV CSB-MP006185MOV CSB-EP006185MOV-B |
Recombinant Macaca fascicularis Cathepsin B(CTSB) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL006185MO | Mouse Cathepsin B(CTSB) ELISA kit |
serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |
CTSB ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL006185RA | Rat Cathepsin B(CTSB) ELISA kit |
serum, plasma, tissue homogenates, cell lysates | 4.67 ng/mL |
CTSB ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E13450h | Human cathepsin B (CTSB) ELISA kit |
serum, plasma, tissue homogenates | 0.078 ng/mL |