Recombinant Human Inhibin beta A chain(INHBA) (Active)

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Code CSB-AP004011HU
Size US$4752Purchase it in Cusabio online store
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity The ED50 as determined by its ability to binding Activin IIB used funtional ELISA is 26.3 ug/ml when Activin A 1ug/ml in a solid phases.
Target Names INHBA
Uniprot No. P08476
Research Area Immunology
Alternative Names Activin beta-A chain; EDF; Erythroid differentiation factor; Erythroid differentiation protein; Follicle stimulating hormone releasing protein; FRP; FSH releasing protein; INHBA; INHBA_HUMAN; Inhibin beta A chain; Inhibin beta A subunit; Inhibin, beta 1; Inhibin, beta A (activin A, activin AB alpha polypeptide)
Species Homo sapiens (Human)
Source Mammalian cell
Expression Region 311-426aa
Complete Sequence GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
Mol. Weight 13 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Gene References into Functions
  1. pro-activin A share features seen in the pro-TGF-beta1 and pro-BMP-9 structures. PMID: 27373274
  2. Data suggest that activin A (INHBA) plays roles in inflammation, tissue repair, fibrosis, neoplastic activation of myofibroblasts, and leiomyoma development/growth. [REVIEW] PMID: 29100238
  3. that high expression of INHBA was associated with poor response to therapy for de novo AML, and it can serve as an adverse prognostic factor for this malignancy. PMID: 28836868
  4. Activin-A may induce fibrosis in NASH and alcoholic cirrhosis via activation of Kupffer cells to express pro-inflammatory molecules that promote HSC-dependent fibrogenesis and could be a target for future anti-fibrotic therapies. PMID: 29287776
  5. Our study provided experimental and clinical evidence for the involvement of activin A and ALK4 in the pathophysiology of atrial fibrosis and atrial fibrillation PMID: 28639003
  6. INHBA gene expression in gastric cancer tissue is considered a useful independent predictor of outcomes in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1. PMID: 28652421
  7. Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle. (Review) PMID: 27756855
  8. The present study was undertaken to evaluate the distribution of the FSHB -211 G/T in men with normal or abnormal sperm parameters from Southern Italy to assess its functional relevance on the serum levels of reproductive hormones and on sperm parameters in men. PMID: 28281143
  9. binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity. PMID: 26215835
  10. analysis of a novel SMAD-independent pathway linking enhanced activin B signaling to reduced E-cadherin expression and increased migration in type II endometrial cancer PMID: 27223076
  11. High INHBA expression is associated with lung adenocarcinoma. PMID: 26950277
  12. activin A signaling has a role in melanoma growth and metastasis through immune evasion PMID: 28844941
  13. These data provide evidence that eosinophils release activin A and that this function is enhanced when eosinophils are present in an allergen-induced inflammatory environment. PMID: 27001469
  14. These results demonstrate that activin induces skin carcinogenesis via attraction and reprogramming of macrophages and identify novel activin targets involved in tumor formation. PMID: 27932444
  15. our results defined a novel pathway in which dysregulation of the RUNX2/INHBA axis due to miR-376c downregulation fosters lymph node metastasis in head and neck squamous cell carcinoma PMID: 27760788
  16. The activin-A to follistatin ratio may play a role in determining the clinical phenotype of preterm birth as preterm labor or preterm premature rupture of membranes. PMID: 27159193
  17. A screen of a human protein library identified activin A as a potent regulator of follicular helper T cells cell differentiation. PMID: 27376469
  18. Activin A is higher in patients with steatohepatitis than both lean and obese controls PMID: 27621190
  19. INHBA expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
  20. Activin A and preeclamptic serum upregulate ET-1, ICAM-1, and VCAM-1 in human umbilical vein endothelial cells, consistent with activin A contributing to the pathophysiology of preeclampsia. PMID: 27155341
  21. Data show that dedifferentiated chondrocytes can be redifferentiated following treatment with the chimeric erythroid differentiation factor (activin A)/bone morphogenetic protein 2 (BMP2) ligand AB235. PMID: 26563344
