Recombinant Mouse Hepatitis A virus cellular receptor 2 homolog(Havcr2),partial (Active)

1. TIM-3 expression was predominantly localized to myeloid cells in both human and murine tumors PMID: 29316433
2. Here, the authors demonstrate that Tim-3 inhibits macrophage phagocytosis of Listeria monocytogenes by inhibiting the nuclear erythroid 2-related factor 2 (Nrf2) signaling pathway and increases bacterial burden. PMID: 28205579
3. Studied role of Tim-3 role's in T cell activation using a chronic disease model. Results showed a major function of Tim-3 is to enhance T cell activation during either acute or chronic viral infection, and that Tim-3 is not required for the development of T cell exhaustion. PMID: 29463725
4. the data suggested that Tim-3 played a crucial role in the macrophage polarization and brain inflammation following intracerebral hemorrhage PMID: 29107214
5. Tim-3 might contribute to successful pregnancy by restraining Th1 bias PMID: 29083087
6. synergism in cell death by Caspase-1- and RipK3 resulted in restriction of PD-1 and TIM3 expression on primed CD8(+) T cells, which promoted the survival of activated CD8(+) T cells. PMID: 28686578
7. these findings reveal a critical role for Tim-3-Gal-9 signaling-mediated immunoregulation by pNK cells in maternal-fetal immune tolerance and suggest that Tim-3 abundance on pNK cells is a potential biomarker for recurrent miscarriage diagnosis. PMID: 28951537
8. Tim-3 and PD-1 pathways play critical roles in regulating CD8(+) T cell function and maintaining normal pregnancy. PMID: 28331165
9. CB2R may have a crucial neuroprotective role following HI insult through the modulation of the inflammatory-related HIF-1alpha/TIM-3 signalling pathway in microglia PMID: 28253997
10. Our results show that Tim-3 is a critical negative regulator of NLRP3 inflammasome and provides a potential target for intervention of diseases with uncontrolled inflammasome activation. PMID: 28799242
11. demonstrated that both IL-10 and TGF-beta upregulated TIM-3 surface expression on dendritic cells via a common signaling pathway that involved sequential activation of c-Src and Bruton's tyrosine kinase PMID: 27439518
12. Methylation level of the TIM-3 promoter gradually decreased after each round of T-cell polarization, and this decrease was inversely correlated with TIM-3 expression. PMID: 26890332
13. in mice, TIM-3 is not essential for development of HDM-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM-induced chronic allergic airway inflammation. PMID: 27209052
14. Authors found that a CD8(+) T-cell population with age-associated exhaustion was distinguishable by its expression of Tim-3. PMID: 26750587
15. TIM4 binds TIM3 on the surface of polarized Th1 cells to induce Th1 cell apoptosis, which may contribute to the development of Th2-dominant immune disorders. PMID: 26403707
16. decreases immunological rejection during composite tissue allotransplantation PMID: 26561949
17. The Gal-9/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy. PMID: 25578313
18. TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice. PMID: 26278059
19. Tim-3 acts at a receptor-proximal point to enhance Lyn kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI ligation. PMID: 26598760
20. Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer PMID: 26214042
21. TIM-3 plays a role in regulating the uterine natural killer cells and contributes to the maintenance of tolerance at the feto-maternal interface. PMID: 25897749
22. TIM-3 is highly expressed in hypoxic brain regions of a mouse cerebral hypoxia-ischaemia (H/I) model. TIM-3 is distinctively upregulated in activated microglia and astrocytes in a HIF-1-dependent manner. PMID: 25790768
23. These data identify an IL-27/NFIL3 signalling axis as a key regulator of effector T-cell responses via induction of Tim-3, IL-10 and T-cell dysfunction. PMID: 25614966
24. CD4+ T cell-dependent "negative" TIM-3 costimulation is essential for hepatic homeostasis and resistance against IR stress in OLTs PMID: 25676534
25. In DSS colitis, Tim-3 inhibited the polarization of pathogenic pro-inflammatory M1 macrophages, while Tim-3 downregulation or blockade resulted in an increased M1 response. Tim-3 effect on macrophage response may be TLR4 dependent. PMID: 26208474
26. These data suggest that Tim-3 and IFN-gamma may play a regulatory role in T. gondii-infected pregnant mouse model. PMID: 25270237
27. Gal-9, a natural TIM-3 ligand, was produced primarily by and released from ischemia-reperfusion-stressed hepatocytes, both in vivo and in vitro. PMID: 25450716
28. HCC conditioned medium or transforming growth factor-beta fostered Tim-3 expression and the alternative activation of macrophages. PMID: 25608525
29. Tim-3 induces Th2-biased immunity and macrophage activation during Schistosoma japonicum infection. PMID: 25987707
