AMOTL2 Antibody

Code CSB-PA809099NA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: 293T whole cell lysate, U251 whole cell lysate, HepG2 whole cell lysate, 293 whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate, PC3 whole cell lysate
    All lanes: AMOTL2 antibody at 1:2000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 86, 92 kDa
    Observed band size: 86 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) AMOTL2 Polyclonal antibody
Uniprot No.
Target Names
AMOTL2
Alternative Names
AMOL2_HUMAN antibody; Amotl2 antibody; angiomotin like 2 antibody; Angiomotin-like protein 2 antibody; KIAA0989 antibody; LCCP antibody; Leman coiled coil protein antibody; Leman coiled-coil protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence from Human Angiomotin-like protein 2 protein (718-737AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The AMOTL2 Antibody (Product code: CSB-PA809099NA01HU) is Non-conjugated. For AMOTL2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA809099NB01HU AMOTL2 Antibody, HRP conjugated ELISA
FITC CSB-PA809099NC01HU AMOTL2 Antibody, FITC conjugated
Biotin CSB-PA809099ND01HU AMOTL2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
Gene References into Functions
  1. these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP and AKT in liver size control and cancer prevention PMID: 28368415
  2. AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients. PMID: 25080976
  3. These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process. PMID: 23525008
  4. AMOTL2 interacts with TAZ and modulates transcriptional activity of TAZ. PMID: 23911299
  5. Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells PMID: 21937427

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Subcellular Location
Recycling endosome.
Protein Families
Angiomotin family
Database Links

HGNC: 17812

OMIM: 614658

KEGG: hsa:51421

STRING: 9606.ENSP00000249883

UniGene: Hs.426312

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