ASIC3 Antibody

1. The present review discusses the dual nature of ASIC3 in joint inflammation with possible mechanisms. PMID: 30035658
2. Acidic pH resulted in an increase in ASIC-3 expressionin the discs of paitents with intervertebral disc degeneration. PMID: 27853274
3. the data demonstrate a functional link between ASICs and [Ca(2+)]i/RhoA pathway, which contributes to the acidity-induced epithelial-mesenchymal transition. PMID: 28518134
4. Respiratory syncytial virus and measles virus infection upregulates ASICS3 expression in bronchial epithelial cells. PMID: 28187208
5. The results show that acid-sensing ion channel 1, acid-sensing ion channel 2, and acid-sensing ion channel 3 are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel-like currents were elicited by extracellular acid stimuli. PMID: 28618956
6. Blocking ASIC3 in interneurons from temporal lobe epilepsy patients decreased the frequency of action potential firing. PMID: 25476599
7. These findings open new perspectives on the roles of ASIC3 in the absence of tissue pH variation, as well as on the contribution of those channels to lipid-mediated signaling. PMID: 26772186
8. This study suggests that ASIC23may play a role as mediators of inflammatory pain and be involved in the pathogenesis of frozen shoulder. PMID: 26033064
9. Sea anemone peptide with uncommon beta-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3) and reveals analgesic activity. PMID: 23801332
10. Experiments with Asic3 inhibitors show that Asic3 inhibition leads to loss of pressure-induced vasodilation due to pressure detection failure rather than endothelial mechanisms. PMID: 22842475
11. The highly proton sensitive ASIC3 channels are predominantly distributed in peripheral sensory neurons, correlating with their roles in multimodal sensory perception, including nociception, mechanosensation, and chemosensation. PMID: 22778854
12. CAR and ASIC3 co-immunoprecipitate only when co-expressed with PSD-95. PMID: 22809504
13. Lignan from thyme possesses inhibitory effect on ASIC3 channel current. PMID: 22854960
14. ASIC3 is able to sense the extracellular pH in both directions and to dynamically adapt its activity between pH 5.0 and 8.0, playing a role in fine tuning neuronal membrane potentials and neuron sensitization in various pH environments. PMID: 22829666
15. The results showed that there was a significant increase in the mean relative optical density of ASIC2 and ASIC3 but not ASIC1a in the lining epithelium and glandular tubes of gastric mucosa in patients with Henoch-Schonlein purpura. PMID: 22157923
16. Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels. PMID: 21586569
17. The biological features of ASIC3 is discussed and recent advances on the role of ASIC3 in the pathogenesis and treatment of arthritis pain, are summarized. PMID: 19885742
18. Used coincidentally by sensory neurons to detect lactic acidosis, ASIC3 (amiloride-sensitive cation channel 3) interacts with adenosine triphosphate (ATP) to detect muscle ischemia. PMID: 21092862
19. Neither ASIC3 or ASIC1 knockout influences the development or maintenance of experimental neuropathic pain after nerve injury. PMID: 20693874
20. an independent association between an ASIC3 genetic polymorphism and insulin resistance in Taiwanese PMID: 20416288
21. role in modulating high-intensity pain stimuli PMID: 12060708
22. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current PMID: 15317815
23. Diclofenac studies show ASIC3 is a significant contributor to cutaneous acid-induced pain. PMID: 15574747
24. the interaction of ASIC3 and CFTR may contribute to defective salt and fluid transepithelial transport in the cystic fibrotic pulmonary system PMID: 17012229
25. These results suggest that the ASIC3 may be involved in blood pressure regulation. PMID: 18854755

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HGNC: 101

OMIM: 611741

KEGG: hsa:9311

STRING: 9606.ENSP00000297512

UniGene: Hs.647113