Recombinant Mouse Interleukin-21 protein(Il21) (Active)

In Stock
Code CSB-AP003391MO
Product Type Interleukin
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q9ES17
Lead Time 5-10 business days
Image
Storage Buffer 0.2 m filtered 2 x PBS, pH 7.4 ,lyophilized
Alias IL-21
Species Mus musculus (Mouse)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human N1186 T cells is less than 25 ng/ml, corresponding to a specific activity of >4.0x104 IU/mg.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence HKSSPQGPDR LLIRLRHLID IVEQLKIYEN DLDPELLSAP QDVKGHCEHA AFACFQKAKL KPSNPGNNKT FIIDLVAQLR RRLPARRGGK KQKHIAKCPS CDSYEKRTPK EFLERLKWLL QKMIHQHLS
Research Area Immunology
Source E.coli
Gene Names Il21
Expression Region 18-146aa
Tag Info Tag-Free
Mol. Weight 15.0 kDa
Protein Description Full Length of Mature Protein
PubMed ID 11081504; 11970879; 12893770; 15100251
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Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Subcellular Location Secreted
Protein Families IL-15/IL-21 family
Database Links

KEGG: mmu:60505

STRING: 10090.ENSMUSP00000029273

UniGene: Mm.157689

Pathway Jak-STAT signaling pathway
Th17 cell differentiation

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