Mouse NAD-dependent deacetylase sirtuin-1(Sirt1)ELISA Kit

1. Study found little evidence that Sirt1 promotes the development of food anticipatory activity (FAA) and no evidence for the involvement of Sirt1 in the maintenance of FAA; nor much effect on body weight homeostasis during 60% timed calorie-restricted (CR) feeding over a short-term CR experiment. PMID: 29940007
2. Authors report here that SIRT1 levels were decreased in the liver in different mouse models and in cultured HSCs undergoing activation. PMID: 28919365
3. Authors concluded that miR-29b is an important regulator in the PDGF-BB-mediated VSMC phenotypic transition by targeting SIRT1. PMID: 30231015
4. In the absence of Sirt1, both embryos and placentas were small, with placentas showing abnormalities in both the labyrinthine layer and junctional zone. Sirt1-null trophoblastic stem cells showed blunted differentiation, and appeared to be suspended in an Epcam(high) trophoblast progenitor state. PMID: 29405961
5. the Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins PMID: 28504272
6. The present study has provided novel evidence to suggest that under HFD-induced metabolic surplus, the lack of SIRT1 catalytic activity promotes release of free fatty acid from mesenteric adipose tissue (MAT) and escalate nonalcoholic fatty liver disease (NAFLD) by interfering with lipid homeostasis in both liver and MAT. PMID: 28789977
7. Compared with control-diet mice, mice given an high-fat diet (HFD) for 4weeks displayed anxiolytic-like behaviors. At the same time, we observed decreased SIRT1 expression in the medial prefrontal cortex and the amygdala of HFD-fed mice. Resveratrol, an activator of SIRT1, reversed the anxiolytic-like behaviors in HFD-fed mice. PMID: 29331532
8. These findings support the unifying concept that nuclear NAD(+) sensor SIRT1 broadly coordinates innate and adaptive immune reprogramming during sepsis PMID: 30069485
9. Low SIRT1 expression is associated with Parkinson's disease. PMID: 29571747
10. SUV39H augments intracellular reactive oxygen species levels in a SIRT1-dependent manner. PMID: 28361889
11. our data strongly indicate that melatonin delays postovulatory mouse oocyte aging via a SIRT1-MnSOD-dependent pathway PMID: 29752296
12. SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF-kappaB pathway in mouse Kupffer cells. PMID: 29845302
13. Low expression of SIRT1 is associated with Human immunodeficiency virus-associated nephropathy. PMID: 29608911
14. SIRT1 levels were down-regulated in the livers in models of liver fibrosis and in activated hepatic stellate cells (HSCs) as opposed to quiescent HSCs. SIRT1 activation halted, whereas SIRT1 inhibition promoted, HSC transdifferentiation into myofibroblasts. PMID: 28970250
15. Sirt1 preserves Cav1-dependent endothelial function by mitigating miR-204-mediated vascular endoplasmic reticulum stress. PMID: 28181559
16. Nicotinamide riboside (NR) can protect against ethanol induced liver injuries via replenishing NAD(+), reducing oxidative stress, and activating SirT1-PGC-1a-mitochondrial biosynthesis. Our data indicate that SirT1 plays an important role in the protection of NR against lipid accumulation and mitochondrial dysfunctions induced by ethanol PMID: 29679894
17. These data highlight the importance of preventing the loss of 24-OH in the brain, and of maintaining high levels of the enzyme SIRT1, in order to counteract neurodegeneration. PMID: 29883958
18. the results of the present study indicated that GLP1 may be a promising target for the development of novel therapeutic strategies for HGinduced nephropathy, and may function through the activation of SIRT1 PMID: 29845208
19. In lung tissues of LPS-endotoxemia, significantly increased levels of SNO-SIRT were found. Plasma nitrite and HMGB1 levels were significantly higher than those in the sham controls. PMID: 29680657
20. targeted induction of the anti-inflammatory effects of SIRT1 and LCN2 may help prevent obesity-associated insulin resistance and neuroinflammation. PMID: 29634925
21. PE particle-induced downregulation of SIRT1 enhances ER stress. PMID: 29775898
22. During catecholamine-stimulated lipolysis, Perilipin 5 is phosphorylated by protein kinase A and forms transcriptional complexes with PGC-1alpha and SIRT1 in the nucleus. Perilipin 5 promotes PGC-1alpha co-activator function by disinhibiting SIRT1 deacetylase activity. PMID: 27554864
23. findings demonstrate a new mechanism for the activation of SIRT1 under stress conditions and suggest a novel potential therapeutic target for preventing age-related diseases and extending healthspan PMID: 29133780
24. SIRT1 was inhibited or knocked out in macrophages, the protection effect disappeared by treatment of inhibitor of mir-138, and the NFkappaB pathway was activated and the AKT pathway was inhibited PMID: 30157481
