IL2RG

IL2RG, also known as the interleukin-2 receptor γ chain, is alternatively referred to as CD132. IL2RG is a component of multiple cytokine receptors, including those for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, collectively known as receptor common γ chains. IL2RG forms heterodimers with specific transmembrane subunits, activating Janus kinases JAK1 and JAK3, thereby transmitting cytokine signals. IL2RG is crucial for the development and function of lymphocytes; mutations in its gene can lead to X-linked severe combined immunodeficiency (XSCID), characterized by a significant decrease in T-cell and NK-cell counts, as well as abnormal B-cell function.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IL2RG at 2 μg/ml can bind Anti-IL2RG recombinant antibody (CSB-RA011651MA1HU). The EC₅₀ is 12.19-13.63 ng/mL.

IL2RG Antibody (CSB-PA011651EA01HU)

Validated Data

Western blot
All lanes: IL2RG antibody at 12µg/ml
Lane 1: Jurkat whole cell lysate
Lane 2: K562 whole cell lysate
Lane 3: HL60 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 43, 21 kDa
Observed band size: 43 kDa

Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA011651EA01HU at dilution of 1:100

Human Cytokine receptor common subunit gamma(IL2RG) ELISA kit (CSB-EL011651HU)

Validated Data

Code: CSB-EL011651HU

Size: 96T,5×96T,10×96T

Sensitivity: 0.078 ng/mL

Detection Range: 0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following IL2RG reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

IL2RG Antibodies

IL2RG Proteins

IL2RG ELISA Kits

IL2RG Antibodies

IL2RG Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA011651GA01HU	IL2RG Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA011651EA01HU	IL2RG Antibody	Human	ELISA, WB, IHC
CSB-PA011651EB01HU	IL2RG Antibody, HRP conjugated	Human	ELISA
CSB-PA011651EC01HU	IL2RG Antibody, FITC conjugated	Human
CSB-PA011651ED01HU	IL2RG Antibody, Biotin conjugated	Human	ELISA
CSB-PA005615	IL2RG Antibody	Human	WB, ELISA
CSB-PA927147	IL2RG Antibody	Human	ELISA,IHC
CSB-PA082388	IL2RG Antibody	Human	ELISA,IHC

IL2RG Proteins

IL2RG Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP836046BO CSB-EP836046BO CSB-BP836046BO CSB-MP836046BO CSB-EP836046BO-B	Recombinant Bovine Cytokine receptor common subunit gamma (IL2RG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL2RG Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF011651HU	Recombinant Human Cytokine receptor common subunit gamma (IL2RG)	in vitro E.coli expression system
CSB-YP011651HU1 CSB-EP011651HU1 CSB-BP011651HU1 CSB-MP011651HU1 CSB-EP011651HU1-B	Recombinant Human Cytokine receptor common subunit gamma (IL2RG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-BP011651HU3(M)	Recombinant Human Cytokine receptor common subunit gamma (IL2RG) (N75Q), partial	Baculovirus
CSB-EP011651HU3(M)	Recombinant Human Cytokine receptor common subunit gamma (IL2RG) (N75Q), partial	E.coli
CSB-MP011651HU4	Recombinant Human Cytokine receptor common subunit gamma(IL2RG),partial (Active)	Mammalian cell

IL2RG Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF011651MO	Recombinant Mouse Cytokine receptor common subunit gamma (Il2rg)	in vitro E.coli expression system
CSB-YP011651MO1 CSB-EP011651MO1 CSB-BP011651MO1 CSB-MP011651MO1 CSB-EP011651MO1-B	Recombinant Mouse Cytokine receptor common subunit gamma (Il2rg), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL2RG Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-CF011651DO	Recombinant Dog Cytokine receptor common subunit gamma (IL2RG)	in vitro E.coli expression system
CSB-YP011651DO1 CSB-EP011651DO1 CSB-BP011651DO1 CSB-MP011651DO1 CSB-EP011651DO1-B	Recombinant Dog Cytokine receptor common subunit gamma (IL2RG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL2RG ELISA Kit

IL2RG ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL011651HU	Human Cytokine receptor common subunit gamma(IL2RG) ELISA kit	serum, plasma, tissue homogenates	0.078 ng/mL

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IL2RG

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