ADGRB2 Antibody

Datasheet

Code	CSB-PA523985LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Rat brain tissue All lanes: ADGRB2 antibody at 3.2μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 173, 172, 170 kDa Observed band size: 173 kDa Immunofluorescent analysis of HepG2 cells using CSB-PA523985LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ADGRB2 Polyclonal antibody

Uniprot No.

O60241

Target Names

ADGRB2

Alternative Names

ADGRB2 antibody; BAI2Adhesion G protein-coupled receptor B2 antibody; Brain-specific angiogenesis inhibitor 2 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Adhesion G protein-coupled receptor B2 protein (1371-1545AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ADGRB2 Antibody (Product code: CSB-PA523985LA01HU) is Non-conjugated. For ADGRB2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA523985LB01HU	ADGRB2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA523985LC01HU	ADGRB2 Antibody, FITC conjugated
Biotin	CSB-PA523985LD01HU	ADGRB2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition.

Gene References into Functions

These studies provide new insights into the signaling capabilities of the adhesion GPCR BAI2/ADGRB2 and shed light on how an apparent gain-of-function mutation to the receptor's C-terminus may lead to human disease. PMID: 28891236
This is the first study reporting BAI2 as an interaction partner of GIP. PMID: 21787750
BAI2 is a functional GPCR regulated by proteolytic processing and activates the NFAT pathway PMID: 20367554
involvement of BAI2 in the ischemia-induced brain angiogenesis PMID: 12218411

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily

Tissue Specificity

Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.

Database Links

HGNC: 944

OMIM: 602683

KEGG: hsa:576

STRING: 9606.ENSP00000362762

UniGene: Hs.524138

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

G protein coupled receptor signaling pathway Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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