25. the results of the present study suggest that moderate overexpression of SIRT1 (~3fold of normal level) may directly or indirectly inhibit apoptosis of OBs via the FOXO1 and betacatenin signaling pathway. PMID: 29512706
26. Overexpression of miR-22 can attenuate oxidative stress injury in diabetic cardiomyopathy by upregulation of Sirt 1. PMID: 29288528
27. caloric restriction rescues SIRT1 levels in transgenic Machado-Joseph disease (MJD) mice, whereas silencing SIRT1 is sufficient to prevent the beneficial effects on MJD pathology. PMID: 27165717
28. the findings identify a gut-vascular axis in which Gut microbiota remotely upregulate miR-204 expression in the vessel wall. Among the genes targeted by miR-204 in the vascular wall is Sirt1, downregulation of which promotes endothelial dysfunction. PMID: 27586459
29. melatonin oral supplementation may represent a new protective approach to block hypercholesterolemic liver alterations involving also a SIRT1-dependent mechanism. PMID: 29516009
30. Melatonin promoted MnSOD and SIRT1 expression, which successfully ameliorated busulfan-induced SSC apoptosis caused by high concentrations of ROS and p53 PMID: 28027652
31. HO-1 regulates macrophage activation via the SIRT1-p53 signaling network and regulates hepatocellular death in liver ischemia-reperfusion injury. PMID: 28842295
32. miR-200a-3p promotes beta-amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer's disease and its animal models. PMID: 29358553
33. The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 acts as an energy sensor and negatively regulates poly(A)RNA transport via deacetylating a poly(A)-binding protein, PABP1. PMID: 28756945
34. L-Carnitine alleviated epithelial mesenchymal transformation-associated renal fibrosis caused by perfluorooctanesulfonate through a Sirt1- and PPARgamma-dependent mechanism. PMID: 28973641
35. The data, therefore, suggest that 1,25(OH)2D3 increases glucose consumption by inducing SIRT1 activation, which in turn increases IRS1 phosphorylation and GLUT4 translocation in myotubes. PMID: 29188534
36. PU.1 suppresses Sirt1 translation via transcriptional promotion of miR-34a/-29c. PMID: 29162670
37. Impairment of energy sensors, SIRT1 and AMPK, in lipid induced inflamed adipocyte is regulated by Fetuin A. PMID: 29030114
38. this study revealed a new mechanism wherein EPO alleviates hepatic steatosis by activating autophagy via SIRT1-dependent deacetylation of LC3. PMID: 29522896
39. Retinoic acid (RA) increases the expression of hepatic Sirt1 and inhibits the expression of sterol regulatory element binding protein 1c (Srebp-1c) in WT mice in vivo and in vitro. RA-mediated molecular effects are abolished in the liver and primary hepatocytes from Sirtuin 1 (Sirt1) deficient (LKO) mice. PMID: 28667519
40. thymoquinone inhibits cellular ROS generation in LPS-activated BV2 microglia. It is also suggested that activation of both AMPK and NAD(+)/SIRT1 may contribute to the anti-inflammatory, but not antioxidant activity of the compound in BV2 microglia. PMID: 28551846
41. SIRT1 signaling is important for alleviation of sepsis-induced myocardial injury and for enhancement of the protective effect of a liver X receptor agonist. PMID: 28993270
42. reduction of Sirt1 activity restores adipogenesis in Sirt7(-/-) adipocytes in vitro and in vivo PMID: 28923965
43. These results support previous work demonstrating that induction of SIRT1 in skeletal muscle, either at birth or in adulthood, does not impact muscle insulin action or mitochondrial function. PMID: 28544355
44. we identified that Sirtuin 1 (SIRT1), a deacetylase that suppresses FoxO1 acetylation in granulosa cell (GCs), was downregulated by miR-181a and reversed the promoting effects of H2O2 and miR-181a on FoxO1 acetylation and GC apoptosis. PMID: 28981116
45. the interaction of TIM4TIM1 was found to promote Th2cell proliferation through enhancing SIRT1 expression in mice with nasal allergic rhinitis. PMID: 28949386
46. retinal vasculature from diabetic Sirt1 mice did not present any increase in the number of apoptotic cells or degenerative capillaries or decrease in vascular density. Diabetic Sirt1 mice were also protected from mitochondrial damage and had normal electroretinography responses and ganglion cell layer thickness. PMID: 29311218
47. CKII-SIRT1-SM22alpha acts in a loop to reinforce the expression of SM22alpha, which limits the inflammatory response in vascular smooth muscle cells. PMID: 28419207
48. SIRT1 may increase neuron function and resilience against Alzheimer's disease PMID: 27614878
49. Regulation of stem cell aging by SIRT1 occurs via linking metabolic signaling to epigenetic modifications. (Review) PMID: 28392411
50. Data show that 66-kDa Src homology 2 domain-containing protein (p66Shc) is acetylated under high glucose conditions and is deacetylated by Sirtuin1 lysine deacetylase (Sirt1) on lysine 81. PMID: 28137876

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KEGG: mmu:93759

STRING: 10090.ENSMUSP00000020257

UniGene: Mm.351459