ASPRV1 Antibody

Code CSB-PA002231GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
ASPRV1
Alternative Names
ASPRV1; SASP; Retroviral-like aspartic protease 1; Skin-specific retroviral-like aspartic protease; SASPase; Skin aspartic protease; TPA-inducible aspartic proteinase-like protein; TAPS
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human ASPRV1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization.
Gene References into Functions
  1. results failed to find an association between ASPRV1 gene mutations and atopic eczema or clinically dry skin in the European populations studied PMID: 22318384
  2. SASPase activity is indispensable for processing profilaggrin and maintaining the texture and hydration of the stratum corneum. PMID: 21542132
  3. Identification and characterization of a new member of the aspartic proteases family, a unique epidermal retroviral-like protease, Skin ASpartic Protease. PMID: 16098038
  4. Taps expression is negatively associated with dedifferentiation and malignant progression in squamous cell carcinomas of the skin. PMID: 16565508
Subcellular Location
Membrane; Single-pass membrane protein.
Tissue Specificity
Expressed primarily in the granular layer of the epidermis and inner root sheath of hair follicles. In psoriatic skin, expressed throughout the stratum corneum. In ulcerated skin, expressed in the stratum granulosum of intact epidermis but almost absent f
Database Links

HGNC: 26321

OMIM: 611765

KEGG: hsa:151516

STRING: 9606.ENSP00000315383

UniGene: Hs.516253

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