AMD1 Antibody

Datasheet

Code	CSB-PA001568LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate All lanes: AMD1 antibody at 2.5µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 39, 22 kDa Observed band size: 39 kDa Immunofluorescent analysis of HepG2 cells using CSB-PA001568LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) AMD1 Polyclonal antibody

Uniprot No.

P17707

Target Names

AMD1

Alternative Names

Adenosylmethionine decarboxylase 1 antibody; AdoMetDC antibody; AMD1 antibody; DCAM_HUMAN antibody; EC 4.1.1.50 antibody; FLJ26964 antibody; S adenosylmethionine decarboxylase 1 antibody; S adenosylmethionine decarboxylase proenzyme antibody; S-adenosylmethionine decarboxylase beta chain antibody; SAMDC antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human S-adenosylmethionine decarboxylase proenzyme protein (167-264AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The AMD1 Antibody (Product code: CSB-PA001568LA01HU) is Non-conjugated. For AMD1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA001568LB01HU	AMD1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA001568LC01HU	AMD1 Antibody, FITC conjugated
Biotin	CSB-PA001568LD01HU	AMD1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.

Gene References into Functions

AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation PMID: 29310120
AMD1 is upregulated in human prostate cancer with activated mTORC1 PMID: 28658205
AMD1 gene variants previously found to associate among Indian children did not associate with risk of obesity or obesity-related quantitative measures among Caucasian children and juvenile men from Denmark. PMID: 26558825
Gene expression studies have identified altered expression of AMD1 in suicide completers with a history of mood disorders. PMID: 23260169
This study demomistrated that H3K4me3 modification plays an important role in up regulation of AMD1 in prefrontal cortex. PMID: 22008221
Genetic variant of AMD1 is associated with obesity. PMID: 22496743
Overexpression of S-adenosylmethionine decarboxylase in rodent fibroblasts led to aggressive transformants. PMID: 21134486
Decreased AMD1 is associated with prostate cancer. PMID: 20215859
AdoMetDC is ubiquitinated and degraded by the 26 S proteasome PMID: 14718534
The adhesion-dependent expression of SAM-DC and ODC contributes to extracellular matrix-dependent salivary gland cell differentiation. PMID: 15521072
For such cells, gamma-radiation and cisplatin, which are direct DNA-damaging agents, were very effective for promoting cell death. PMID: 17069747
schizophrenia and bipolar disorder patients, the increase of S-adenosyl methionine is associated with an overexpression of DNA methyltransferase-1 mRNA in Brodmann's area 9 GABAergic neurons. PMID: 17259861
Antisense RNA specifically inhibited the expression of ODC and AdoMetDC and the synthesis of polyamine, while it induced p21 expression, resulting in cell growth arrest in the G1 phase in prostate cancer cells PMID: 18548481
Binding of putrescine to wild type dimeric ADOMETDC protein is cooperative; putrescine activates the enzyme through electrostatic effects and acts as a switch to correctly orient key catalytic residues. PMID: 19053272
determined crystal structures cocrystallized with 5'-deoxy-5'-dimethylthioadenosine and 5'-deoxy-5'-(N-dimethyl)amino-8-methyladenosine. The crystal structures revealed cation-pi interaction between the ligand and aromatic side chains of Phe7 and Phe223 PMID: 19527050

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Protein Families

Eukaryotic AdoMetDC family

Database Links

HGNC: 457

OMIM: 180980

KEGG: hsa:262

STRING: 9606.ENSP00000357880

UniGene: Hs.159118

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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