HAVCR2

HAVCR2, full name is hepatitis a virus cellular receptor 2, is usually called T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). It is a protein encoded by the HAVCR2 gene in human. HAVCR2 is implicated in modulating innate and adaptive immune responses as an immune checkpoint. HAVCR2 is primarily activated by galectin-9. The engagement leads to stimulation of an influx of calcium to intracellular space and induction of programmed cell death, apoptosis. As a consequence, a suppression of Th1 and Th17 responses and induction of immune tolerance occurs. In addition to galectin-9, a couple other ligands have been identified, such as phospatidyl serine (PtdSer), High Mobility Group Protein 1 (HMGB1) and Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1).

HAVCR2 Antibodies

HAVCR2 Antibodies for Homo sapiens (Human)

HAVCR2 Antibodies for Human

HAVCR2 Proteins

HAVCR2 Proteins for Homo sapiens (Human)

HAVCR2 ELISA Kit

HAVCR2 ELISA Kit for Homo sapiens (Human)

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