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| Code | CSB-PA001032GA01HU |
| Product Type | Purified Rabbit Anti human PolyClonal Antibody |
| Size | US$685 |
| Uniprot No. | P80404 |
| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
| Immunogen | Human ABAT |
| Raised in | Rabbit |
| Species Reactivity | Human,Mouse,Rat |
| Tested Applications | ELISA,WB,IHC |
| Storage Buffer | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method | Antigen Affinity Purified |
| Isotype | IgG |
| Alias | 4-aminobutyrate aminotransferase;ABAT;FLJ17813;GABA-AT;GABAT;NPD009 ; |
| Immunogen Species | Homo sapiens (Human) |
| Target Names | ABAT |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Target Details | 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. |
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| Function | Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. |
| Involvement in disease | GABA transaminase deficiency (GABATD) |
| Subcellular Location | Mitochondrion matrix |
| Protein Families | Class-III pyridoxal-phosphate-dependent aminotransferase family |
| Tissue Specificity | Liver > pancreas > brain > kidney > heart > placenta. |
| Database Links |
HGNC: 23 OMIM: 137150 KEGG: hsa:18 STRING: 9606.ENSP00000268251 UniGene: Hs.336768 |
ABAT Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA001032ESR1HU | ABAT Antibody | Human, Mouse, Rat | ELISA, WB, IHC |
ABAT Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP001032HU CSB-BP001032HU CSB-MP001032HU |
Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial(ABAT) | Yeast Baculovirus Mammalian cell |
| CSB-EP001032HU | Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial(ABAT) | E.coli |
2-hydroxyisobutyryl-HIST1H3A (K23) Antibody
Applications: ELISA, WB, IF, ChIP
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H3A (K27) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H3A (K4) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
