HAVCR2, full name is hepatitis a virus cellular receptor 2, is usually called T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). It is a protein encoded by the HAVCR2 gene in human. HAVCR2 is implicated in modulating innate and adaptive immune responses as an immune checkpoint. HAVCR2 is primarily activated by galectin-9. The engagement leads to stimulation of an influx of calcium to intracellular space and induction of programmed cell death, apoptosis. As a consequence, a suppression of Th1 and Th17 responses and induction of immune tolerance occurs. In addition to galectin-9, a couple other ligands have been identified, such as phospatidyl serine (PtdSer), High Mobility Group Protein 1 (HMGB1) and Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1).

HAVCR2 Antibodies

HAVCR2 Antibodies for Homo sapiens (Human)

HAVCR2 Proteins

HAVCR2 Proteins for Rattus norvegicus (Rat)

HAVCR2 Proteins for Homo sapiens (Human)

HAVCR2 Proteins for Mus musculus (Mouse)


HAVCR2 ELISA Kit for Homo sapiens (Human)


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