Aldh1a1 Antibody

Code CSB-PA001565LA01MO
Size US$166
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  • Western blot
    All lanes: Aldh1a1 antibody at 8µg/ml + Mouse eye tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 55 kDa
    Observed band size: 55 kDa
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Aldh1a1 Polyclonal antibody
Uniprot No.
Target Names
Aldh1a1
Alternative Names
Aldh1a1 antibody; Ahd-2 antibody; Ahd2 antibody; Aldh1Retinal dehydrogenase 1 antibody; RALDH 1 antibody; RalDH1 antibody; EC 1.2.1.- antibody; EC 1.2.1.36 antibody; ALDH-E1 antibody; ALHDII antibody; Aldehyde dehydrogenase family 1 member A1 antibody; Aldehyde dehydrogenase antibody; cytosolic antibody
Raised in
Rabbit
Species Reactivity
Mouse
Immunogen
Recombinant Mouse Retinal dehydrogenase 1 protein (2-501AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated

The Aldh1a1 Antibody (Product code: CSB-PA001565LA01MO) is Non-conjugated. For Aldh1a1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA001565LB01MO Aldh1a1 Antibody, HRP conjugated ELISA
FITC CSB-PA001565LC01MO Aldh1a1 Antibody, FITC conjugated
Biotin CSB-PA001565LD01MO Aldh1a1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews
Average Rating:
5.0 - 1 reviews

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Applications : Western Blot

Sample type: Muscle Myo-lineage cells

Review: In order to verify the reliability of proteomics data, 7 DEPs were randomly selected for Western blot analysis. As shownin FigureS1, there lativea bundance sof selected proteins between Myo-L and Myo-Y determined by Western blot were highly consistent with the data of TMT analysis.

