ACAP1 Antibody

Code CSB-PA622985EA01HU
Size US$166
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Image
  • Western blot
    All lanes: ACAP1 antibody at 4µg/ml
    Lane 1: Mouse lung tissue
    Lane 2: Jurkat whole cell lysate
    Lane 3: K562 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 82 kDa
    Observed band size: 82 kDa

  • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA622985EA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA622985EA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ACAP1 Polyclonal antibody
Uniprot No.
Target Names
ACAP1
Alternative Names
ACAP 1 antibody; ACAP1 antibody; ACAP1_HUMAN antibody; Arf GAP with coiled coil ANK repeat and PH domains 1 antibody; Arf GAP with coiled coil; ankyrin repeat; and pleckstrin homology domains 1 antibody; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1 antibody; ArfGAP with coiled-coil; ankyrin repeat and PH domains 1 antibody; CENT B1 antibody; Centaurin beta 1 antibody; Centaurin-beta-1 antibody; CENTB 1 antibody; Cnt b1 antibody; Cnt-b1 antibody; Cntb1 antibody; KIAA0050 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 protein (1-266AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ACAP1 Antibody (Product code: CSB-PA622985EA01HU) is Non-conjugated. For ACAP1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA622985EB01HU ACAP1 Antibody, HRP conjugated ELISA
FITC CSB-PA622985EC01HU ACAP1 Antibody, FITC conjugated
Biotin CSB-PA622985ED01HU ACAP1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
Gene References into Functions
  1. The serum lever of Alzheimer's disease were decrease and the expression of ACAP1 strongly correlated with the Mini-Mental State Examination scores of the AD patients PMID: 25502766
  2. ACAP1 and ARAP2 each colocalize with Arf6 but they did not colocalize with each other and have opposing effects on focal adhesions. PMID: 25225293
  3. CENTB1 was up-regulated in patients with active UC as compared to UC remission and healthy control groups suggesting that it is involved in the inflammatory process. PMID: 23317930
  4. phosphorylation of ACAP1 relieves a localized mechanism of autoinhibition in regulating cargo binding PMID: 22645133
  5. the oncogenic potential of USP6 is linked to its ability to integrate cell migration and cytokinesis by regulating Arf6/ACAP1. PMID: 22188517
  6. ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. PMID: 15525538
  7. CENTB1 selectively down-regulates NF-kappaB activation via NODs pathways, creating a "feedback" loop and suggesting a novel role of CENTB1 in innate immune responses to bacteria and inflammatory responses PMID: 17005562
  8. Results suggest that two ARF6 downstream molecules, PIP5K and ACAP1, function together in endosomal tubulation and that phosphoinositide levels may regulate endosomal dynamics. PMID: 17010122
  9. Results suggest that ACAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6, is part of a novel clathrin coat complex that is regulated by ARF6 for endocytic recycling in two key physiological settings. PMID: 17664335
  10. ACAP1 has robust, constitutive Arf6 GAP activity in vivo, with little activity toward Arf1. PMID: 18003747
  11. Centaurin beta1/KIAA0050, is a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins. Binding of phosphoinositides to a pleckstrin homology domain may regulate subcellular localisation and activity. PMID: 11050434
  12. Centaurin beta1/KIAA0050, or ACAP1, is a phospholipid dependent, ARF6 preferring GTPase-activating protein. It can regulate cytoskeletal and membrane trafficking events in the cell periphery and may be regulated via a phosphoinositide-binding PH domain. PMID: 11062263

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Subcellular Location
Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Tissue Specificity
Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.
Database Links

HGNC: 16467

OMIM: 607763

KEGG: hsa:9744

STRING: 9606.ENSP00000158762

UniGene: Hs.337242

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