Recombinant Macaca mulatta Cytokine receptor common subunit gamma (IL2RG), partial (Active)

The common gamma chain (γc) is shared by receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, making it a central node in cytokine signaling networks that govern T cell development, NK cell function, and immune homeostasis. This recombinant rhesus macaque IL2RG, spanning the extracellular domain (aa 23–255) and expressed in mammalian cells to preserve native glycosylation and disulfide architecture, demonstrates quantifiable binding to an anti-IL2RG antibody with an EC50 of 33.73–41.04 ng/mL in functional ELISA, confirming conformational integrity suitable for ligand-receptor interaction studies and therapeutic antibody epitope mapping. The protein meets the purity and endotoxin criteria typical for competitive inhibition assays, blocking antibody screening, and SPR-based affinity characterization in cytokine receptor research, with >95% purity by SDS-PAGE and <1.0 EU/μg endotoxin. Researchers investigating primate immunology or translating findings from macaque models can use this reagent as a positive control in binding assays or for validating biologics targeting the γc-dependent cytokine axis.