ACRBP Antibody

Code CSB-PA003609
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  • Western Blot analysis of HepG2 cells using OY-TES-1 Polyclonal Antibody
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Product Details

Uniprot No. Q8NEB7
Target Names ACRBP
Alternative Names ACRBP antibody; ACRBP_HUMAN antibody; acrosin binding protein antibody; Acrosin binding protein precursor antibody; Acrosin-binding protein antibody; Cancer/testis antigen 23 antibody; Cancer/testis antigen OY TES 1 antibody; Cancer/testis antigen OY-TES-1 antibody; CT23 antibody; FLJ51160 antibody; OY TES 1 antibody; Proacrosin binding protein sp32 antibody; Proacrosin-binding protein sp32 antibody; SP32 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthesized peptide derived from the Internal region of Human OY-TES-1.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.
Gene References into Functions
  1. Down regulation of OY-TES-1 increased expression of apoptosis-regulated protein caspase-3, and decreased expression of cell cycle-regulated protein cyclin E, migration/invasion-regulated proteins MMP2 and MMP9. PMID: 26339343
  2. OY-TES-1 downregulation in liver cancer cells caused 2 opposite effects on cell proliferation: promotion by upregulating CCND2 and CDCA3, and inhibition by CD9 upregulation and NANOG downregulation. OY-TES-1 may play multiple roles in liver cancer. PMID: 25673160
  3. OY-TES-1 was expressed in ovarian cancer (OC) tissues with a high proportion, and some of OC tissues presented OY-TES-1 expression in high level vs OC adjacent tissues. PMID: 26189257
  4. OY-TES-1 is frequently expressed in colorectal carcinoma and is able to induce humoral immune response spontaneously in CRC patients. PMID: 24294369
  5. The down-regulation of OY-TES-1 expression in bone marrow-derived mesenchymal stem cells caused cell growth inhibition, cell cycle arrest, apoptosis induction and migration ability attenuation. PMID: 22651134
  6. High ACRBP expression correlated with reduced survival time and faster relapse among ovarian cancer patients. PMID: 20876808
  7. We showed identification of HLA-A24-binding OY-TES-1 peptide, TES(401-409) (KTPFVSPLL) recognized by CD8 T-cells. PMID: 16301813

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Subcellular Location Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome.
Tissue Specificity Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers.
Database Links

HGNC: 17195

OMIM: 608352

KEGG: hsa:84519

STRING: 9606.ENSP00000229243

UniGene: Hs.123239

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