AASS Antibody, FITC conjugated

Code CSB-PA883373LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) AASS Polyclonal antibody
Uniprot No.
Target Names
AASS
Alternative Names
AASSAlpha-aminoadipic semialdehyde synthase antibody; mitochondrial antibody; LKR/SDH) [Includes: Lysine ketoglutarate reductase antibody; LKR antibody; LOR antibody; EC 1.5.1.8); Saccharopine dehydrogenase antibody; SDH antibody; EC 1.5.1.9)] antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Alpha-aminoadipic semialdehyde synthase, mitochondrial protein (224-364AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
Gene References into Functions
  1. GR and KLF15 physically interact via low affinity GR binding sites within glucocorticoid response elements (GREs) for PRODH and AASS that contribute to combinatorial regulation with KLF15. PMID: 26088140
  2. Mitochondrial NADPH is crucial for AASS function PMID: 24847004
  3. Hyperlysinemia is caused by mutations in AASS PMID: 23570448
  4. Isolation and characterization of the mouse ortholog. PMID: 10567240
Involvement in disease
Hyperlysinemia, 1 (HYPLYS1); 2,4-dienoyl-CoA reductase deficiency (DECRD)
Subcellular Location
Mitochondrion.
Protein Families
AlaDH/PNT family; Saccharopine dehydrogenase family
Tissue Specificity
Expressed in all 16 tissues examined with highest expression in the liver.
Database Links

HGNC: 17366

OMIM: 238700

KEGG: hsa:10157

STRING: 9606.ENSP00000377040

UniGene: Hs.156738

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