Cathepsin B (CTSB), a lysosomal cysteine protease encoded by the CTSB gene, plays dual roles in intracellular protein degradation and extracellular matrix remodeling. Also known as APPS or CPSB, it functions as both an endopeptidase and exopeptidase, activated in acidic environments. CTSB regulates critical pathways including NF-κB signaling, TGF-β-mediated EMT, and PI3K/AKT/mTOR cascades, influencing tumor invasion, angiogenesis, and apoptosis. Its overexpression correlates with aggressive cancers (glioblastoma, pancreatic adenocarcinoma), neurodegenerative disorders (Alzheimer's disease via amyloid-β processing), and inflammatory conditions (rheumatoid arthritis). Pharmaceutical targeting focuses on selective inhibitors like CA-074 and its prodrugs, which have shown preclinical efficacy in reducing metastasis and chemotherapy resistance. Recent phase I trials explore CTSB inhibitors combined with immunotherapies, leveraging its role in modulating tumor microenvironment antigen presentation. Paradoxically, CTSB deficiency exacerbates atherosclerosis through impaired lipoprotein processing, highlighting context-dependent therapeutic implications.
Recombinant Human Cathepsin B (CTSB), partial (CSB-EP006185HU1e1)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CTSB Antibody (CSB-PA06974A0Rb)
Validated Data
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA06974A0Rb at dilution of 1:100
Western Blot
Positive WB detected in: Mouse heart tissue, Mouse liver tissue
All lanes: CTSB antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38 kDa
Observed band size: 38 kDa
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA06974A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA06974A0Rb at dilution of 1:100
Immunofluorescent analysis of A375 cells using CSB-PA06974A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human cathepsin B (CTSB) ELISA kit (CSB-E13450h)
Validated Data
Code: CSB-E13450h
Size: 96T,5×96T,10×96T
Sensitivity: 0.078 ng/mL
Detection Range: 0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following CTSB reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CTSB Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA06974A0Rb | CTSB Antibody | Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA06974B0Rb | CTSB Antibody, HRP conjugated | Human | ELISA |
CSB-PA06974C0Rb | CTSB Antibody, FITC conjugated | Human | |
CSB-PA06974D0Rb | CTSB Antibody, Biotin conjugated | Human | ELISA |
CSB-PA006185GA01HU | CTSB Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA001296 | CTSB Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA047604 | CTSB Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA825136 | CTSB Antibody | Human,Mouse,Rat | ELISA,IHC |
CTSB Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-YP006185SH CSB-EP006185SH CSB-BP006185SH CSB-MP006185SH CSB-EP006185SH-B |
Recombinant Sheep Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP006185MO CSB-EP006185MO CSB-BP006185MO CSB-MP006185MO CSB-EP006185MO-B |
Recombinant Mouse Cathepsin B (Ctsb) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP006185CH CSB-EP006185CH CSB-BP006185CH CSB-MP006185CH CSB-EP006185CH-B |
Recombinant Chicken Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP006185RA CSB-EP006185RA CSB-BP006185RA CSB-MP006185RA CSB-EP006185RA-B |
Recombinant Rat Cathepsin B (Ctsb) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-EP006185HU CSB-BP006185HU CSB-MP006185HU CSB-EP006185HU-B |
Recombinant Human Cathepsin B (CTSB) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP006185HU1 | Recombinant Human Cathepsin B (CTSB), partial | E.coli |
CSB-AP005381HU | Recombinant Human Cathepsin B (CTSB), partial (Active) | Mammalian cell |
CSB-EP006185HU1e1 | Recombinant Human Cathepsin B (CTSB), partial | E.coli |
CSB-YP006185HU | Recombinant Human Cathepsin B (CTSB) | Yeast |
CSB-MP006185HU3(M) | Recombinant Human Cathepsin B (CTSB)(L26V) | Mammalian cell |
CTSB Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP006185BO CSB-EP006185BO CSB-BP006185BO CSB-MP006185BO CSB-EP006185BO-B |
Recombinant Bovine Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP006185PI CSB-EP006185PI CSB-BP006185PI CSB-MP006185PI CSB-EP006185PI-B |
Recombinant Pig Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
Code | Product Name | Source |
---|---|---|
CSB-YP006185DXJ CSB-EP006185DXJ CSB-BP006185DXJ CSB-MP006185DXJ CSB-EP006185DXJ-B |
Recombinant Coturnix coturnix japonica Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Dictyostelium discoideum (Slime mold)
Code | Product Name | Source |
---|---|---|
CSB-YP006185DKK CSB-EP006185DKK CSB-BP006185DKK CSB-MP006185DKK CSB-EP006185DKK-B |
Recombinant Dictyostelium discoideum Cathepsin B (ctsB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP006185PYX CSB-EP006185PYX CSB-BP006185PYX CSB-MP006185PYX CSB-EP006185PYX-B |
Recombinant Pongo abelii Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Code | Product Name | Source |
---|---|---|
CSB-YP006185MOV CSB-EP006185MOV CSB-BP006185MOV CSB-MP006185MOV CSB-EP006185MOV-B |
Recombinant Macaca fascicularis Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL006185MO | Mouse Cathepsin B(CTSB) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |
CTSB ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL006185RA | Rat Cathepsin B(CTSB) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 4.67 ng/mL |
CTSB ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E13450h | Human cathepsin B (CTSB) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |