ALKBH4 Antibody

Code CSB-PA001610GA01HU
Size US$685
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Product Details

Uniprot No. Q9NXW9
Target Names ALKBH4
Alternative Names 2010004B12Rik antibody; ABH4 antibody; Abj4 antibody; AlkB; alkylation repair homolog 4 (E. coli) antibody; ALKB4_HUMAN antibody; Alkbh4 antibody; Alkylated DNA repair protein alkB homolog 4 antibody; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 antibody; FLJ20013 antibody; Probable alpha-ketoglutarate dependent dioxygenase ABH4 antibody; RGD1308608 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human ALKBH4
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IF
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation.
Gene References into Functions
  1. ALKBH4-dependent actin demethylation regulates actomyosin function by promoting actin-non-muscle myosin II interaction. PMID: 23673617
  2. The regions mediating binding to ALKBH4 comprised domains previously reported to be involved in interaction with DNA or chromatin. PMID: 23145062
  3. ALKBH4 represents an active Fe(II)/2OG-dependent decarboxylase and suggest that the cysteine cluster is involved in processes other than Fe co-ordination. PMID: 21166655
Subcellular Location Cytoplasm, Nucleus, Midbody
Protein Families AlkB family
Tissue Specificity Widely expressed, with highest expression in pancreas, ovary and spleen.
Database Links

HGNC: 21900

OMIM: 613302

KEGG: hsa:54784

STRING: 9606.ENSP00000292566

UniGene: Hs.658598

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