ADGRB2 Antibody, HRP conjugated

Code CSB-PA523985LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ADGRB2 Polyclonal antibody
Uniprot No.
Target Names
ADGRB2
Alternative Names
ADGRB2 antibody; BAI2Adhesion G protein-coupled receptor B2 antibody; Brain-specific angiogenesis inhibitor 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Adhesion G protein-coupled receptor B2 protein (1371-1545AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition.
Gene References into Functions
  1. These studies provide new insights into the signaling capabilities of the adhesion GPCR BAI2/ADGRB2 and shed light on how an apparent gain-of-function mutation to the receptor's C-terminus may lead to human disease. PMID: 28891236
  2. This is the first study reporting BAI2 as an interaction partner of GIP. PMID: 21787750
  3. BAI2 is a functional GPCR regulated by proteolytic processing and activates the NFAT pathway PMID: 20367554
  4. involvement of BAI2 in the ischemia-induced brain angiogenesis PMID: 12218411
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
Tissue Specificity
Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.
Database Links

HGNC: 944

OMIM: 602683

KEGG: hsa:576

STRING: 9606.ENSP00000362762

UniGene: Hs.524138

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