AMD1 Antibody

Code CSB-PA776176
Size US$166
Order now
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA776176(AMD1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA776176(AMD1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: PC3 cells, human seminoma tissue, mouse testis tissue, Primary antibody: CSB-PA776176(AMD1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Target Names
AMD1
Alternative Names
Adenosylmethionine decarboxylase 1 antibody; AdoMetDC antibody; AMD1 antibody; DCAM_HUMAN antibody; EC 4.1.1.50 antibody; FLJ26964 antibody; S adenosylmethionine decarboxylase 1 antibody; S adenosylmethionine decarboxylase proenzyme antibody; S-adenosylmethionine decarboxylase beta chain antibody; SAMDC antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide of Human AMD1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
Gene References into Functions
  1. AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation PMID: 29310120
  2. AMD1 is upregulated in human prostate cancer with activated mTORC1 PMID: 28658205
  3. AMD1 gene variants previously found to associate among Indian children did not associate with risk of obesity or obesity-related quantitative measures among Caucasian children and juvenile men from Denmark. PMID: 26558825
  4. Gene expression studies have identified altered expression of AMD1 in suicide completers with a history of mood disorders. PMID: 23260169
  5. This study demomistrated that H3K4me3 modification plays an important role in up regulation of AMD1 in prefrontal cortex. PMID: 22008221
  6. Genetic variant of AMD1 is associated with obesity. PMID: 22496743
  7. Overexpression of S-adenosylmethionine decarboxylase in rodent fibroblasts led to aggressive transformants. PMID: 21134486
  8. Decreased AMD1 is associated with prostate cancer. PMID: 20215859
  9. AdoMetDC is ubiquitinated and degraded by the 26 S proteasome PMID: 14718534
  10. The adhesion-dependent expression of SAM-DC and ODC contributes to extracellular matrix-dependent salivary gland cell differentiation. PMID: 15521072
  11. For such cells, gamma-radiation and cisplatin, which are direct DNA-damaging agents, were very effective for promoting cell death. PMID: 17069747
  12. schizophrenia and bipolar disorder patients, the increase of S-adenosyl methionine is associated with an overexpression of DNA methyltransferase-1 mRNA in Brodmann's area 9 GABAergic neurons. PMID: 17259861
  13. Antisense RNA specifically inhibited the expression of ODC and AdoMetDC and the synthesis of polyamine, while it induced p21 expression, resulting in cell growth arrest in the G1 phase in prostate cancer cells PMID: 18548481
  14. Binding of putrescine to wild type dimeric ADOMETDC protein is cooperative; putrescine activates the enzyme through electrostatic effects and acts as a switch to correctly orient key catalytic residues. PMID: 19053272
  15. determined crystal structures cocrystallized with 5'-deoxy-5'-dimethylthioadenosine and 5'-deoxy-5'-(N-dimethyl)amino-8-methyladenosine. The crystal structures revealed cation-pi interaction between the ligand and aromatic side chains of Phe7 and Phe223 PMID: 19527050

Show More

Hide All

Protein Families
Eukaryotic AdoMetDC family
Database Links

HGNC: 457

OMIM: 180980

KEGG: hsa:262

STRING: 9606.ENSP00000357880

UniGene: Hs.159118

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*