ADCY6 Antibody

Code CSB-PA001342LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA001342LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA001342LA01HU at dilution of 1:100

  • Immunofluorescence staining of Hela cells with CSB-PA001342LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ADCY6 Polyclonal antibody
Uniprot No. O43306
Target Names ADCY6
Alternative Names AC6 antibody; ACVI antibody; ADCY 6 antibody; Adcy6 antibody; ADCY6_HUMAN antibody; ADCYB antibody; Adenylate cyclase 6 antibody; Adenylate cyclase type 6 antibody; Adenylate cyclase type VI antibody; Adenylyl cyclase 6 antibody; ATP pyrophosphate lyase 6 antibody; ATP pyrophosphate-lyase 6 antibody; Ca(2+) inhibitable adenylyl cyclase antibody; Ca(2+)-inhibitable adenylyl cyclase antibody; DKFZp779F075 antibody; EC 4.6.1.1 antibody; KIAA0422 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Adenylate cyclase type 6 protein (9-118AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors
Gene References into Functions
  1. rs3730071G/T and rs77913913G/T of ADCY6 were non-polymorphic with respect to HAPE. PMID: 29443612
  2. model suggests Cys1004 in AC6 (subunit C2) and Cys174 in Galphas present at the AC-Galphas interface as the possible residues that might undergo reversible nitrosylation. Docking analysis predicted novel ligands of AC6 that include forskolin-based compounds and its derivatives. PMID: 29327289
  3. Sickle cell anemia patients carrying at least one allele of adcy6 rs3730070-G exhibited lower hemolytic rate than non-carriers in univariate analysis (p=0.006). PMID: 27067484
  4. Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects PMID: 24319099
  5. AC6 localizes in lipid raft fractions of bronchial airway smooth muscle where it is stimulated by beta2 adrenergic- and prostacyclin receptors and inhibited by divalent calcium ions. PMID: 21228062
  6. In addition to its direct effect on renin gene transcription, PPARgamma "sensitizes" renin gene to cAMP via trans-activation of AC6 gene. PMID: 20861226
  7. identified a single nucleotide polymorphism that may play a role in developing left ventricular hypertrophy PMID: 14871025
  8. Raf1 potentiates drug-stimulated cyclic AMP accumulation in cells expressing adenyl cyclcase 6 after activation of multiple signaling pathways. PMID: 15470083
  9. A2bR signals through adenylate cyclase (AC) 6 isoform in intestinal epithelial cells PMID: 16631311
  10. AC6 overexpression in endothelial cells may have use as a means to enhance prostacyclin function and reduce endothelial barrier permeability. PMID: 16885208
  11. These data show that, in an animal model that mimics key aspects of clinical congestive heart failure, cardiac gene transfer of ACVI increases function of the failing heart. PMID: 17007567
  12. Expression of a novel, relatively common variant of ADCY6 parallels an increase in adenylyl cyclase activity and adenylyl cyclase-mediated function in humans. PMID: 17916776
  13. Parathyroid hormone communicates with IP(3)R via "cAMP junctions" that allow local delivery of a supramaximal concentration of cAMP to IP(3)R, directly increasing their sensitivity to IP(3). PMID: 18936250
  14. The catalytic domains (C1 and C2) of adenylate cyclase 6 play a role in targeting adenylate cyclase 6 to lipid rafts. PMID: 19007881
  15. Instead the knock down of the predominant subtype AC6 in HUVECs provided the first direct evidence that the Ca(2+)-mediated inhibition of AC6 accounts for the thrombin-induced decrease in cAMP levels. PMID: 19546162

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Involvement in disease Lethal congenital contracture syndrome 8 (LCCS8)
Subcellular Location Cell membrane, Multi-pass membrane protein, Cell projection, cilium
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity Detected in peripheral blood mononuclear leukocytes (at protein level) (PubMed:17916776). Detected in thyroid (PubMed:10978539).
Database Links

HGNC: 237

OMIM: 600294

KEGG: hsa:112

STRING: 9606.ENSP00000311405

UniGene: Hs.525401

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