30. The Tim-3 pathway plays an inhibitory role in natural killer cell function. PMID: 25337993
31. Specific antigen-presenting cell subsets and the inhibitory receptor Tim-3 may contribute to CD8+ T cell impairment in metapneumovirus pathogenesis. PMID: 25653440
32. Tim-3 modulates microglia activity and regulates the interaction of microglia-neural cells. PMID: 25557503
33. The TIM-3 pathway ameliorates Theiler's murine encephalomyelitis virus-induced demyelinating disease. PMID: 24486565
34. CEACAM1 serves as a heterophilic ligand for TIM-3 that is required for its ability to mediate T-cell inhibition, and this interaction has a crucial role in regulating autoimmunity and anti-tumour immunity PMID: 25363763
35. Tim-3 is widely involved in the physiopathology of sepsis by regulating innate and adaptive immune responses. Blockade of the Tim-3 pathway or decreased Tim-3 expression may exacerbate sepsis by increasing immune deviation and immunosuppression in vivo. PMID: 24945079
36. Tim-3 signaling pathway acts as a novel negative mediator in LPS-induced endotoxic shock and could be a potential therapeutic target for the treatment of sepsis. PMID: 24561184
37. These results demonstrate an essential role for Btk-c-Src signaling in TIM-3-induced DC suppression. PMID: 25172495
38. The increased expression of IL-17 and Tim-3 in BALF. PMID: 23904364
39. Tim-3/galectin-9 pathway plays a critical role in the homeostasis of hepatic Tregs through the elimination induction in Teffs and the inhibition of IFN-gamma release. PMID: 24333756
40. Our findings demonstrate that Tim-3 plays an important role in brain inflammation after intracerebral hemorrhage PMID: 24289479
41. Data indicate that the absence of T cell Ig and mucin domain (Tim) 3 (Tim-3) expression impairs CD8 T cell responses to Listeria monocytogenes infection. monocytogenes PMID: 24567532
42. results indicate that the Tim-3 pathway is highly involved in the regulation of asthma; targeting Tim-3 by siRNA may hold therapeutic potential in preventing the development of allergic asthma PMID: 23232962
43. These data indicate that Tim-3 may be involved in the process of toxoplasmic encephalitis in mice infected with the Toxoplasma gondii Pru strain. PMID: 23595213
44. Anti-Tim-3 treatment augments atherosclerosis lesion development, accompanied by an increase in the number of monocytes/macrophages and CD4(+) T cells and by decreased regulatory T cells and regulatory B cells. PMID: 23990206
45. These results indicate that the therapeutic efficacy of targeting Tim-3 in experimental autoimmune encephalomyelitis is dependent on the nature of the effector T cells contributing to the disease. PMID: 23562810
46. Up-regulated expression of Tim-3 on T cells after burn injury plays an important role in the development and maintenance of burn-induced T cell immune suppression. PMID: 22038354
47. In the liver Tim-3+ natural killer {NK)T cells are in an activated state, and Gal-9 directly induces Tim-3+ NKT cell apoptosis and contributes to the depletion of NKT cells in diet-induced steatosis. PMID: 23296703
48. T-cell Ig mucin-3 (Tim-3) and its ligand, galectin 9 (Gal-9), were significantly decreased in dextran sodium sulfate-induced colitis PMID: 23117395
49. Deletion of the terminal cytoplasmic domain of Tim3 potentiates its ability to downregulate cytotoxic lymphocytes (Tc1) inflammation; this enhanced Tim3 activity is associated with decreased phosphorylation of the T cell receptor-CD3zeta-chain. PMID: 22875804
50. TIM-3 circumvents the stimulatory effects of nucleic acids in tumor immunity by interactding with HMGB1 to interfere with the recruitment of nucleic acids into dendritic cell endosomes PMID: 22842346
51. These studies are the first to show that the absence of Tim-3/gal-9 pathway interactions augments systemic graft versus host disease and regulatory T-cells contributute to it. PMID: 22677125
52. the number and frequencey of FoxP3, TIM-3, PD-1 expressing Treg cells, present during allograft response, peaks at the time of graft rejection. PMID: 22684103
53. Soluble Gal-9 interacts with Tim-3 expressed on the surface of activated CD4(+) T cells. This leads to down-regulation of HIV-1 coreceptors and up-regulation of the cyclin-dependent kinase inhibitor p21. PMID: 22438246
54. Galectin-9 regulates T helper cell function independently of Tim-3 PMID: 21187321
55. The Tim-3 and PD-L1-mediated signaling can significantly reduce pathologies in the upper genital tract without suppressing immunity against chlamydial infection. PMID: 22168579
56. Tim-3 expression was increased in Helicobacter pylori infection. PMID: 21923683
57. augmented expression of Tim-3 may play an important role in the pathogenesis of ischemic stroke by regulation of proinflammatory cytokines. PMID: 21519864
