AMD1 Antibody

1. AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation PMID: 29310120
2. AMD1 is upregulated in human prostate cancer with activated mTORC1 PMID: 28658205
3. AMD1 gene variants previously found to associate among Indian children did not associate with risk of obesity or obesity-related quantitative measures among Caucasian children and juvenile men from Denmark. PMID: 26558825
4. Gene expression studies have identified altered expression of AMD1 in suicide completers with a history of mood disorders. PMID: 23260169
5. This study demomistrated that H3K4me3 modification plays an important role in up regulation of AMD1 in prefrontal cortex. PMID: 22008221
6. Genetic variant of AMD1 is associated with obesity. PMID: 22496743
7. Overexpression of S-adenosylmethionine decarboxylase in rodent fibroblasts led to aggressive transformants. PMID: 21134486
8. Decreased AMD1 is associated with prostate cancer. PMID: 20215859
9. AdoMetDC is ubiquitinated and degraded by the 26 S proteasome PMID: 14718534
10. The adhesion-dependent expression of SAM-DC and ODC contributes to extracellular matrix-dependent salivary gland cell differentiation. PMID: 15521072
11. For such cells, gamma-radiation and cisplatin, which are direct DNA-damaging agents, were very effective for promoting cell death. PMID: 17069747
12. schizophrenia and bipolar disorder patients, the increase of S-adenosyl methionine is associated with an overexpression of DNA methyltransferase-1 mRNA in Brodmann's area 9 GABAergic neurons. PMID: 17259861
13. Antisense RNA specifically inhibited the expression of ODC and AdoMetDC and the synthesis of polyamine, while it induced p21 expression, resulting in cell growth arrest in the G1 phase in prostate cancer cells PMID: 18548481
14. Binding of putrescine to wild type dimeric ADOMETDC protein is cooperative; putrescine activates the enzyme through electrostatic effects and acts as a switch to correctly orient key catalytic residues. PMID: 19053272
15. determined crystal structures cocrystallized with 5'-deoxy-5'-dimethylthioadenosine and 5'-deoxy-5'-(N-dimethyl)amino-8-methyladenosine. The crystal structures revealed cation-pi interaction between the ligand and aromatic side chains of Phe7 and Phe223 PMID: 19527050

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HGNC: 457

OMIM: 180980

KEGG: hsa:262

STRING: 9606.ENSP00000357880

UniGene: Hs.159118