Recombinant Human Parathyroid hormone protein(PTH),15N Stable Isotope Labeled(Active)

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Code CSB-AP000041HU
Product Type Hormone
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P01270
Lead Time 5-10 business days
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias PTH, Parathyrin
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by its ability to induce cAMP accumulation in murine MC3T3E1 cells is less than 50 ng/ml, corresponding to a specific activity of >2.0x104 IU/mg.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNFVALGAP LAPRDAGSQR PRKKEDNVLV ESHEKSLGEA DKADVNVLTK AKSQ
Research Area Signal Transduction
Source E.coli
Gene Names PTH
Expression Region 32-115aa
Tag Info Tag-Free
Mol. Weight 9.5 kDa
Protein Description Full Length of Mature Protein
PubMed ID 6950381; 6220408; 15489334; 7829495; 4833516; 15340161; 4521809; 728431; 1125201; 4474131; 4721748; 21076856; 2069952; 8344299; 7797503; 10623601; 10837469; 18375760; 2212001; 10523031; 18056632
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Function PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
Involvement in disease Hypoparathyroidism, familial isolated (FIH)
Subcellular Location Secreted
Protein Families Parathyroid hormone family
Database Links

HGNC: 9606

OMIM: 146200

KEGG: hsa:5741

STRING: 9606.ENSP00000282091

UniGene: Hs.37045

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