ARHGEF11 Antibody

Datasheet

Code	CSB-PA002043LA01HU
Size	US$166
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Image	IHC image of CSB-PA002043LA01HU diluted at 1:500 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ARHGEF11 Polyclonal antibody

Uniprot No.

O15085

Target Names

ARHGEF11

Alternative Names

ARHGB_HUMAN antibody; ARHGEF 11 antibody; ARHGEF11 antibody; DKFZp667F1223 antibody; Glutamate transporter EAAT4 associated protein 48 antibody; GTRAP 48 antibody; GTRAP48 antibody; KIAA0380 antibody; OTTHUMP00000038716 antibody; OTTHUMP00000038717 antibody; PDZ RHOGEF antibody; PDZ-RhoGEF antibody; Rho guanine exchange factor (GEF) 11 antibody; Rho guanine nucleotide exchange factor (GEF) 11 antibody; Rho guanine nucleotide exchange factor 11 antibody; RhoA specific guanine nucleotide exchange factor antibody; RhoGEF glutamate transport modulator antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Rho guanine nucleotide exchange factor 11 protein (1221-1318AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ARHGEF11 Antibody (Product code: CSB-PA002043LA01HU) is Non-conjugated. For ARHGEF11 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA002043LB01HU	ARHGEF11 Antibody, HRP conjugated	ELISA
FITC	CSB-PA002043LC01HU	ARHGEF11 Antibody, FITC conjugated
Biotin	CSB-PA002043LD01HU	ARHGEF11 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.

Gene References into Functions

PAK4 (but not PAK1) mediates invadopodia maturation during melanoma invasion likely via inhibition of PDZ-RhoGEF. PMID: 27765920
Data show that endothelin A receptor drives invadopodia function by direct interaction of beta-arrestin-1 (beta-arr1) with Rho guanine nucleotide exchange factor (GEF) 11 protein (PDZ-RhoGEF). PMID: 26522724
Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling. PMID: 26627240
Results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia PMID: 25319871
Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study. PMID: 24106280
analysis of molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF PMID: 21816819
The R1467H polymorphism of ARHGEF11 gene may contribute to susceptibility to type 2 diabetes mellitus and insulin resistance in a Chinese population. PMID: 21210224
Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho-GEF(LARG) and this protein. PMID: 12183458
PDZ-RhoGEF interacts directly with p21-activated kinase 4 to negatively regulate the activation of Rho PMID: 14625312
ARHGER11 is involved in the pathologic changes associated with decreased glutamatergic neurotransmission in schizophrenia PMID: 14684465
PDZ-RhoGEF interacts with the actin cytoskeleton PMID: 14742719
This is the first epidemiological study to link PDZ-RhoGEF polymorphisms with cancer risk, specifically in Mexican Americans at risk for lung cancer. PMID: 16691626
Variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance. PMID: 17287471
Sequence variation in this gene may influence susceptibility to and risk of type II diabetes. PMID: 17369523
PDZRhoGEF (PRG), mediates RhoA-dependent responses and determines their spatial distribution in differentiated HL60 cells. PMID: 18086913
R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians. PMID: 18231709
the autoinhibition of PRG is caused largely by an interaction of a short negatively charged sequence motif, immediately upstream of the DH-domain. PMID: 19460155
The actin-binding domain of PDZ-RhoGEF, located between amino acids 561 and 585, directly binds to F-actin in vitro and could influence actin structure in a manner independent of its ability to activate RhoA. PMID: 19618964
PYK2 and PDZ-RhoGEF are necessary for angiotensin II-induced RhoA activation and for Ca(2+) signaling to RhoA. PMID: 19759375

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Subcellular Location

Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation.

Tissue Specificity

Ubiquitously expressed.

Database Links

HGNC: 14580

OMIM: 605708

KEGG: hsa:9826

STRING: 9606.ENSP00000357177

UniGene: Hs.516954

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Vascular smooth muscle contraction

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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