  22. Study shows that INHBA and FST are induced by seminal fluid in cervical tissues and thus, may contribute to regulation of the post-coital response in women. PMID: 26415587
  23. Inhibin betaA is translationally regulated by TGFbeta via hnRNP E1. PMID: 26096938
  24. we show a role for autocrine Activin signaling in the regulation of colony formation, cell migration and invasion in Barrett's tumorigenesis. PMID: 26447543
  25. Our study uncovers the PITX2-induced expression of TGFB1/2/3 as well as INHBA genes (p < 0.01) followed by SMAD2/3-dependent TGF-b signalling pathway in ovarian cancer cells PMID: 26298390
  26. changes in Follistatin levels during pregnancy contribute to the control of the activin A system PMID: 25565002
  27. Overexpression of activin A in OSCCs, which is controlled by downregulation of miR-143/miR-145 cluster, regulates apoptosis, proliferation and invasiveness, and it is clinically correlated with lymph node metastasis and poor survival. PMID: 26317418
  28. Activin A inhibited signaling by BMP-6 and BMP-9 by competing for type 2 receptors ACVR2A and ACVR2B. PMID: 26047946
  29. Data suggest that activin A [plus bone morphogenic protein 4 (BMP4)] strongly stimulates germ cell differentiation potential of human embryonic stem cells; this stimulation appear to depend on gene expression regulation by activin A. PMID: 25634576
  30. Increased serum level of activin A indicates its role in the pathogenesis of asthma, particularly in underweight and overweight patients. PMID: 25729977
  31. Data suggest that an SNP in promoter region of ACVR2A (activin A receptor type IIA; rs1424954, the pre-eclampsia susceptibility allele) down-regulates signal transduction in trophoblasts in response to excess activin-A (as seen in pre-eclampsia). PMID: 25659497
  32. able to restore glucose-stimulated insulin secretion in islets from type 2 diabetic donors PMID: 25833251
  33. our study suggests that increased circulating concentrations of ActA may contribute to the development of cachexia in cancer patients. PMID: 25751105
  34. Low activin-A expression was correlated with the occurrence, development, metastasis and malignant degree of lung adenocarcinoma. PMID: 25796148
  35. Data suggest that activin A (dimer of INHBA), especially in lateral hypothalamus, plays role in neuronal sensing of free amino acids, appetite regulation, and neuronal plasticity. [REVIEW] PMID: 25200295
  36. Activin-A and -B are abundantly expressed in mesothelioma tumor tissue. PMID: 25557874
  37. INHBA overexpression implies adverse clinical outcomes for urothelial carcinoma, justifying it is a potential prognostic biomarker and a novel therapeutic target in UC PMID: 25488476
  38. overexpression of INHBA in mesenchymal cells increases colony formation potential of epithelial cells, suggesting that it contributes to the dynamic reciprocity between breast mesenchymal and epithelial cells. PMID: 24916766
  39. Activin A promoted chemotaxis, migration and proliferation of human periodontal ligament cells, and caused an increase in fibroblastic differentiation of these cells while down-regulating their osteoblastic differentiation. PMID: 24928494
  40. High activin A signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer. PMID: 25449777
  41. Activin A is an anti-lymphangiogenic factor, but because of its pleiotropic effects on cell mobility it appears not suitable as a pharmacological target. PMID: 25084052
  42. Activin A, B, and AB have similar effects on steroidogenesis in human granulosa cells; in contrast, activin AC is not biologically active and does not act as a competitive antagonist. PMID: 25062451
  43. expression of erythroid differentiation regulator 1 was negatively correlated with the malignant potential in various skin tumors. PMID: 24168163
  44. Endothelial cells initiate a smooth muscle cell differentiation program in adjacent adipose stromal cells via induction activin A expression. PMID: 25114097
  45. We identified an unreported germline mutation of the INHA gene encoding the alpha-subunit, the partner of the betaA-subunit. This mutation also alters the secreted activin/inhibin ratio, by disrupting both inhibin A and inhibin B biosynthesis. PMID: 24302632
  46. Circulating activin A levels are associated with impaired myocardial glucose metabolism and high left ventricular mass/volume ratio in men with uncomplicated type 2 diabetes, reflecting a potential detrimental role in early human diabetic cardiomyopathy. PMID: 24134550
