AMOTL2 Antibody

Datasheet

Code	CSB-PA809099NA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: 293T whole cell lysate, U251 whole cell lysate, HepG2 whole cell lysate, 293 whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate, PC3 whole cell lysate All lanes: AMOTL2 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 86, 92 kDa Observed band size: 86 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) AMOTL2 Polyclonal antibody

Uniprot No.

Q9Y2J4

Target Names

AMOTL2

Alternative Names

AMOL2_HUMAN antibody; Amotl2 antibody; angiomotin like 2 antibody; Angiomotin-like protein 2 antibody; KIAA0989 antibody; LCCP antibody; Leman coiled coil protein antibody; Leman coiled-coil protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Peptide sequence from Human Angiomotin-like protein 2 protein (718-737AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The AMOTL2 Antibody (Product code: CSB-PA809099NA01HU) is Non-conjugated. For AMOTL2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA809099NB01HU	AMOTL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA809099NC01HU	AMOTL2 Antibody, FITC conjugated
Biotin	CSB-PA809099ND01HU	AMOTL2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.

Gene References into Functions

these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP and AKT in liver size control and cancer prevention PMID: 28368415
AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients. PMID: 25080976
These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process. PMID: 23525008
AMOTL2 interacts with TAZ and modulates transcriptional activity of TAZ. PMID: 23911299
Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells PMID: 21937427

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Subcellular Location

Recycling endosome.

Protein Families

Angiomotin family

Database Links

HGNC: 17812

OMIM: 614658

KEGG: hsa:51421

STRING: 9606.ENSP00000249883

UniGene: Hs.426312

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Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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