ARHGEF11 Antibody

1. PAK4 (but not PAK1) mediates invadopodia maturation during melanoma invasion likely via inhibition of PDZ-RhoGEF. PMID: 27765920
2. Data show that endothelin A receptor drives invadopodia function by direct interaction of beta-arrestin-1 (beta-arr1) with Rho guanine nucleotide exchange factor (GEF) 11 protein (PDZ-RhoGEF). PMID: 26522724
3. Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling. PMID: 26627240
4. Results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia PMID: 25319871
5. Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study. PMID: 24106280
6. analysis of molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF PMID: 21816819
7. The R1467H polymorphism of ARHGEF11 gene may contribute to susceptibility to type 2 diabetes mellitus and insulin resistance in a Chinese population. PMID: 21210224
8. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho-GEF(LARG) and this protein. PMID: 12183458
9. PDZ-RhoGEF interacts directly with p21-activated kinase 4 to negatively regulate the activation of Rho PMID: 14625312
10. ARHGER11 is involved in the pathologic changes associated with decreased glutamatergic neurotransmission in schizophrenia PMID: 14684465
11. PDZ-RhoGEF interacts with the actin cytoskeleton PMID: 14742719
12. This is the first epidemiological study to link PDZ-RhoGEF polymorphisms with cancer risk, specifically in Mexican Americans at risk for lung cancer. PMID: 16691626
13. Variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance. PMID: 17287471
14. Sequence variation in this gene may influence susceptibility to and risk of type II diabetes. PMID: 17369523
15. PDZRhoGEF (PRG), mediates RhoA-dependent responses and determines their spatial distribution in differentiated HL60 cells. PMID: 18086913
16. R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians. PMID: 18231709
17. the autoinhibition of PRG is caused largely by an interaction of a short negatively charged sequence motif, immediately upstream of the DH-domain. PMID: 19460155
18. The actin-binding domain of PDZ-RhoGEF, located between amino acids 561 and 585, directly binds to F-actin in vitro and could influence actin structure in a manner independent of its ability to activate RhoA. PMID: 19618964
19. PYK2 and PDZ-RhoGEF are necessary for angiotensin II-induced RhoA activation and for Ca(2+) signaling to RhoA. PMID: 19759375

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HGNC: 14580

OMIM: 605708

KEGG: hsa:9826

STRING: 9606.ENSP00000357177

UniGene: Hs.516954