| Gene References into Functions |
- Injection of IL-21-expressing or IL-33-expressing plasmids facilitates clearance of pre-established genotype B strain designated BPS (BPS) persistence and protects cured mice from BPS re-challenge. PMID:
29242561
- this study shows that IL4 and IL21 cooperate to induce the high Bcl6 protein level required for germinal center formation PMID:
28875978
- This finding warrants future development of IL-21 and IL-7 co-expressing whole-cell cancer vaccines and their relevant combinatorial regimens. PMID:
27571893
- The studies link IL-21 to T cell ontogeny, self-reactivity, and humoral autoimmunity. PMID:
28978474
- IL-21 signaling has a critical role in optimal host resistance against Mycobacterium tuberculosis infection PMID:
27819295
- memory-like NK cells expansion depends on IL-21, and is involved in vaccine-induced protective immunity against a bacterial pathogen PMID:
27924822
- IL-6 is identified as a master regulator of IL-21 in effector CD8(+) T cells. PMID:
27670591
- Our work suggests that IL-21 regulates megakaryocyte development and platelet homeostasis. Thus, IL-21 may link immune responses to physiological or pathological platelet-dependent processes. PMID:
28057742
- we identify novel distal regulatory elements in the mouse Il21 locus and demonstrate a dynamic long-range chromatin interaction between the Il21 promoter and these regulatory elements, which contributes to the regulated expression of IL-21 PMID:
27067007
- this study shows that IL-21 acts as a potent inhibitor of a IL-17A-producing T-cell subset during Mycobacterium bovis Bacillus infection PMID:
27554052
- this study shows that combination of mIL-21 with HIV-1 vaccines leads to distinct enhancement of NK cells and T cell immune responses associated with immune protection PMID:
27062692
- The data of this study suggested that an increase in astrocyte-derived IL-21 expression in hippocampal subregions following KA-induced seizures may have potent regulatory effects on epileptogenesis. PMID:
27118610
- this study reveals a context-dependent role for IL-21 in sustaining effector phenotype CD8 T cells and influencing their migratory properties, accumulation, and functions. PMID:
26826252
- Dysregulated development of IL-17- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat. PMID:
26499265
- results demonstrate that, in the setting of lupus-like CD4 T cell-driven B cell hyperactivity, IL-21 signaling on Ag-specific donor CD8 T cells is critical for CTL effector maturation whereas a lack of IL-21R downregulates CTL responses that would otherwise limit B cell hyperactivity and autoantibody production PMID:
26792801
- IL-21 from microbiota-specific Th17 and/or Tfh cells contributes to robust intestinal IgA levels by enhancing IgA(+) CSR, IgA production and B-cell trafficking into the intestine. PMID:
25586558
- this report demonstrates a critical role for IL-21 in the generation of a primary effector CD8 T cell response to an infectious disease model. PMID:
26597007
- IL-21 drives the activation and expansion of a novel population of IL-13-producing Tc2 cells, which serve as a critical link between inflammation and fibrosis. PMID:
26519529
- these findings underscore the important collaboration between IL-4 and IL-21 in shaping T-dependent B cells antibody responses. PMID:
26491200
- IL-21-mediated signaling supports generation and stabilization of pathogenic Th17 cells and development of spontaneous autoimmunity. PMID:
26413871
- In vivo treatment with IL-21 results in complete mantle cell lymphoma regression in syngeneic mice via natural killer - and T-cell-dependent mechanisms. PMID:
26194763
- genetic deficiency results in reduced Th2 type response during allergic airway inflammation PMID:
26287681
- Data indicate that interleukin 21 knockout (il-21-/-) mice showed significantly diminished T follicular helper cell (TFH) generation/accumulation compared to wild type mice. PMID:
25251568
- The results indirectly provide evidence that IL-21 produced by CD4(+) T cells could promote Th1/Tc1 response, leading to systemic inflammation in emphysema. PMID:
24357415
- IL-21 suppresses the development of Th2 cells and functions of polarized Th2 cells. PMID:
25351608
- Inflammation and lymphopenia trigger autoimmunity by suppression of IL-2-controlled regulatory T cell and increase of IL-21-mediated effector T cell expansion. PMID:
25339665
- IL-21 blockage decreases BAFF levels, modulates T-cell function in acute GVHD, attenuates GVHD by inhibiting mTORC, and modulates B-cell homeostasis. PMID:
25246268
- In comparison with the DC-hgp100 or mIL-21 groups, the combinational DC-hgp100/mIL-21 vaccine drastically suppressed the myeloid-derived suppressor cells (MDSCs) and T-regulatory (Treg) cell populations. PMID:
24572790
- Data suggest that IL-21 exerts negative regulation on IRF4 and Treg activity, developing and maintaining adipose tissue inflammation in the obesity state. PMID:
24430438
- Under IL-2 deprivation conditions, IL-21 may act as the major survival factor promoting T cell immune responses. PMID:
24416451
- GM-SCF, IL-21 and Rae1 expression, alone or in combination, induces a cellular immune response against H22 tumor cells. PMID:
24350772
- IL-21 is highly up-regulated in the injured mouse brain after cerebral ischemia. PMID:
24616379
- Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression. PMID:
24550509
- CD86 expression has functional consequences for the magnitude of CD4 T cell responses both in vitro and in vivo. These data pinpoint CD86 upregulation as an additional mechanism by which IL-21 can elicit immunomodulatory effects. PMID:
24470500
- interleukin-21 enhances rituximab activity PMID:
23825648
- results indicate that besides IL-21, IL-21iso may be another regulator of gut inflammation PMID:
23557800
- IL-21 signaling to B cells is essential for the development of all classical disease manifestations, but IL-21 signaling also supports the expansion of central memory, CD8(+) suppressor cells and broadly represses the cytokine activity of CD4(+) T cells. PMID:
24078696
- IL-21 may also indirectly promote CD8+ T cell poly-functionality by restricting the suppressive activity of infection-induced Treg cells. PMID:
23696736
- a key role for IL-21 in shaping the humoral and cellular response to T. gondii PMID:
23667536
- IL-21 plays a critical role in regulating central nervous system immunity during viral encephalitis by sustaining viral persistence and preventing mortality. PMID:
23992866
- REsults suggest IL-21 is not required for follicular helper t-cell differentiation and function and IL-21 must act on B cells PMID:
23960240
- Notably, Th17 differentiation in the absence of NR4A2 was restored by exogenous IL-21, indicating that NR4A2 controls full maturation of Th17 cells via autocrine IL-21 signalling PMID:
23437182
- required for induction of type I diabetes PMID:
23607664
- These preliminary data show that IL-21 is critical for the development of optimal vaccine-induced primary but not secondary antibody responses against rabies virus infections. PMID:
23516660
- Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells. PMID:
23637417
- Secreted IL-21 isoform also has less signaling activity than IL-21. PMID:
23312859
- IL-21 mRNA is reduced in the spleens of lyn(-/-) IL-6(-/-) and lyn(-/-) Btk(lo) mice. PMID:
23169140
- Together, these results showed for the first time that IL-21 influences the biology and the effector activity of Natural killer dendritic cells. PMID:
23098768
- Local suppression of IL-21 alleviated secretory disfunction and disrupted lymphocyte infiltration in submandibular glands of NOD mice and thus retarded the development of Sjorgren's-like symptoms of NOD mice. Tfh cells were also inhibited. PMID:
22643047
- Results indicate a reciprocal production of IL-21 and GM-CSF in T4 cells. PMID:
23453633
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