ACY1 Antibody

1. with the elevated level in the disease progression of Chronic hepatitis B (CHB), ACY1 autoantibody may be a valuable serum biomarker for discriminating HBVrelated liver cirrhosis from CHB. PMID: 27633755
2. Biochemical analysis showed absence of ACY1 enzyme activity in the patient's fibroblasts. PMID: 24117009
3. ACY1 acts as a tumor suppressor in hepatocellular carcinoma. PMID: 24846301
4. Report serum aminoacylase-1 as a novel biomarker with potential prognostic utility for long-term outcome in renal transplant recipients with delayed graft function. PMID: 23739232
5. Case Report: ACY1-deficient patient presenting with autistic features. PMID: 20480396
6. We concluded that ACY1 expression in colorectal cancer varies with stage and appears to play a role in cell proliferation and apoptosis PMID: 23317546
7. These data suggest that aminoacylase expression is dysregulated in neuroblastoma. PMID: 21128244
8. aminoacylase 1 proteins with the mutations p.Arg378Trp, p.Arg378Gln and p.Arg393His were also detected in Western blot analysis PMID: 21414403
9. by complementing different active site mutants of human aminoacylase-1, study shows that catalysis occurs at the dimer interface PMID: 12933810
10. first report of a patient with aminoacylase I deficiency PMID: 16274666
11. Genetic deficiency of ACY1 leads to functional ACY1 deficiency and excretion of N-acetylated amino acids. PMID: 16465618
12. Because hK1 amidase activity is significantly lower in urine of systolic HF patients, it can be supposed that activity of renal kallikrein-kinin system may be suppressed in this systolic heart failure. PMID: 17045186
13. T347S variant of human Acy1 exhibited markedly increased catalytic efficiency against N-benzoylamino acids PMID: 18341290

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HGNC: 177

OMIM: 104620

KEGG: hsa:95

STRING: 9606.ENSP00000384296

UniGene: Hs.334707