IL17A, interleukin 17A, alias CTLA8, is mainly produced by activated T cells, especially Th17 cells, and IL-17A is also produced by CD8+ T cells, γδ T cells, natural killer T cells (NKT), monocytes and neutrophils.
The mechanism of action of IL-17A involves binding to the IL-17 receptor family, particularly to IL-17RA with high affinity, activating downstream signaling pathways and promoting the production of inflammatory factors.
IL-17A plays a key role in host defense against a wide range of bacterial and fungal pathogens and is also involved in allergic and autoimmune responses. It induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases, which are involved in inflammatory and tissue repair processes and have been associated with the development of several autoimmune diseases and tumors.
Recombinant Human Interleukin-17A (IL17A) (T26A) (Active) (CSB-BP624104HU(M))
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IL17A at 2 μg/ml can bind Anti-IL17A recombinant antibody (CSB-RA624104MA1HU), the EC50 is 1.818-2.170 ng/mL.
IL17A Recombinant Monoclonal Antibody (CSB-RA624104MA1HU)
Validated Data
The Binding Activity of IL17A with anti-IL17A antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL17A(CSB-BP624104HU(M)) at 2 μg/ml can bind Anti-IL17A recombinant antibody, the EC50 is 1.818-2.170 ng/mL.
The following IL17A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IL17A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011597GA01HU | IL17A Antibody | Human | ELISA,IHC |
CSB-PA06659A0Rb | IL17A Antibody | Human | ELISA, IHC, IF |
CSB-PA06659B0Rb | IL17A Antibody, HRP conjugated | Human | ELISA |
CSB-PA06659C0Rb | IL17A Antibody, FITC conjugated | Human | |
CSB-PA06659D0Rb | IL17A Antibody, Biotin conjugated | Human | ELISA |
CSB-RA624104MA1HU | IL17A Recombinant Monoclonal Antibody | Human | ELISA |
IL17A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP624104HU CSB-EP624104HU CSB-BP624104HU CSB-MP624104HU CSB-EP624104HU-B |
Recombinant Human Interleukin-17A (IL17A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP001851HU | Recombinant Human Interleukin-17A protein (IL17A) | E.Coli |
CSB-AP004331HU | Recombinant Human Interleukin-17A (IL17A) (Active) | E.coli |
CSB-AP004341HU | Recombinant Human Interleukin-17A (IL17A) (Active) | Mammalian cell |
CSB-AP004701HU | Recombinant Human IL17A & IL17F Heterodimer Protein (Active) | Mammalian cell |
CSB-EP624104HU1 | Recombinant Human Interleukin-17A (IL17A), partial | E.coli |
CSB-BP624104HU(M) | Recombinant Human Interleukin-17A (IL17A) (T26A) (Active) | Baculovirus |
IL17A Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP717213RA CSB-BP717213RA CSB-MP717213RA CSB-EP717213RA-B |
Recombinant Rat Interleukin-17A (Il17a) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL17A Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP720298MO CSB-EP720298MO CSB-BP720298MO CSB-MP720298MO CSB-EP720298MO-B |
Recombinant Mouse Interleukin-17A (Il17a) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP004781MO | Recombinant Mouse Interleukin-17A (Il17a), partial (Active) | Mammalian cell |
IL17A Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP724243BO CSB-BP724243BO CSB-MP724243BO CSB-EP724243BO-B |
Recombinant Bovine Interleukin-17A (IL17A) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL17A Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP736792PI CSB-BP736792PI CSB-MP736792PI CSB-EP736792PI-B |
Recombinant Pig Interleukin-17A (IL17A) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL17A ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04608m | Mouse Interleukin 17,IL-17 ELISA Kit | serum, plasma, tissue homogenates | 19.5 pg/ml |
IL17A ELISA Kit for Sus scrofa (Pig)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E08057p | Pig interleukin 17,IL-17 ELISA Kit | serum, plasma, tissue homogenates | 10 pg/mL |
IL17A ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07451r | Rat Interleukin 17,IL-17 ELISA KIT | serum, plasma, tissue homogenates | 23.43 pg/mL |
IL17A ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E12819h | Human Interleukin 17A (IL-17A/IL-17) ELISA Kit | serum, plasma, tissue homogenates | 15.6 pg/ml |
CSB-E12819h-IS | Human Interleukin 17A (IL-17A/IL-17) ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/ml |