AMPH Antibody

Code CSB-PA001683GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
AMPH
Alternative Names
Amp antibody; AMPH 1 antibody; AMPH antibody; AMPH_HUMAN antibody; AMPH1 antibody; Amphiphysin (Stiff-Man syndrome with breast cancer 128kD autoantigen) antibody; Amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen) antibody; Amphiphysin antibody; Amphiphysin I antibody; CG8604 antibody; Damp antibody; dAmph antibody; Dmel\CG8604 antibody; HGNC:471 antibody; MGC49429 antibody; Stiff man syndrome with breast cancer 128kD autoantigen antibody; Stiff man syndrome with breast cancer 128kDa autoantigen antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human AMPH
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.
Gene References into Functions
  1. The data show that the dynamin-amphiphysin helices are rearranged to form clusters upon GTP hydrolysis and membrane constriction occurs at protein-uncoated regions flanking the clusters. PMID: 29357276
  2. We show that AMPH-1/BIN1 binds to nesprin and actin, as well as to the microtubule-binding protein CLIP170 in both species. We propose that BIN1 has a direct and evolutionarily conserved role in nuclear positioning, altered in myopathies. PMID: 26506308
  3. It is a nerve protein and its autoantibody causes paraneoplastic neurological syndromes. PMID: 25087559
  4. AMPH1 protein level is reduced in transgenic mouse brain proteins. in the brainstem of nontransgenic and terminally ill JNPL3 transgenic mice. PMID: 22975846
  5. We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome PMID: 22331304
  6. structure-based approach to prediction of peptide-binding behavior of SH3 domain of amphiphysin-1: statistical modeling PMID: 19669081
  7. investigation of binding affinities of decapeptide ligands with amphiphysin SH3 domain using QSAR models PMID: 20214647
  8. Female patient with amphiphysin autoantibodies and siff leg syndrome due to small cell cancer of the lung. PMID: 16671079
  9. Amphiphysin I (Amph I) is a minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase substrate. Amph I phosphorylation changes the recruitment of endophilin at the endocytic sites. PMID: 16733250
  10. This study demonstrates that the analysis of the molecular interaction energy components between peptides and the SH3 domain can successfully characterize the binding interface. PMID: 18206907
  11. Analyses of Gaussian distribution models showed that diversified properties contribute to the interactions between the SH3 domain and of amphiphysin and peptides. PMID: 18814309

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Subcellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Tissue Specificity
Neurons, certain endocrine cell types and spermatocytes.
Database Links

HGNC: 471

OMIM: 600418

KEGG: hsa:273

STRING: 9606.ENSP00000348602

UniGene: Hs.592182

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