AASS Antibody

Datasheet
Code CSB-PA883373LA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. Q9UDR5
Image
  • Western Blot
    Positive WB detected in: Hela whole cell lysate, 293T whole cell lysate, HepG2 whole cell lysate
    All lanes: AASS antibody at 5.8µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 103 kDa
    Observed band size: 103 kDa

  • IHC image of CSB-PA883373LA01HU diluted at 1:400 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA883373LA01HU diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human Alpha-aminoadipic semialdehyde synthase, mitochondrial protein (224-364AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500
Relevance Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)], AASS
Immunogen Species Human
Research Area Signal Transduction
Target Names AASS
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
Involvement in disease Hyperlysinemia, 1 (HYPLYS1); 2,4-dienoyl-CoA reductase deficiency (DECRD)
Subcellular Location Mitochondrion
Protein Families AlaDH/PNT family; Saccharopine dehydrogenase family
Tissue Specificity Expressed in all 16 tissues examined with highest expression in the liver.
Database Links

HGNC: 17366

OMIM: 238700

KEGG: hsa:10157

STRING: 9606.ENSP00000377040

UniGene: Hs.156738

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