Acetyl-Histone H4 (Lys5) Antibody

Datasheet
Code CSB-PA833785
Product Type Polyclonal Antibody
Size US$360
Uniprot No. P62805
Image
  • Western blot analysis of extracts from COS-7 cells untreated or treated with TSA, using Histone H4 (Acetyl-Lys5) Antibody.
Immunogen Peptide sequence around acetylation site of Lysine 5(S-G-R(p)-G-K) derived from Human Histone H4.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat,Monkey
Specificity The antibody detects endogenous level of Histone H4 only when acetylated at Lysine 5.
Tested Applications ELISA,WB;WB:1:500-1:1000
Relevance

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic acetylpeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific acetylpeptide. Non-acetyl specific antibodies were removed by chromatogramphy using
Clonality Polyclonal
Alias H4, H4/n, H4F2, H4FN, FO108
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names HIST1H4A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Involvement in disease Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.
Subcellular Location Nucleus, Chromosome
Protein Families Histone H4 family
Database Links

HGNC: 4781

OMIM: 142750

KEGG: hsa:121504

STRING: 9606.ENSP00000367034

UniGene: Hs.143080

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