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| Code | CSB-AP003391MO |
| Product Type | Interleukin |
| Size |
US$112Purchase it in Cusabio online store (Shop online in the US. Customers outside the US, please order from local distributors.) |
| Uniprot No. | Q9ES17 |
| Lead Time | 5-10 business days |
| Image | |
| Storage Buffer | 0.2 m filtered 2 x PBS, pH 7.4 ,lyophilized |
| Alias | IL-21 |
| Species | Mus musculus (Mouse) |
| Biological_Activity | Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human N1186 T cells is less than 25 ng/ml, corresponding to a specific activity of >4.0x104 IU/mg. |
| Purity | >98% as determined by SDS-PAGE and HPLC. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Sequence | HKSSPQGPDR LLIRLRHLID IVEQLKIYEN DLDPELLSAP QDVKGHCEHA AFACFQKAKL KPSNPGNNKT FIIDLVAQLR RRLPARRGGK KQKHIAKCPS CDSYEKRTPK EFLERLKWLL QKMIHQHLS |
| Research Area | Immunology |
| Source | E.coli |
| Gene Names | Il21 |
| Expression Region | 18-146aa |
| Tag Info | Tag-Free |
| Mol. Weight | 15.0 kDa |
| Protein Description | Full Length of Mature Protein |
| PubMed ID | 11081504; 11970879; 12893770; 15100251 |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. |
| Subcellular Location | Secreted |
| Protein Families | IL-15/IL-21 family |
| Database Links |
KEGG: mmu:60505 STRING: 10090.ENSMUSP00000029273 UniGene: Mm.157689 |
| Pathway |
Jak-STAT signaling pathway
Th17 cell differentiation |
Il21 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP887666MO CSB-EP887666MO CSB-BP887666MO CSB-MP887666MO |
Recombinant Mouse Interleukin-21(Il21) | Yeast E.coli Baculovirus Mammalian cell |
Il21 ELISA Kit for Mus musculus (Mouse)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E13162m | Mouse Interleukin 21(IL-21) ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/mL |
Recombinant Human Multidrug resistance-associated protein 1 (ABCC1),partial
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Integrin alpha-2(ITGA2) ,partial
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Macaca mulatta Interleukin-10(IL10)
Express system: Yeast
Species: Macaca mulatta (Rhesus macaque)
Recombinant Pig Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial(ETFDH)
Express system: E.coli
Species: Sus scrofa (Pig)
Recombinant Human Toll/interleukin-1 receptor domain-containing adapter protein(TIRAP)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Ras-related protein Rab-10(Rab10)
Express system: E.coli
Species: Mus musculus (Mouse)