  47. Follistatin, by its ability to neutralize the actions of activin A may be of value as an antifibrotic for radiation induced fibrosis. PMID: 24204752
  48. the Activin/ALK4 pathway directly recruits PTP1B and stimulates its release from the endoplasmic reticulum through ALK4-mediated cleavage. PMID: 24139759
  49. Activin A released from EAT-T2D inhibits insulin action via the induction of miR-143 in cardiomyocytes PMID: 23812417
  50. Overexpression of the INHBA gene is considered a useful independent predictor of outcomes in patients with gastric cancer after curative surgery. PMID: 24778035
  51. Data show that expression of activin A and B was increased in many cancer cell lines. PMID: 24378873
  52. The present study suggests that INHBA is useful as a predictive marker for prognosis in colorectal cancer patients. PMID: 24085226
  53. Activin A suppresses osteoblast mineralization capacity by altering extracellular matrix composition and impairing matrix vesicle production. PMID: 23781072
  54. Urine Activin A in preterm infants who developed intraventricular hemorrhage was significantly higher than in controls at all monitoring time-points, increasing progressively from first urination to 24 h when it reached the highest peak. PMID: 23808611
  55. IFN-gamma modulates NF-kappaB/c-Jun to antagonize activin A-mediated NF-E2 transcriptional activity on erythroid cell globin gene expression PMID: 24336657
  56. Activin A, produced during NK-DC interactions, represents a relevant negative feedback mechanism that might function to prevent excessive immune activation by DCs. PMID: 24395917
  57. retinoid signalling can potently suppress activin-induced proliferation by antagonising G1 phase progression and entry into the cell cycle. PMID: 23831638
  58. Recombinant human activin A increases mature mast cell numbers in vivo in mouse skin via attraction of mast cell progenitors from bone marrow. PMID: 24227781
  59. Screening by maternal characteristics and activin-A at 30-33 weeks identifies half of the pregnancies that will subsequently develop preeclampsia. PMID: 23205865
  60. The activin A signals via SMAD proteins, but not TAK1 or p38, to regulate murine and ovine Fshb transcription in gonadotrope-like cells. PMID: 22549017
  61. Mineralization induction by 1alpha,25(OH)2 D3 may actually be controlled via interplay with activin A and osteocalcin. PMID: 23589129
  62. Activin A levels were significantly higher in hypoxic than nonhypoxic newborns and in male newborns. PMID: 22439617
  63. The study shows the involvement of activin A pathway in preterm premature rupture of the membranes associated with acute chorioamnionitis. PMID: 22845186
  64. Activin A promotes the induction of mesoderm, as indicated by the upregulation of Brachyury expression. PMID: 22548442
  65. The present study demonstrated that serum activin A is not significantly altered in peritoneal or deep infiltrating endometriosis and has limited diagnostic accuracy in the diagnosis of ovarian endometrioma. PMID: 22416010
  66. Activin A stimulates AKR1C3 expression and growth in human prostate cancer PMID: 23024260
  67. In patients with T2DM, increased activin A may reflect chronic underlying pathophysiological processes involved in development of cardiovascular disease. PMID: 22234949
  68. Plasma and placental productions of Activin A were significantly higher in preeclamptic patients when compared with normal pregnant subjects in a Chinese Han population PMID: 22685232
  69. The overarching hypothesis is that insensitivity to the growth inhibitory effects of activin A is an acquired capability in prostate cancer progression. PMID: 22579070
  70. Inhibin and activin beta subunits aree clearly demonstrable throughout the adult human hypothalamus and basal forebrain. PMID: 22296042
  71. INHBA may be a poor survival indicator of gastric cancer PMID: 21132402
  72. Activin A in the follicular fluid is biologically inactivated by a more than ten times surplus of follistatin. PMID: 21846490
  73. The pathological expression of activin beta A, iNOS and MUC1 by fallopian tubes bearing an ectopic pregnancy is not involved in the determination of implantation site. PMID: 22425195
  74. High Activin-A levels were found in bronchoalveolar lavage (BAL) samples from patients with acute respiratory distress syndrome (ARDS). PMID: 22161160
