ACHE Antibody

Datasheet
Code CSB-PA904467
Size US$299
Uniprot No. P22303
Image
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: CSB-PA904467(ACHE Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Synthetic peptide of Human ACHE
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB;ELISA:1:1000-1:2000,WB:1:200-1:1000
Relevance Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias acetylcholinesterase
Immunogen Species Homo sapiens (Human)
Target Names ACHE
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Subcellular Location Cell junction, synapse, Secreted, Cell membrane, Peripheral membrane protein, SUBCELLULAR LOCATION: Isoform T: Nucleus
Protein Families Type-B carboxylesterase/lipase family
Tissue Specificity Isoform H is highly expressed in erythrocytes.
Database Links

HGNC: 108

OMIM: 100740

KEGG: hsa:43

STRING: 9606.ENSP00000303211

UniGene: Hs.154495

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