ARC Antibody

Code CSB-PA001981GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
ARC
Alternative Names
activity regulated cytoskeleton associated protein antibody; activity regulated gene 3.1 protein homolog antibody; Activity-regulated cytoskeleton-associated protein antibody; Activity-regulated gene 3.1 protein homolog antibody; Arc antibody; ARC/ARG3.1 antibody; ARC_HUMAN antibody; Arg 3.1 antibody; Arg3.1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human ARC
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory. Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1. In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation.
Gene References into Functions
  1. The ARC complex revealed association with verbal and total IQ in child. PMID: 28671113
  2. Study identified several rare mutations that reduced ARC expression in schizophrenia patients. Furthermore, DNA methylation of ARC in schizophrenia patients may be associated with a downregulation of ARC mRNA expression. These findings suggest that multiple rare ARC variants and DNA methylation of ARC might contribute to the pathogenesis of schizophrenia. PMID: 27464451
  3. missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc, disrupting Arc ubiquitination, and consequently Arc degradation. PMID: 27995769
  4. ARC confers resistance to sunitinib in renal cell carcinoma through alternate angiogenesis pathways PMID: 26995091
  5. We tested whether ARC variants are associated with six measures of cognitive functioning in 670 healthy subjects in the Norwegian Cognitive NeuroGenetics (NCNG) by extracting data from its Genome-Wide Association Study (GWAS). PMID: 26516611
  6. this is the first report associating an ARC SNP with schizophrenia and supports recent large-scale GWAS findings implicating the ARC complex in schizophrenia risk PMID: 26474411
  7. we propose that the peculiar characteristics of Arc protein, such as its optimal expression after ongoing experience or familiar behavior could explain how familiarization and recognition memories are stored and preserved in the mammalian brain--{REVIEW} PMID: 26380114
  8. mRNA levels of ARC and SGK1 did not differ significantly between the schizophrenia or control samples. PMID: 26038830
  9. Arc is a flexible multi-domain protein that exists in monomeric and oligomeric forms, compatible with a diverse, hub-like role in plasticity-related processes. PMID: 25748042
  10. Degradation of Arc by clathrin-localized Triad3A regulates the availability of synaptic AMPA receptors. PMID: 24945773
  11. we report a novel ARC single nucleotide polymorphism associated with a reduced risk of developing Alzheimer disease. PMID: 22622366
  12. analysis of dynamic, multifaceted control of Arc synthesis during mAchR signaling PMID: 22584581
  13. Strong fibrinogen and Abeta deposition is demonstrated in small- and medium-sized vessels, but not in large cerebral arteries, of 24-month-old transgenic arcAbeta mice. PMID: 22302811
  14. Arc Expression Is Increased in medial frontal cortex of patients with Alzheimer's Disease. PMID: 22036569
  15. Arc/MS2 mRNA assembles into particles that move independently, bidirectionally, and intermittently. These observations identify several phases of Arc mRNA movement that serve as potential points for regulating Arc mRNA localization. PMID: 17120280

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Subcellular Location
Extracellular vesicle membrane; Lipid-anchor. Cell junction, synapse, postsynaptic cell membrane; Lipid-anchor. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Early endosome membrane. Cell projection, dendrite. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell projection, dendritic spine. Cytoplasmic vesicle, secretory vesicle, acrosome.
Protein Families
ARC/ARG3.1 family
Database Links

HGNC: 648

OMIM: 612461

KEGG: hsa:23237

STRING: 9606.ENSP00000349022

UniGene: Hs.40888

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