ARMCX1 Antibody

Code CSB-PA208029
Size US$297
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  • Western blot analysis of extracts from rat brain cells, using ARMX1 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ARMCX1 Polyclonal antibody
Uniprot No.
Target Names
ARMCX1
Alternative Names
ARMCX 1 antibody; AD032 antibody; ALEX1 antibody; ARM protein lost in epithelial cancers on chromosome X 1 antibody; Arm protein lost in epithelial cancers X chromosome 1 antibody; Armadillo repeat containing X linked 1 antibody; Armadillo repeat containing X linked protein 1 antibody; Armadillo repeat-containing X-linked protein 1 antibody; ARMCX1 antibody; ARMX1_HUMAN antibody; Protein ALEX1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human ARMX1.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1.
Gene References into Functions
  1. It is suggested that the ALEX1 protein is associated with tumorigenesis in cervical cancer and we speculate that the ALEX1 may plays a role as an oncogene in cervical cancer. PMID: 26464700
  2. ALEX1 is a crucial tumor suppressor gene involved in cell proliferation and apoptosis in breast cancer. PMID: 25921134
  3. Findings suggest that overexpression of ALEX1 (armadillo repeat containing, X-linked [ARMCX]) plays a negative role in colorectal tumorigenesis. PMID: 22494058
  4. Human Arm protein lost in epithelial cancers, on chromosome X 1 (ALEX1) gene is transcriptionally regulated by CREB and Wnt/beta-catenin signaling. PMID: 20398052
Subcellular Location
Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein.
Protein Families
Eutherian X-chromosome-specific Armcx family
Tissue Specificity
Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not or reduced expressed in lung, prostate, colon, pancreas and ovarian carci
Database Links

HGNC: 18073

OMIM: 300362

KEGG: hsa:51309

STRING: 9606.ENSP00000361917

UniGene: Hs.9728

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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