| Code | CSB-PA060488EA01HU |
| Size |
US$299Purchase it in Cusabio online store (only available for customers from the US) |
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| Full Product Name | Rabbit anti-Homo sapiens (Human) ACSL4 Polyclonal antibody | ||||||
| Uniprot No. | O60488 | ||||||
| Target Names | ACSL4 | ||||||
| Alternative Names | ACSL4; ACS4; FACL4; LACS4; Long-chain-fatty-acid--CoA ligase 4; Arachidonate--CoA ligase; Long-chain acyl-CoA synthetase 4; LACS 4 | ||||||
| Raised in | Rabbit | ||||||
| Species Reactivity | Human | ||||||
| Immunogen | Recombinant Human Long-chain-fatty-acid--CoA ligase 4 protein (457-670AA) | ||||||
| Immunogen Species | Homo sapiens (Human) | ||||||
| Conjugate | Non-conjugated The ACSL4 Antibody (Product code: CSB-PA060488EA01HU) is Non-conjugated. For ACSL4 Antibody with conjugates, please check the following table. |
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| Clonality | Polyclonal | ||||||
| Isotype | IgG | ||||||
| Purification Method | >95%, Protein G purified | ||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
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| Form | Liquid | ||||||
| Tested Applications | ELISA, WB, IHC | ||||||
| Recommended Dilution |
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| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
Applications : Western Blot
Sample type: Huh7 cells
Review: Compared to Huh7 cells, p-AMPKα/AMPKα ratio was significantly decreased, levels of adipocytokines including ACSBG1, ADIPOQ, ACSL4 were increased as well as intracellular level of lipid peroxidation product MDA was decreased in Huh7-SOR cells, as shown in above values.
By Anonymous
| Function |
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs. Modulates prostaglandin E2 secretion.
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| Gene References into Functions |
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| Involvement in disease | Mental retardation, X-linked 63 (MRX63); Alport syndrome with mental retardation, midface hypoplasia and elliptocytosis (ATS-MR) |
| Subcellular Location | Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Cell membrane. |
| Protein Families | ATP-dependent AMP-binding enzyme family |
| Database Links |
HGNC: 3571 OMIM: 300157 KEGG: hsa:2182 STRING: 9606.ENSP00000339787 UniGene: Hs.268785 |
