ALDH1B1 Antibody

Code CSB-PA001568GA01HU
Size US$685
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Product Details

Uniprot No. P30837
Target Names ALDH1B1
Alternative Names Acetaldehyde dehydrogenase 5 antibody; AL1B1_HUMAN antibody; Aldehyde dehydrogenase 1 family; member B1 antibody; Aldehyde dehydrogenase 1B1 antibody; Aldehyde dehydrogenase 5 antibody; Aldehyde dehydrogenase family 1 member B1 antibody; Aldehyde dehydrogenase X antibody; Aldehyde dehydrogenase X mitochondrial antibody; ALDH class 2 antibody; Aldh1b1 antibody; ALDH5 antibody; ALDHX antibody; MGC2230 antibody; Mitochondrial aldehyde dehydrogenase X antibody; mitochondrial antibody; OTTHUMP00000021399 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human ALDH1B1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
Gene References into Functions
  1. These results suggest that ALDH1B1 is a novel human colorectal cancer biomarker PMID: 28881356
  2. The aims of this study were: (i) to use bioinformatic techniques to characterize the possible effects of selected variants in ALDH1B1 on protein structure and function; and, (ii) to genotype three missense and one stop-gain, protein-altering, non-synonymous single nucleotide polymorphisms in 1478 alcohol dependent cases and 1254 controls of matched British and Irish ancestry. PMID: 28594837
  3. ALDH1B1 is expressed at very high levels in human pancreatic cancer, and it contributes to proliferation in these tumor cells. PMID: 26566217
  4. High expression of ALDH1A2 and ALDH1B1 mRNA was found to be significantly correlated to worser survival in all NSCLC patients. PMID: 26366059
  5. Data show that ALDH1B1 may promote colon cancer tumorigenesis by modulating the Wnt/beta-catenin, Notch and PI3K/Akt signaling pathways. PMID: 25950950
  6. ALDH1B1 metabolizes nitroglycerin and all-trans-retinaldehyde. One of the three human polymorphisms, ALDH1B1*2, is catalytically inactive, likely due to poor NAD(+) binding. PMID: 25413692
  7. ALDH1B1 SNPs play a role in shaping the alcohol drinking patterns among the Inuit in Greenland. PMID: 25311581
  8. ALDH1 is indicative of stemness and is a biomarker marker in colon cancer. PMID: 24953984
  9. ALDH1B1 is more profoundly expressed in the adenocarcinomas examined in this study relative to ALDH1A1 and that ALDH1B1 is dramatically upregulated in human colonic adenocarcinoma, making it a potential biomarker for human colon cancer. PMID: 21216231
  10. An ALDHX model based on the crystal structure of human ALDH2, reveals similarities with the previously described ALDH structures. Analyses indicate a close structural and functional relationship between the two isoenzymes of human origin PMID: 20955166
  11. a common SNP encoding ALDH1b1 (rs2228093) was found to be significantly associated with alcohol-induced hypersensitivity. PMID: 20205700
  12. ALDH1b1 ala69val was associated with diastolic blood pressure in a Caucasian population sample PMID: 18782342

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Subcellular Location Mitochondrion matrix
Protein Families Aldehyde dehydrogenase family
Tissue Specificity Liver, testis and to a lesser extent in brain.
Database Links

HGNC: 407

OMIM: 100670

KEGG: hsa:219

STRING: 9606.ENSP00000366927

UniGene: Hs.436219

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