Recombinant Mouse Leukemia inhibitory factor (Lif) (Active)

1. Inhibition of Lif protein in the hypothalamus transforms obesity-resistant mice into obesity-prone mice. PMID: 28865476
2. mouse embryonic stem cells inside microchambers formed colonies and expressed markers of pluripotency in the absence of feeders or pluripotency-inducing signals such as leukemia inhibitory factor. PMID: 26865369
3. lung epithelium, specifically alveolar type II cells, is the predominant site of LIF transcript induction in pneumonic mouse lungs. PMID: 28522567
4. LIF/STAT3 and MEK/ERK signaling in naive embryonic stem cell pluripotency, is reported. PMID: 27676194
5. LIF stimulates, in part, stem cell-derived cardiomyocyte regeneration by activating cardiac stem or precursor cells. PMID: 27227407
6. Our data show that absence of SOCS2 turns cardiomyocytes unresponsive to LIF-induced [Ca(2+)] raise, indicating that endogenous levels of SOCS2 are crucial for full activation of LIF signaling in the heart. PMID: 28122728
7. These results establish that Bcl3 positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 as a downstream molecule of LIF/STAT3 signaling in pluripotency maintenance. PMID: 26303070
8. The role of LIF in acetylcholine synthesis via the STAT3, PI3 kinases, or cAMP-protein kinase A pathways, are reported. PMID: 25887270
9. Either LIF or EGF is needed during development of pre-implantation embryo. PMID: 27096934
10. Our data suggest that LIF plays an important role in placentation in vivo and the maintenance of healthy pregnancy. PMID: 26272398
11. Despite common signal transduction mechanisms (JAK/STAT, MAPK and PI3K) LIF can have paradoxically opposite effects in different cell types including stimulating or inhibiting each of cell proliferation, differentiation and survival. PMID: 26187859
12. Mechanistically, LIF activates STAT, which binds to a Stat consensus sequence in the Six2 proximal promoter and sustains SIX2 levels. PMID: 26321142
13. These findings suggest that maternal IL-6 interferes the maternal-fetal LIF signal relay by inducing SOCS3 in the placenta and leads to decreased neurogenesis. PMID: 26043040
14. Studied the expression of heme oxygenase-1 (HO-1) and leukemia inhibitory factor (LIF) in maternal plasma and placental tissue in intrauterine infection-induced preterm birth. PMID: 26995887
15. LIF gene breakage was captured at the 18th hour after carbon disulfide exposure by Comet-FISH and the protein and mRNA of LIF in uterine tissue were down-regulated after carbon disulfide exposure through the peri-implantation period PMID: 26427868
16. LIF has a role in primitive endoderm expansion during pre-implantation development PMID: 26395492
17. Study shows that LIF-treated postmitotic oligodendrocytes secrete a number of neuropeptides at the mRNA and peptide level, and confirm LIF-induced galanin synthesis and secretion in primary rat oligodendrocytes but not in astrocytes PMID: 25639936
18. In a preclinical animal model of MS shifting the LIF/IL-6 balance in favor of LIF by CNS-targeted overexpression increased the number of Tregs in the CNS during active autoimmune responses and reduced disease symptoms. PMID: 25514345
19. LIF and miR-302 family positively affect the expression of pluripotency markers. PMID: 25147827
20. these results reveal a novel function of miR-181 in embryo implantation through the regulation of LIF, and also indicate a potential link between miR-181 dysregulation and human embryo implantation defects. PMID: 25635127
21. Expression of LIF protects the lung from lung injury and enhanced pathology during respiratory syncytial virus infection. PMID: 25277705
22. Data suggest LIF induces dynamic/complex network of changes in endometrium, changes that appear essential to reproduction; changes involve gene expression regulation for cytoskeletal proteins and proteins involved in chromatin assembly/disassembly. PMID: 25031358
23. The difference in the balance between the JAK-Stat3 pathway and the MAP kinase pathway underlies the differential response to LIF amongst mice strains. PMID: 25564647
