ABCE1 Antibody

Code CSB-PA001076ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot
    All lanes: ABCE1 antibody at 4μg/ml
    Lane 1: 293T whole cell lysate
    Lane 2: Hela whole cell lysate
    Lane 3: k562 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 67 kDa
    Observed band size: 67 kDa

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA001076ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001076ESR2HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ABCE1 Polyclonal antibody
Uniprot No. P61221
Target Names ABCE1
Alternative Names 2' 5' oligoadenylate binding protein antibody; 2''-5''-oligoadenylate-binding protein antibody; 2'5' oligoadenylate binding protein antibody; ABC 38 antibody; ABC38 antibody; ABCE 1 antibody; ABCE1 antibody; ABCE1_HUMAN antibody; ATP binding cassette sub family E (OABP) member 1 antibody; ATP binding cassette sub family E member 1 antibody; ATP-binding cassette sub-family E member 1 antibody; HuHP 68 antibody; HuHP68 antibody; OABP antibody; Ribonuclease 4 inhibitor antibody; Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) inhibitor antibody; Ribonuclease L (2'5' oligoisoadenylate synthetase dependent) inhibitor antibody; Ribonuclease L inhibitor antibody; RLI antibody; RNase L inhibitor antibody; RNASEL1 antibody; RNASELI antibody; RNS 4I antibody; RNS4I antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human ATP-binding cassette sub-family E member 1 protein (320-599AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:200-1:1000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Gene References into Functions
  1. Induction of ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall in platelets, including for hemoglobin production during blood cell development. PMID: 27681415
  2. ABCE1 is involved in histone biosynthesis and DNA replication and therefore is essential for normal S phase progression. PMID: 26985706
  3. The present study reported on the effects of ABCE1 overexpression on lung adenocarcinoma cells in vitro, demonstrating its enhancing effect on cell proliferation and invasiveness with simultaneous downregulation of p27 protein expression. PMID: 27314749
  4. ABCE1 plays an essential role in the progression and metastasis of lung cancers and may represent a valuable therapeutic target for the management of lung tumor PMID: 26733164
  5. miR-299-3p promotes the sensibility of lung cancer to doxorubicin through suppression of ABCE1, at least partly. Therefore, the disordered decreased of miR-299-3p and resulting ABCE1 up-expression may contribute to chemoresistance of lung cancer PMID: 26617714
  6. Expression of the ABCE1-silencing gene, transfected by electrotransfer, could inhibit the proliferation, invasion, and migration of thyroid cancer cells. PMID: 26600528
  7. Downregulation of ABCE1 via siRNA affects the sensitivity of lung cancer cells against chemotherapeutic agents. PMID: 25744244
  8. ABCE1 is closely associated with cell proliferation, invasion and migration in esophageal cancer and silencing the ABCE1 gene by electroporation can significantly reduce the proliferation, invasion and migration capacity PMID: 25815591
  9. ABCE1 is able to suppress RNA silencing in Nicotiana benthamiana plants, in mammalian HEK293 cells and in the worm Caenorhabditis elegans. PMID: 25659154
  10. ABCE1 is closely connected with the pathogenesis and development of oral cancer, which acts through the cellular pathways of 2-5A/RNase L. PMID: 25337191
  11. ABCE1 is closely connected with the pathogenesis and development of esophageal carcinoma, which act through the cellular pathways of 2-5A/RNase L. PMID: 24551278
  12. Studies indicate a strong sequence conservation of ABC-type ATPase ABCE1 in eukaryotes and archaea. PMID: 23266104
  13. ABCE1 protein regulates a broad range of biological functions including viral infection, tumor cell proliferation, and antiapoptosis. (Review) PMID: 23008114
  14. Pulse chase experiments and immunoelectron microscopy shows that HIV-1 Gag associates transiently with ABCE1 during HIV-1 capsid assembly, including at the plasma membrane where assembly is completed. PMID: 17233757
  15. HIV-1, HIV-2, SIV mac239, and SIVagm Gag proteins form ABCE1-containing assembly intermediates during immature capsid formation, indicating that Gag proteins of these diverse retroviruses bind to ABCE1 despite the limited homology between these Gags. PMID: 14747530
  16. For binding of WT HIV-1 Gag to the cellular ATPase ABCE1, which facilitates HIV-1 capsid assembly, the basic residues in the nucleocapsid domain of Gag are required but the cysteine and histidine residues in the nucleocapsid domain are dispensable. PMID: 16275648
  17. During assembly of an immature HIV-1 capsid, HIV-1 Gag progresses through a pathway of sequential assembly intermediates that contain ABCE1, a cellular ATPase that was found to facilitate capsid formation. PMID: 11780123
  18. To form HIV-1 capsid assembly intermediates, HIV-1 Gag co-opts a complex found in infected and uninfected cells that contains the cellular ATPase ABCE1 and the RNA helicase DDX6, both of which facilitate HIV-1 capsid assembly. PMID: 22851315
  19. Report high expression level of ABCE1 mRNA and protein in human lung adenocarcinoma tissues and metastatic lymph nodes, which was also correlated with clinical stages. PMID: 22267055
  20. Pelota/Hbs1 induced dissociation of elongation complexes from ribosomes and release of peptidyl-tRNA, but only in the presence of ABCE1. PMID: 21448132
  21. Results suggest that ABCE1 plays an important role in the pathogenesis of human small cell lung cancer cell. PMID: 20372810
  22. NTP hydrolysis by ABCE1 is stimulated by posttermination complexes and is required for its ribosomal recycling activity. PMID: 20122402
  23. were able to confirm the excess of rare genetic variation among HIV-1-positive African-American individuals (n=53; Tajima's D=-2.34). These results highlight the potential importance of ABCE1's role in infectious diseases such as HIV-1. PMID: 19657357
  24. HIV-2 Gag associates with human HP68 in a cell-free system and that Gag proteins of HIV-2, simian immunodeficiency virus SIVmac239, and SIVagm associate with endogenous HP68 in primate cells, as is seen for HIV-1. PMID: 14747530
  25. overexpression in a permissive cell line had no significant effect on varicella zoster virus replication PMID: 15107989
  26. ABCE1 and its peptides could be target molecules in specific immunotherapy for HLA-A2(+) colon cancer patients. PMID: 15809757
  27. The primary role of ABCE-1 in the effect of TULA appears to be the recruitment of TULA to the sites of HIV-1 assembly where TULA interferes with the late steps of the HIV-1 life cycle. PMID: 18006034
  28. host protein essential for assembly of immature HIV-1 capsids PMID: 11780123

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Subcellular Location Cytoplasm, Mitochondrion
Protein Families ABC transporter superfamily, ABCE family
Database Links

HGNC: 69

OMIM: 601213

KEGG: hsa:6059

STRING: 9606.ENSP00000296577

UniGene: Hs.12013

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