Recombinant Human Interleukin-17A & Interleukin-17F(IL17A & IL17F) (Active)

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Code CSB-AP004701HU
Product Type Interleukin
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Uniprot No. Q16552
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Storage Buffer Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.4
Alias IL?17A/F Heterodimer;IL-17A&IL-17F Heterodimer
Species Homo sapiens (Human)
Biological_Activity The ED50 as determined by its ability to induce IL-6 secretion by NIH?3T3 mouse embryonic fibroblast cells is typically 0.2 ng/mL.
Purity Greater than 90% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence GITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA & RKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTP VIHHVQ
Research Area Immunology
Source Mammalian cell
Gene Names IL17A & IL17F
Expression Region 24-155aa & 31-163aa
Tag Info C-terminal 6xHis-tagged
Mol. Weight 43.2 kDa
Protein Description Heterodimer
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Function Ligand for IL17RA and IL17RC
Subcellular Location Secreted
Protein Families IL-17 family
Tissue Specificity Restricted to activated memory T-cells.
Database Links

HGNC: 5981

OMIM: 603149

KEGG: hsa:3605

STRING: 9606.ENSP00000344192

UniGene: Hs.41724

Pathway IL-17 signaling pathway
Th17 cell differentiation

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