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Target Background

Function
Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (Probable). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins. Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission.
Gene References into Functions
  1. Data indicate involvement of non-POU domain-containing octamer-binding protein (NONO)/paraspeckle protein component 1 (PSPC1)-aldehyde dehydrogenase 1 (NONO/PSPC1-ALDH1A1) in the modulation of Sertoli cells (SCs) response to mono-(2-ethylhexyl) phthalate (MEHP) challenge. PMID: 28117896
  2. In ovaries lacking ALDH1A1, the onset of germ cell meiosis is delayed. PMID: 26892828
  3. Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis PMID: 26242870
  4. these experiments reveal an evolutionarily conserved GABA synthesis pathway mediated by aldehyde dehydrogenase 1a1 (ALDH1a1). PMID: 26430123
  5. Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A. PMID: 24466150
  6. Dkk-1 enhances resistance of osteosarcoma cells to stress by tipping balance of Wnt signaling in favor of the non-canonical Jun-mediated Wnt pathways. In turn, this results in transcriptional activation of ALDH1 through Jun-responsive promoter elements. PMID: 24577091
  7. Deletion of Aldh1a1 exacerbated alpha-synuclein-mediated DA neurodegeneration and alpha-synuclein aggregation, whereas Aldh1a1-null and control DA neurons were comparably susceptible to 1-methyl-4-phenylpyridinium-, glutamate-, or camptothecin-induced cell death. PMID: 24865427
  8. Our findings indicated that increased expression of ALDH1A1 in nasopharyngeal carcinoma was associated with enhanced invasiveness in the nude mouse. PMID: 23625387
  9. PSMB8, ALDH1A1, and HSPA4 were identified to be located in ovarian tissues, to regulate 12 cellular pathways, and demonstrate age-dependent dynamic changes in expression profiling. PMID: 24156634
  10. beta-escin inhibits tobacco carcinogen-induced lung tumor formation by modulating ALDH1A1-positive cells and RhoA/Rock signaling PMID: 23963803
  11. ALDH1A1 deficiency induces BMP2 and increases bone mass in vivo. PMID: 23951127
  12. retinoic acid-producing enzyme aldehyde dehydrogenase 1a1 (Aldh1a1) is an oncogene suppressor in specific B cell populations. PMID: 24080087
  13. Expression of ALDH1A1 isozyme transcripts was highest in ALDH(very-br) cells, intermediate in ALDH(br) cells, and lowest in ALDH(dim) cells. PMID: 23484127
  14. high fat diet mediates visceral fat formation through a sex-specific autocrine Aldh1 switch. PMID: 22933113
  15. Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism PMID: 22555438
  16. analysis of neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases PMID: 22384032
  17. This result demonstrates the critical role of stress resistance in myogenic cell therapy as well as confirms the role of ALDH as a marker for rapid isolation of murine and human myogenic progenitors for cell therapy. PMID: 22195027
  18. data establish Aldh1a1 and its substrate Rald as previously unrecognized determinants of adipocyte plasticity and adaptive thermogenesis, which may have potential therapeutic implications PMID: 22561685
  19. ALDH1A1 deficiency increases ALDH3A1 expression. Mice deficient in both ALDH3A1 & ALDH1A1 have fewer HSCs, aberrant cell-cycle distribution, increased reactive oxygen species, p38 MAP kinase activity & sensitivity to DNA damage. PMID: 22198153
  20. expression can be detected in canals of Hering and bile duct epithelial cells and is increased on liver injury PMID: 21953779
  21. in young adult animals with deletion of the Aldh1a1 gene there is altered dopamine metabolism and dysfunction of the dopamine transporter and dopamine release mechanisms PMID: 21784415
  22. regulation of fat depots through the concerted action of Aldh1 enzymes establishes retinoic acid-dependent tandem regulation of transcription factors ZFP423 and PPARgamma in a depot-specific manner PMID: 21436255
  23. Aldh1a1 plays a major role in cellular defense against oxidative damage induced by reactive lipid aldehydes in mouse liver PMID: 21256123
  24. We observed a decrease in the average number of Aldh1a1-positive cells in tumours with a non-invasive vs. solid morphology and in the average number of Aldh1a1-positive mammary tumour cells in low vs. intermediate and low vs. high-nuclear grade tumours. PMID: 21059124
  25. Retinoic acid-dependent signaling within the intestine is indispensable for RALDH enzyme activity in the draining mesenteric lymph nodes. PMID: 21220692
  26. The addition of all trans retinoic acid blocked DEAB-mediated expansion of ST-HSCs in culture, suggesting that ALDH1a1 regulates HSC differentiation via augmentation of retinoid signaling. PMID: 20054864
  27. Three retinaldehyde dehydrogenases (RALDH1, RALDH2 and RALDH3), show differential expression patterns throughout later mouse organogenesis PMID: 11744377
  28. RA-generating activities in Raldh2-null mouse embryos could be ascribed to RALDH1 in eye, nasal, and inner ear epithelia. PMID: 12454286
  29. RA signaling may be necessary only during early stages of retina development and is catalyzed by multiple enzymes, including Raldh1 PMID: 12808103
  30. Raldh1 functions downstream of Adh1 in the oxidative metabolism of excess retinol PMID: 12851412
  31. Expression of aldehyde dehydrogenase 1A1 (ALDH1A1) mRNA was found to be higher in brains of DBA/2 mice. PMID: 17010133
  32. ALDH1A1 mRNA. 3-deoxyglucosone dehydrogenase activity was undetectable in tissues from ALDH1A1(-/-) mice. PMID: 17175089
  33. Cellular expression of Aldh1 in the GI tract was studied. PMID: 17257171
  34. corneal ALDH3A1 and lens ALDH1A1 protect the eye against cataract formation via nonenzymatic (light filtering) and enzymatic (detoxification) functions. PMID: 17567582
  35. Aldh1a1 is not a critical regulator of adult stem cell function PMID: 18971422
  36. the Aldh1a1 gene is strongly expressed in a male-specific manner in somatic cells of the developing testis, beginning shortly after Sry expression is first detectable PMID: 19618468

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Subcellular Location
Cytoplasm, cytosol. Cell projection, axon.
Protein Families
Aldehyde dehydrogenase family
Tissue Specificity
Expressed in retina. Expressed in lens and cornea (at protein level). Expressed by midbrain dopamine neurons.
Database Links
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