24. Data show that the contribution of leukemia inhibitory factor (LIF) for embryo implantation was dependent on the strains of mice. PMID: 24698551
25. an essential function of Foxm1 in the LIF/Stat3-mediated mESC self-renewal and the generation of iPSCs PMID: 24743237
26. LIF suppresses osteoblast differentiation through the LIF/STAT3/SOCS3 signaling pathway. PMID: 24464633
27. Results show that endogenous levels of Pkig reciprocally regulate osteoblast and adipocyte differentiation and that this reciprocal regulation is mediated in part by LIF. PMID: 23963683
28. study presents for the first time that estrogen regulates Egr1 expression through LIF-STAT3 signaling pathway in mouse uterus, and Egr1 functions as a critical mediator of stromal cell decidualization by regulating Wnt4 PMID: 25012664
29. Addition of leukemia inhibitory factor (LIF) neutralizing antibodies inhibited oligodendrocyte differentiation, indicating a crucial role of TNFR2-induced astrocyte derived LIF for oligodendrocyte maturation PMID: 24310780
30. Uterine kisspeptin signaling regulates glandular Lif levels, regulating embryo implantation PMID: 24877624
31. This mini review will summarize the findings that are related to LIF signaling and discuss the neuroprotective effects of LIF in different animal models. PMID: 24664722
32. Induced pluripotent stem cells-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of LIF. PMID: 24169527
33. Expression of Lif in the injured retina and activation of the endogenous survival pathway involve signaling through p38 MAPK. PMID: 24008729
34. Tfcp2l1 is the principal bridge between LIF/Stat3 input and the transcription factor core of naive pluripotency. PMID: 23942233
35. A pivotal role of PPARgamma on mouse embryonic stem cell self-renewal depends on the presence and absence of LIF. PMID: 23628590
36. LIF was able to modulate the levels of nitric oxide induced by LPS in vitro, suggesting that it could be a potential mediator of the inflammatory action of progesterone PMID: 23409146
37. These studies demonstrate that endogenous CNTF and LIF act centrally to protect axons from acute inflammatory destruction via an oligodendrocyte-independent mechanism. PMID: 23077604
38. we show that LIF increases the expression of the core transcription factors PMID: 23258129
39. The rapid release of leukemia inhibitory factor from cortical neurons protects them against excitotoxicity. PMID: 22894638
40. Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes, showing that STAT3 signaling is redox-sensitive PMID: 22905257
41. These results provide further evidence for the role of LIF in inflammation and cartilage bone resorption and provide impetus to test the effects of LIF blockade as a therapeutic strategy in rheumatoid arthritis. PMID: 22774981
42. The LIF-STAT3 axis is identified in this study as a critical determinant of lung injury with clinical implications for pneumonia patients. PMID: 22581855
43. LIF controls vascular size and osteoclast differentiation during the transition of cartilage to bone, whereas an anatomically separate LIF-dependent pathway regulates osteoblast and adipocyte commitment in bone remodeling PMID: 22143976
44. Aute short-term depletion of tet1 results in impairment of LIF-dependent Stat3-mediated gene activation. PMID: 22210859
45. LIF expression might be regulated by microRNA-199a PMID: 22285730
46. Liver sinusoidal endothelial cells constitutively express LIF at the mRNA and protein level. PMID: 21930391
47. Study demonstrated that LIF was an important regulator of decidualization in humans and mice. PMID: 21966484
48. Extensive mannose phosphorylation on leukemia inhibitory factor (LIF) controls its extracellular levels by multiple mechanisms. PMID: 21613225
49. Blockade of LIF signalling results in a 50% decrease in embryo implantation. PMID: 19635738
50. LIF removal results in the rapid phosphorylation of multiple proteins regulating murine embryonic stem cell self-renewal on Tyr, Ser, & Thr residues. These posttranslational modifications help drive the exit of mESCs from the pluripotent state. PMID: 22074622

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KEGG: mmu:16878

STRING: 10090.ENSMUSP00000067066

UniGene: Mm.4964