IL17A

Interleukin-17A is a protein in humans that is encoded by IL17A gene. Ligand for IL17RA and IL17RC.

The IL17 family is a class of pro-inflammatory cytokines secreted by CD4+T cells, and it consists of six members, including IL17A. ILU17A is located on chromosome 6p12.2 and transmits the signal by Il17R. It can induce the expression of a variety of inflammatory factors, mediate the inflammatory response and accelerate body repair to play a protective role. In chronic inflammation, IL17A continuously promotes the release of cytokines, chemokines, matrix metalloproteinases, and others as well as immune cell infiltration by activating NF-ҠB, JAK/STAT, and other signaling pathways, thereby promoting the occurrence and development of the disease. In addition, IL17A can also promote the secretion of a variety of angiogenic regulatory factors, and promote the formation and metastasis of tumor blood vessels.

More Interesting read related IL17A: A Major Cytokine of the IL-17 Family, a Key Inflammation Target in Skin Diseases, or Inflammation-Associated Cancers!

Popular Product

Recombinant Human Interleukin-17A(IL17A)(T26A) (Active) CSB-BP624104HU(M)

Validated Data

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA Blot

Measured by its binding ability in a functional ELISA. Immobilized Human IL17A at 2 μg/ml can bind Anti-IL17A recombinant antibody (CSB-RA624104MA1HU), the EC₅₀ is 1.818-2.170 ng/mL.