  75. analysis of candidate genes revealed four genes that influence fertility: CGB/LHB gene cluster (p = 0.0036), FSHR (p = 0.023), FST (p = 0.023), and INHB; none of the independent SNPs in these genes predicted mortality PMID: 21222045
  76. Activin-A was identified as strongly secreted by mesenchymal cells from control and T21 mesenchymal cells. Recombinant activin-A stimulated T21 trophoblast fusion PMID: 21952245
  77. Activin A in maternal and fetal biological fluids is increased after SSRI administration in the third trimester of pregnancy. PMID: 21767104
  78. results indicate that the coding regions of INHBA, SFRP4 and HOXA10 do not harbour mutations responsible for linkage to endometriosis in the families studied PMID: 21576276
  79. Synthesis of activin and TGFB-signaling modulators may be affected by spermatogenic disruption and altered hormone levels in the testis. PMID: 19661148
  80. Activin-A appears to promote endometriosis by stimulating interleukin-6 and protease-activated receptor-2 mRNA expression and increasing the proliferation of endometrioma stromal cells. PMID: 21640344
  81. High inhibin beta A is associated with cervical intraepithelial neoplasia grade 3 compared to cervical intraepithelial neoplasia grades 1 and 2. PMID: 21475087
  82. Study found a significant association between activin A and newly detected abnormal glucose regulation in patients with acute myocardial infarction. PMID: 21464440
  83. Activin A promotes Smad2 phosphorylation and its nuclear translocation. As an immediate response to activin A, Smad2 was modified by phosphorylation within 2 hours. PMID: 12665510
  84. Elevated plasma activin A levels are associated with the presence of carcinoid heart disease. PMID: 20720391
  85. results are consistent with a role for activin in maintaining oocyte granulosa cell interactions due to increased peripheral granulosa cell adhesion to the basement membrane and retention of adhesion at the surface of the zona pellucida. PMID: 20203128
  86. Protein levels of activin A and follistatin were assessed in glioblastoma and normal brain tissues in this study PMID: 20926007
  87. GDF9 attenuates the suppressive effects of activin A on StAR expression and progesterone production by increasing the expression of inhibin B, which acts as an activin A competitor. PMID: 20660033
  88. Overexpression of activin A is associated with oral squamous cell carcinoma. PMID: 20309641
  89. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20610541
  90. Activin A increased in asphyxiated full-term newborns with hypoxic ischemic encephalopathy before the appearance of related signs. PMID: 20036850
  91. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  92. Activin A is not a clinically useful marker of intrauterine infection in women with preterm prelabour rupture of membranes PMID: 19641514
  93. Activin A is secreted into uterine lumen; the levels in endometrial washing fluids were higher in women who subsequently became pregnant after IUI, so its measurement may be useful in predicting successful implantation. PMID: 19200970
  94. activin A signal is transduced through the activin A type 1 receptor, ALK4, and transactivates several TGF-beta target genes in a SMAD-independent manner. PMID: 20226172
  95. in ductal carcinoma in situ lesions, high COX-2 expression is associated with high gammaH2AX, TRF2, activin A, and telomere malfunction PMID: 20028875
  96. Activin A, a TGF-beta family member, is a therapeutically amenable target exploited by multiple myeloma (MM) to alter its microenvironmental niche favoring osteolysis. PMID: 20194748
  97. roles of activin A in Human embryonic stem cell proliferation and differentiation were found. PMID: 19885849
  98. down-regulated KLF4, CHGA, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA is an 8-gene signature for gastric cancer PMID: 20043075
  99. distribution in gestational tissues across human pregnancy and during labour PMID: 11969340
  100. Activin was secreted by both endometrial adenocarcinoma cell lines. Activin showed a weak, but significant, mitogenic effect on HEC-50 cells without modifications in Bax and Bcl-2. Activin is a regulator of endometrial cancer cell growth. PMID: 12088879

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Subcellular Location Secreted
Protein Families TGF-beta family
Database Links

HGNC: 6066

OMIM: 147290

KEGG: hsa:3624

STRING: 9606.ENSP00000242208

UniGene: Hs.28792

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