ABCE1 Antibody

Datasheet
Code CSB-PA001076ESR2HU
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Uniprot No. P61221
Image
  • Western blot
    All lanes: ABCE1 antibody at 4μg/ml
    Lane 1: 293T whole cell lysate
    Lane 2: Hela whole cell lysate
    Lane 3: k562 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 67 kDa
    Observed band size: 67 kDa

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA001076ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001076ESR2HU at dilution of 1:100

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human ATP-binding cassette sub-family E member 1 protein (320-599AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200
Relevance Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias ATP-binding cassette sub-family E member 1 (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I), ABCE1, RLI RNASEL1 RNASELI RNS4I
Immunogen Species Human
Research Area Signal Transduction
Target Names ABCE1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Subcellular Location Cytoplasm, Mitochondrion
Protein Families ABC transporter superfamily, ABCE family
Database Links

HGNC: 69

OMIM: 601213

KEGG: hsa:6059

STRING: 9606.ENSP00000296577

UniGene: Hs.12013

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