58. host homeostatic mechanism mediated by Gal-9/Tim-3 interaction on CD8(+) T cells can influence the outcome of HSV-1 latent infection. PMID: 22021615
59. we identified a unique phenotype of exhausted T cells in mice with advanced acute myelogenous leukemia; this phenotype is characterized by the coexpression of Tim-3 and PD-1 on CD8(+) T cells in the liver PMID: 21385853
60. Galectin-9 and Tim-3 are closely related to inflammatory process in asthma. PMID: 21575348
61. TIM-3-TLR4 cross-regulation determined the severity of liver ischemia reperfusion injury in TLR4-dependent manner PMID: 20637206
62. Tim3 is up-regulated in kidneys in nephrotoxic serum nephritis and Tim3 exerts protective roles in the course of disease PMID: 20167865
63. TIM-3 is a key regulatory molecule of alloimmunity through its ability to broadly modulate CD4(+) T cell differentiation PMID: 20956339
64. the T(H)1 cell surface molecule Tim3 has evolved to inhibit growth of intracellular pathogens via its ligand Gal9, which in turn inhibits expansion of effector T(H)1 cells to prevent further tissue inflammation. PMID: 20937702
65. Endothelial cell-expressed Tim-3 increases melanoms cell metastatic potential by facilitating tumor cell intravasation, survival in blood stream and extravasation. PMID: 20664975
66. Data show that targeting both PD-1 and Tim-3 is an effective immune strategy for treating chronic viral infections. PMID: 20679213
67. The mechanisms responsible for the outcome of the Gal-9/TIM-3 interaction in normal infected mice involved direct inhibitory effects on TIM-3(+) CD8(+) T effector cells as well as the promotion of Foxp3(+) regulatory T cell activity PMID: 20463811
68. Increased Tim-3 expression was detected in natural killer cells isolated from the liver of hepatitis B virus transgenic mice. PMID: 20133006
69. Tim-3 expression is regulated by the Th1-specific transcription factor T-bet PMID: 20049876
70. Mouse TIM-3 binds and phagocytoses apoptotic cells, with the BALB/c allelic variant of mouse TIM-3 showing a higher phagocytic capacity than the congenic (C.D2 Es-Hba)-allelic variant. PMID: 20083673
71. Our data suggest that the Tim-3 pathway is highly involved in the negative regulation of inflammatory bowel disease PMID: 19913460
72. flTim-3 but not sTim-3 may induce tumor immunological tolerance. PMID: 15989777
73. the Tim-3-galectin-9 pathway may have evolved to ensure effective termination of effector T helper type 1 cells PMID: 16286920
74. Soluble T cell Ig mucin 3 (Tim-3) is an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response. PMID: 16424168
75. Tim-3 signaling on cells of the innate immune system critically influences regulation of the adaptive immune response. PMID: 16709797
76. A transient upregulation of Tim-3 expression was observed in the early stage of ACAID, suggesting its possible involvement in the development of ACAID. PMID: 16766398
77. The interplay between multiple Tim-3-binding activities contributes to the regulated assembly of signaling complexes required for effective Th1-mediated immunity. PMID: 17363302
78. Tim-3 inhibits TLR4 expression on mast cells and macrophages, indicating that cross- regulation occurs between these two receptors. PMID: 17513715
79. Tim-3 function has a beneficial effect during pulmonary inflammation by skewing the Th2 response toward that of a Th1 type, suggesting an important role for Tim-3 in the regulation of allergic disease. PMID: 17517968
80. data show that Tim-3 is highly expressed by cells of the innate immune system and that its expression on antigen-presenting cells promotes the secretion of proinflammatory cytokines from monocytes and dendritic cells PMID: 18006747
81. Tim-3-Galectin-9 pathway plays an important role in the termination of productive Th1-immune response and could lead to developing novel therapies in transplant medicine. PMID: 18346632
82. Gal-9 potentiates CD8(+) T cell-mediated antitumor immunity via Gal-9-Tim-3 interactions between DCs and CD8(+) T cells. PMID: 19017954
83. a crucial role for Tim-3 in phagocytosis of apoptotic cells and cross-presentation, which may be linked to peripheral tolerance. PMID: 19224762
84. Interaction of Tim-3 with galectin-9 plays a critical role in influencing the expression of herpes simplex virus-induced ocular lesions. PMID: 19234217
85. Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. PMID: 19254478
86. Tim-3-Galectin-9 pathway involves the function of CD4(+)CD25(+) regulatory T cells PMID: 19362679
87. In a murine model of atopic asthma, the expression of Tim-3 is increased in CD4+ T-cells following airway challenge and likely affects asthma-induced inflammation by repressing the Th1-mediated immune response. PMID: 19905911

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KEGG: mmu:171285

STRING: 10090.ENSMUSP00000020668

UniGene: Mm.72168