ABAT

The ABAT gene encodes 4-aminobutyric acid aminotransferase (GABA-T), an enzyme also known as gamma-aminobutyric acid transaminase. It catalyzes the transamination of GABA—the central nervous system’s primary inhibitory neurotransmitter—with alpha-ketoglutarate, producing succinic semialdehyde and glutamate to regulate GABA homeostasis in GABAergic signaling pathways.
Mutations in ABAT cause hereditary GABA transaminase deficiency, a rare neurometabolic disorder characterized by severe epilepsy, developmental delay, and hypotonia. Pharmacologically, GABA-T inhibitors like vigabatrin are approved for refractory epilepsy (e.g., infantile spasms) to boost synaptic GABA levels, though long-term use may risk visual field defects.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ABAT Recombinant Monoclonal Antibody (CSB-RA242969A0HU)

Validated Data

IHC image of CSB-RA242969A0HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

ABAT Antibody (CSB-PA001032ESR1HU)

Validated Data

Western blot
All lanes: 4-aminobutyrate aminotransferase, mitochondrial antibody at 10μg/ml
Lane 1: Rat liver tissue
Lane 2: Mouse pancreatic tissue
Lane 3: Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 56 kDa
Observed band size: 56 kDa

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA001032ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA001032ESR1HU at dilution of 1:100

The following ABAT reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ABAT Antibodies

ABAT Proteins

ABAT Antibodies

ABAT Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA001032GA01HU	ABAT Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA001032ESR1HU	ABAT Antibody	Human, Mouse, Rat	ELISA, WB, IHC
CSB-RA242969A0HU	ABAT Recombinant Monoclonal Antibody	Human	ELISA, IHC

ABAT Proteins

ABAT Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP001032HU CSB-BP001032HU CSB-MP001032HU CSB-EP001032HU-B	Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP001032HU	Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT)	E.coli
CSB-EP001032HUe0	Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT)	E.coli

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ABAT

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