| Gene References into Functions |
- Our findings suggest that CNTF over-expression enhances the protective effects of bone marrow mesenchymal stem cells on retinal pigment epithelium cells, thus indicating subretinal-transplantation of CNTF-bone marrow mesenchymal stem cells may be a promising therapy for blue-light -injured retina PMID:
29564604
- Cytokines of the LIF/CNTF family and metabolism PMID:
26817395
- High hydrostatic pressure enables almost 100% refolding of recombinant human ciliary neurotrophic factor from inclusion bodies at high concentration. PMID:
28323167
- CNTFR-specific mutants of CNTF have been developed that bind to the CNTFRalpha-LIFRbeta-gp130 receptor. PMID:
26187860
- Human CNTF expression through lentiviral gene transfer in the rat striatum significantly decreased the levels of neuronal metabolites (N-acetyl-aspartate, N-acetyl-aspartyl-glutamate, and glutamate). PMID:
25833344
- the biological effects of CNTF on retinoic acid (RA)-predifferentiated SH-SY5Y neuroblastoma cells and the underlying molecular mechanism of this effect were investigated for the first time PMID:
25118897
- R28E mutation in CNTF abrogatesIL-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130/ LIFR. PMID:
24802752
- In this review, CNTF plays an important role in neurogenesis and differentiation of neural stem cells. PMID:
23948898
- The levels of expression and secretion of BDNF and CTNF of induced cells were assessed using immunocytochemical, Real-Time polymerase chain reaction, and enzyme linked immunosorbent assay (ELISA). PMID:
23944834
- CNTF elevated in umbilical cord blood from pre-eclamptic pregnancies PMID:
23654315
- CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Muller glial cells. PMID:
24191003
- Report favourable allelic patterns of ACTN3 and CNTF genes on aerobic performance in athletes. PMID:
23676962
- Data indicate that aspirin increased mRNA and protein expression of CNTF in primary mouse and human astrocytes in a dose- and time-dependent manner. PMID:
23653362
- we show that the release of CNTF by glial cells is a very powerful stimulus for optic fiber regeneration and retinal ganglion cell survival after optic nerve crush PMID:
23194670
- Ciliary neurotrophic factor levels were increased in painful PTT only. PMID:
22337942
- Peptide 6c, corresponding to human CNTF amino acid residues 147-150, induces neurogenesis, neuronal activity and proliferation of immature neurons in the dentate gyrus and improvement of spatial reference memory in mice. PMID:
20952820
- CNTF's effects on retinal pigment epithelial (RPE) physiology PMID:
21912637
- Data show that variants in CNTF were significantly associated with a lower age at onset of the eating disorders. PMID:
20219210
- The role played by CNTF in retinal cell differentiation and survival in retinal progenitors, is reported. PMID:
20428961
- Ciliary neurotrophic factor, and related (CNTF), ligands targeting the established CNTF receptor alpha, binds to sortilin with high affinity. PMID:
20584990
- In women the CNTF polymorphism (odds ratio (OR) = 2.15, 95%CI: 1.27-3.64, p = 0.004) are associated with weight gain. PMID:
19833146
- Studies indicate that leptin, CNTF, LIF and IL-6 present similar three-dimensional fold structure, interact with related class-I receptors and activate similar intracellular pathways. PMID:
19751193
- A null mutation in this protein was evaluated for a relationship to disease susceptibility and disease severity in patients with multiple sclerosis. PMID:
11857064
- Association of a null mutation in the CNTF gene with early onset of multiple sclerosis. PMID:
11890844
- Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene. PMID:
11951178
- CTNF binds to the IL-6 receptor and has a role in neuroprotection PMID:
12643274
- no evidence found to suggest that ciliary neurotrophic factor is involved in the pathogenesis of pelvic endometriosis PMID:
12890930
- Constitutive expression of cytokines in brain induces changes in gene expression characteristic of chronic inflammation leading to either temporal weight reduction (CNTF) or severe cachexia (leukemia inhibitory factor). PMID:
14715713
- Results do not support an effect of the CNTF null allele on body composition, contrary to previous findings. PMID:
14747836
- findings support the hypothesis that CNTF and leptin engage distinct CNS sites and CNTF possesses inflammatory properties distinct from leptin PMID:
15047605
- In spite of axokine gene expression in retinal pigment epithelium, no photoreceptor rescue in retinal degeneration mice. PMID:
15180291
- myogenic lineage-committed human myoblasts can dedifferentiate at a clonal level; CNTF is a novel regulator of skeletal myoblast dedifferentiation via p44/p42 MAPK pathway PMID:
15843428
- CNTF negatively regulates phototransduction, which reduces the photoresponsiveness of rods, resulting in lower electroretinogram amplitudes following light stimulus. PMID:
17192435
- Possible neuroprotective role of CNTF in the optic nerve head. PMID:
17563726
- We conclude that absence of CNTF does not increase susceptibility for neurodegenerative disorders and confirm that it does not affect onset and course of familial and sporadic ALS. PMID:
17651970
- Continuous expression of striatal CNTF at the dose mediated by the expression cassette used in this study was detrimental to transgenic mice with Huntington's disease. PMID:
18293418
- The relative treatment benefit of iloperidone compared with placebo in patients with schizophrenia is enhanced in patients homozygous G/G for the rs1800169 polymorphism of CNTF. PMID:
18303965
- In vivo and in vitro experiments implicate CNTF as an endogenous regulatory component of dopamine D2-receptor-dependent neurogenesis in the subventricular zone and the dentate gyrus of the hippocampus. (Review) PMID:
18524890
- CNTF-mediated signaling is a molecular switch for neuronal versus glial differentiation of retinal stem cells/progenitors. PMID:
18669911
- Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain PMID:
18728012
- PTP-1B constitutes a key divergent element between leptin/insulin and CNTF signaling pathways at the neuronal level. PMID:
19008309
- Certain SNP patterns in VDR and CNTF genes showed better improvement of parameters associated with the effects of low-resistance training using exercise machines as analyzed by comparison between SNP patterns and factor analysis. PMID:
19082510
- The results of this study provided further evidence that the production of ciliary neurotrophic factor by Schwann cells is markedly reduced in Charcot-Marie-Tooth type 1A neuropathy. PMID:
19525893
- Fusion of HIV-1 TAT to CNTF may have modified the CNTF capacity to induce intracellular signaling in hypothalamic neurons. PMID:
19573019
- The CNTF 1357 G --> A polymorphism explains only a small portion of the variability in the muscle strength response to training in women. PMID:
19628720
- An interaction between apoE3 and CNTF occurs with both delipidated apeE3 and apoE3 found within a lipoprotein particle in cerebrospinal fluid. This interaction potentiates the survival-promoting activity of CNTF for hippocampal neurons. PMID:
9236223
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