ACRBP Antibody

Datasheet

Code	CSB-PA003609
Size	US$119
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Image	Western Blot analysis of HepG2 cells using OY-TES-1 Polyclonal Antibody
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q8NEB7

Target Names

ACRBP

Alternative Names

ACRBP antibody; ACRBP_HUMAN antibody; acrosin binding protein antibody; Acrosin binding protein precursor antibody; Acrosin-binding protein antibody; Cancer/testis antigen 23 antibody; Cancer/testis antigen OY TES 1 antibody; Cancer/testis antigen OY-TES-1 antibody; CT23 antibody; FLJ51160 antibody; OY TES 1 antibody; Proacrosin binding protein sp32 antibody; Proacrosin-binding protein sp32 antibody; SP32 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the Internal region of Human OY-TES-1.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, IF, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:10000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.

Gene References into Functions

Down regulation of OY-TES-1 increased expression of apoptosis-regulated protein caspase-3, and decreased expression of cell cycle-regulated protein cyclin E, migration/invasion-regulated proteins MMP2 and MMP9. PMID: 26339343
OY-TES-1 downregulation in liver cancer cells caused 2 opposite effects on cell proliferation: promotion by upregulating CCND2 and CDCA3, and inhibition by CD9 upregulation and NANOG downregulation. OY-TES-1 may play multiple roles in liver cancer. PMID: 25673160
OY-TES-1 was expressed in ovarian cancer (OC) tissues with a high proportion, and some of OC tissues presented OY-TES-1 expression in high level vs OC adjacent tissues. PMID: 26189257
OY-TES-1 is frequently expressed in colorectal carcinoma and is able to induce humoral immune response spontaneously in CRC patients. PMID: 24294369
The down-regulation of OY-TES-1 expression in bone marrow-derived mesenchymal stem cells caused cell growth inhibition, cell cycle arrest, apoptosis induction and migration ability attenuation. PMID: 22651134
High ACRBP expression correlated with reduced survival time and faster relapse among ovarian cancer patients. PMID: 20876808
We showed identification of HLA-A24-binding OY-TES-1 peptide, TES(401-409) (KTPFVSPLL) recognized by CD8 T-cells. PMID: 16301813

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Subcellular Location

Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome.

Tissue Specificity

Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers.

Database Links

HGNC: 17195

OMIM: 608352

KEGG: hsa:84519

STRING: 9606.ENSP00000229243

UniGene: Hs.123239

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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