Recombinant Human Glial cell line-derived neurotrophic factor protein(GDNF) (Active)

Code CSB-AP002881HU
Product Type Growth Factor
Size Pls inquiry other sizesPurchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P39905
Storage Buffer 0.2 m filtered 1 x PBS, pH 7.4, with 0.05 % Tween-20 ,lyophilized
Alias hGDNF, ATF
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.1 ng/ml, corresponding to a specific activity of >5.0x107 IU/mg.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence SPDKQMAVLP RRERNRQAAA ANPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCDAAETTYD KILKNLSRNR RLVSDKVGQA CCRPIAFDDD LSFLDDNLVY HILRKHSAKR CGCI
Research Area Neuroscience?
Source E.coli
Gene Names GDNF
Expression Region 78-211aa
Product Info Tag-Free
Mol. Weight 30.1 kDa
Protein Description Full Length of Mature Protein
PubMed ID 8493557; 7867768; 15372022; 15489334; 10366742; 9811930; 8988018; 22081608; 9359036; 19478429; 8968758; 8896568; 8896569; 9497256; 10917288
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Function Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
Involvement in disease Hirschsprung disease 3 (HSCR3); Congenital central hypoventilation syndrome (CCHS); Pheochromocytoma (PCC)
Subcellular Location Secreted
Protein Families TGF-beta family, GDNF subfamily
Tissue Specificity In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic
Database Links

HGNC: 4232

OMIM: 171300

KEGG: hsa:2668

STRING: 9606.ENSP00000409007

UniGene: Hs.248114

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