BAI2 Antibody

Code CSB-PA999579
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA999579(ADGRB2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA999579(ADGRB2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
ADGRB2
Alternative Names
ADGRB2 antibody; BAI2Adhesion G protein-coupled receptor B2 antibody; Brain-specific angiogenesis inhibitor 2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide of Human ADGRB2
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
IHC 1:25-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition.
Gene References into Functions
  1. These studies provide new insights into the signaling capabilities of the adhesion GPCR BAI2/ADGRB2 and shed light on how an apparent gain-of-function mutation to the receptor's C-terminus may lead to human disease. PMID: 28891236
  2. This is the first study reporting BAI2 as an interaction partner of GIP. PMID: 21787750
  3. BAI2 is a functional GPCR regulated by proteolytic processing and activates the NFAT pathway PMID: 20367554
  4. involvement of BAI2 in the ischemia-induced brain angiogenesis PMID: 12218411
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
Tissue Specificity
Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.
Database Links

HGNC: 944

OMIM: 602683

KEGG: hsa:576

STRING: 9606.ENSP00000362762

UniGene: Hs.524138

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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